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Venkata Ramana Reddy, K.
- Molecular Aspects of BBB
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Authors
Affiliations
1 Dept. of Pharmaceutics, Sree Dattha College of Pharmacy, R.R. Dt., Andhra Pradesh, IN
2 Dept. of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt. A.P, IN
1 Dept. of Pharmaceutics, Sree Dattha College of Pharmacy, R.R. Dt., Andhra Pradesh, IN
2 Dept. of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt. A.P, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 2 (2014), Pagination: 105-109Abstract
The function of the BBB is dynamically regulated by various cells present at the level of the BBB. This realization implies better understanding of the relationship of at the BBB to drug structure and physicochemical properties. The physical barrier naming BBB is characterized by tight junctions between endothelial cells, by the absence of fenestrations and low occurrence of pinocytic activity 1.Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. The main factors that limit the penetration of lipophilic membranes by any molecule are its molecular weight and its ability to form hydrogen bonds and so bind to circulating plasma proteins. Tight junctions regulate the intracellular passage of molecules according to their physico-chemical properties (e.g. lipophilicity, ionization and polarity), where inter cellular penetration is regulated by influx and efflux transporters, endocytosis and passive diffusion.Keywords
Pharmacokinetic and Pharmacodynamic Parameters Affecting BBB. Fundamental Principles.- Pharmaceutical Excipients- Their Mechanisms
Abstract Views :171 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam. Ranga Reddy, District Andhra Pradesh -506501, IN
2 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., A.P, IN
3 Department of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt., A.P, IN
4 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., Andhra Pradesh, IN
1 Department of Pharmaceutics, Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam. Ranga Reddy, District Andhra Pradesh -506501, IN
2 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., A.P, IN
3 Department of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt., A.P, IN
4 Department of Pharmaceutics, Sree Dattha College of Pharmacy, R.R., Dt., Andhra Pradesh, IN