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Vidyasagar, G.
- Preparation and Characterization of Self Emulsifying Drug Delivery System (SEDDS)
Authors
1 C/O M. B. Sarode, Shanti Nagar, Plot no.6, Yawal road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 4 (2010), Pagination: 290-294Abstract
A mixture of oil and surfactant (especially non-ionic) forms clear and transparent isotropic solution known as self-emulsifying system (SES). Lovastatin is HMG-CoA enzyme inhibitor. This enzyme is needed by the body to make cholesterol. Lovastatin causes cholesterol to be lost from LDL, but also reduces the concentration of circulating LDL (low density lipoprotein) particles. Animals studies demonstrated that lovastatin crosses the blood-brain and placental barriers. Elderly patients or those with renal insufficiency may have higher plasma concentrations of lovastatin after administration and may require a lower dose. SEDDS is prepared and filled in hard gelatin capsules. In vitro dissolution indicates that the release of lovastatin from SEDDS varied according to the type and ratio of the oil and surfactants. It was concluded that there was an increase in both the solubility and dissolution rate of drug in SEDDS form as compared to marketed tablet.Keywords
SEDDS, Enzymes.
- Formulation and Evaluation of Antihypertensive Microparticulate Drug Delivery System
Authors
1 C/O M. B. Sarode, Shanti Nagar, Plot No.6, Yawal Road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
3 J.Z.M.D.S. College of Pharmacy, Mamurabad, IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 3 (2010), Pagination: 237-240Abstract
The phenomenon of absorption via a limited part of the GI tract has been termed the "narrow absorption window", once the dosage form passes the absorption window, the drug will be neither bioavailable nor effective. In extreme cases, drugs, e.g. methyldopa, Captopril, that are insufficiently absorbed due to narrow absorption cannot be delivered entirely, and are either given by a parentral route, or the development of such medication, which is otherwise safe and effective, is stopped altogether. Diltiazem HCL is a calcium channel blocker widely used for the treatment of angina pectoris, arrhythmias and hypertension. Its short biological half life and thus frequent administration (usually three to four times a day) makes it a potential candidate for CR: SR preparations. It has a short plasma half life of about 3 hours. Diltiazem HCL microspheres were prepared by chemical cross linking method. The microspheres were spherical, discrete and free-flowing. Encapsulation efficiency was found to be 95.62 %. Diltiazem HCL release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres.Keywords
Microencapsulation, Controlled Release, Chitosan.- Formulation and Evaluation of Ethyl Cellulose Coated Microspheres of Aceclofenac
Authors
1 C/O M. B. sarode, Shanti Nagar, Plot no.6, Yawal Road , Bhusawal (M.S.), IN
2 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 41-43Abstract
The pain is symptomatic of some form of dysfunction and resultant inflammatory processes in the body. More than 15% of the worldwide population suffers for instance from some form of osteoarthritis and this incidence is even higher in elderly. As the world population is grows older, this incidence will continue to rise. Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities and due to its preferential cox-2 blockade it has better safety than conventional NSAIDs with respect to adverse effects on gastrointestinal and cardiovascular system. Ethyl cellulose microspheres of Aceclofenac were prepared by emulsion- solvent evaporation technique that is an industrially feasible technique. The microspheres are spherical, discrete and free-flowing. Encapsulation efficiency was found to be 81%. Aceclofenac release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres. These microspheres were found suitable for oral controlled release.