Research Journal of Pharmaceutical Dosage Form and Technology

K. Raghubabu ¹, N. Mohan ², B. Kalyanaramu ³, C. Ramadas ⁴, M. Narayanarao ⁴

Affiliations
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, IN
2 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP, IN
3 Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002, AP, IN
4 Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, IN

Abstract

An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2- bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).

Keywords

Sodamide, Propionitrile, Anti-Inflammatory, Tiaprofenic Acid, NSAID.

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K. Raghubabu ¹, V. Jagannadha Rao ², B. Kalyana Ramu ³, G. Chandra Sekhar ³, Srinivasa Rao ⁴

Affiliations
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
2 Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP), IN
3 Department of Chemistry, Maharajah’s College (Aided& Autonomous), Vizianagaram-535002 (AP), IN
4 Department of Organic Chemistry& Analysis of Foods, Drugs & Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam- 530003 Andhra Pradesh, IN

Abstract

Two simple and sensitive visible spectrophotometric methods (M₁ and M₂) have been developed for the estimation of ropinirole hydrochloride (RPR) in bulk and pharmaceutical dosage forms. Method M₁ involves Internal salt formation of aconitic anhydride, dehydration product of citric acid [CIA] with acetic anhydride [Ac₂O] to form colored chromogen with an absorption maximum of 580 nm and the method M₂ is based on the formation of green colored coordination complex by the drug with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 625 nm. Beer's law obeyed in the concentration range of 8-24μg/ml for method M₁ and 16-48 μg/ml for method M₂. Commercially available tablets were analyzed and the results are statistically compared with those obtained by the reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the ropinirole hydrochloride in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.

Keywords

Assay, Acetic Anhydride, Citric Acid, Cobalt Thiocyanate, Beer’s Law, Tablets.

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K. Raghubabu ¹, V. Jagannadharao ², B. Kalyana Ramu ³

Affiliations
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
2 Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP), IN
3 Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP), IN

Abstract

Two simple and sensitive extractive visible spectrophotometric methods (A&B) for the assay of ropinirole hydrochloride in pure and dosage forms based on the formation of colored chloroform soluble ion-association associates under specified experimental conditions are described. Two dyes namely acidic dye Tropaeoline ooo (TPooo, method A), Azo carmine- G (ACG, method B) are utilized. The extracts of the ion-associates exhibit absorption maxima at 485nm and 550nm for methods A and B respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (5.0-25) μg/ml for method A, (10-50) μg/ml for method B respectively. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the ropinirole hydrochloride in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.

Keywords

Assay, ACG, Anti Parkinson’s Agent, Ion-Association Methods, Statistical Analysis, TPOOO, Tablets.

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