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Bhowmik, Debjit
- Formulation and Evaluation of Methyl Phenidate Sustained Release Tablets
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Authors
Affiliations
1 Himachal Institute of Pharmaceutical Education & Research (HIPER), Nadaun, H.P., IN
2 Institute of Pharmacy, Vikarm University, Ujjain, Madhya Pradesh, IN
3 Advance Institute of Biotech and Paramedical Sciences, Kanpur, IN
4 KHBS College of Pharmacy, Jaunpur, Uttar Pradesh, IN
1 Himachal Institute of Pharmaceutical Education & Research (HIPER), Nadaun, H.P., IN
2 Institute of Pharmacy, Vikarm University, Ujjain, Madhya Pradesh, IN
3 Advance Institute of Biotech and Paramedical Sciences, Kanpur, IN
4 KHBS College of Pharmacy, Jaunpur, Uttar Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 199-206Abstract
Methyl phenidate is a medication that belongs to the drug class called central nervous system stimulants. Methylphenidate is prescribed for treating narcolepsy (uncontrollable sleepiness), and attention-deficit hyperactivity disorder (ADHD). The aim of the current investigation is to design oral twice a daily sustained release matrix tablets of methylphenidate 20mg, used for the treatment of narcolepsy and ADHD which can release the drug for 10 to 12 hours. The matrix tablets were prepared by the wet granulation method using varying concentrations of sustained release polymers HPMC, Eudragit and Ethyl cellulose. The compatibility of the drug with polymers and other excipients was ruled out by FT-IR studies and found to be compatible. The Methyl phenidate powder and the powder-blends of tablets were evaluated for their physical properties like angle of repose, bulk density and compressibility index and found to be good and satisfactory. The manufactured tablets were evaluated for in process and finished product quality control tests including appearance, dimensions, weight variation, hardness, friability, drug content uniformity, and in vitro drug release. The results of dissolution studies indicated all formulations released up to 12 hours and formulation containing ethyl cellulose (5%) i.e. F7 was the most successful formulation with 96.72% drug release at the end of 12 hours. Based on mathematical models the formulation F7 fitted into zero order and Korsmeyer-Peppas plot with 0.942 and 0.999 regression values respectively and show Fickian diffusion mechanism release.Keywords
Methyl Phenidate, Sustain Release Tablets, In-Vitro Dissolution Study.- Formulation and Evaluation of Telmisartan Fast Dissolving Tablets by Direct Compression Method
Abstract Views :170 |
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Authors
Affiliations
1 Himachal Institute of Pharmaceutical Education and Research, Nadaun, Hamirpur, H.P., IN
2 Department of Pharmacy, Coimbatore Government Medical College, Coimbatore, IN
1 Himachal Institute of Pharmaceutical Education and Research, Nadaun, Hamirpur, H.P., IN
2 Department of Pharmacy, Coimbatore Government Medical College, Coimbatore, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 3 (2017), Pagination: 131-139Abstract
Telmisartan is a ACE inhibitor anti-hypertensive drug. Hence, in the present work, Telmisartan fast dissolving tablets will be prepared by using different super disintegrating agents. The amount of drug that is subject to first pass metabolism is reduced as compared to mouth dissolving tablets. Orally disintegration tablets contain wide variety of pharmaceutical active ingredients covering many therapeutic categories. The time for disintegration of orally disintegrating tablets are generally considered less than one minute. Orally disintegrating tablets are characterized by high porosity, low density and low hardness. The blend was examined for the precompressional parameters and post-compression parameters. Drug compatibility with excipients was checked by FTIR studies. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. In all the formulations, friability is less than 1%, indicated that tablets had a good mechanical resistance. Drug content was found to be in the range of 98 to 102%, which is within acceptable limits. Hardness of the tablets was found to be in the range of 3-4 Kp. The in vitro dispersion time was found to be in the range of 38-112sec with rapid in vitro dissolution within 3 min. No chemical interaction between drug and excipients was confirmed by FTIR studies. The drug release from tablets of Telmisartan prepared by direct compression showed that 98.20% drug release within 15 minutes.Keywords
Telmisartan, Fast Dissolving Tablets, Super Disintegrants.References
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