Abstract Views :187 |
PDF Views:0
Authors
Affiliations
1 IBSS College of Pharmacy, Nimbari Phata, Buldana Road, Malkapur, Dist- Buldana-443 101, IN
2 I.B.S.S. College of Pharmacy, Malkapur- 443 101 (M.S.), IN
3 Govt. College of Pharmacy, Amravati-444 603 (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 3 (2009), Pagination: 254-256
Abstract
The purpose of the present investigation was to develop the sustain release matrix tablet of Tinospora cordifolia using the various polymers like HPMC (Hydroxy-Propyl-methyl-cellulose), Ethyl cellulose (EC), of different viscosity grade. Ethanolic extract of Tinospora cordifolia was used for the formulation of sustain release matrix tablet and tablet formulations were developed by using wet granulation method. Different diluents like lactose, magnesium stearate and cab-o-sil were used for improving flowability and compressibility. Binder such as polyvinyl pyrrolidone was used for optimization of the formulations. Sodium starch glycolate was used as disintegrating agent. Pre and post formulation parameters were studied for all the batches. HPMC –KM4 shows better result for matrix tablet in terms of sustain drug release with comparison to different viscosity grade of HPMC and ethyl cellulose. The dissolution study of the Tinospora cordifolia tablets exhibited 99.54% release of total polyphenol.
Keywords
Ethanolic Extract of Tinospora Cordifolia, HPMC, Ethyl Cellulose, Matrix Tablet.
