Research Journal of Pharmaceutical Dosage Form and Technology

P. S. Vishwe ¹, S. T. Deshpande ¹, M. B. Shinde ¹, D. G. Baheti ¹

Affiliations
1 SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune- 412210, IN

Abstract

Comparison of the optimum conditions of alkaline-catalyzed transesterification process for biodiesel production from pure sunflower oil (PSCO) and waste sunflower oil (WSCO) through transesterification process using alkaline catalysts was studied. To obtain a high quality biodiesel fuel that comply the specification of standard methods, some important variables such as reactants and catalytic activities were selected. The highest approximately 99 % biodiesel yield acquired under optimum conditions of 5:1 volumetric oil-to-methanol ratio, 0.35% NaOH catalyst at 50°C reaction temperature. The research demonstrated that biodiesel obtained under optimum conditions WSCO was of good quality and could be used as a diesel fuel which considered as renewable energy and environmental recycling process from waste oil after frying.

Keywords

Biodiesel, Transesterification, Sunflower Cooking Oil, Waste Cooking Oil.

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Swapnil T. Deshpande ¹, P. S. Vishwe ², Rohit D. Shah ³, Swati S. Korabu ³, Bhakti R. Chorghe ³, D. G. Baheti ²

Affiliations
1 Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
2 SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
3 Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, IN

Abstract

Diabetes is chronic metabolic disorder, resulting from insulin deficiency, characterized by hyperglycaemia, altered metabolism of carbohydrate, protein and lipids and an increased risk of vascular complication. The disadvantage of antidiabetic drugs such as more frequent of administration, extensive first passes metabolism and variable bioavailability, makes it is an ideal candidate for transdermal drug delivery systems. This article is dedicated to the review of antihypertensive transdermal patches in the perspective of enhancing the bioavailability as well as in improving the patient compliance. The various antidiabetic drugs sulfonylurea's (SU), biguanides, meglitinide, thiazolidinediones (TZDs) Currently a number of antidiabetic transdermal patches are introduced in to the pharmaceutical market. Most of the reported methods in the literature employed solvent evaporation method or solvent casting method for the preparation of transdermal patches. Depending on the release required over a period of time, the concentrations of polymer, plasticizer and penetrant were varied.

Keywords

Antidiabetic Drugs, Diabetes, Transdermal Drug Delivery Systems, Transdermal Patches.

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Swapnil T. Deshpande ¹, P. S. Vishwe ², Rohit D. Shah ³, Swati S. Korabu ³, Bhakti R. Chorghe ³, D. G. Baheti ²

Affiliations
1 Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
2 SCSSS's Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
3 Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, IN

Abstract

Recent technological advancements have been made in controlled oral drug delivery systems by overcoming physiological difficulties, such as short gastric residence time and highly variable gastric emptying time. Several technical approaches are currently utilized in the prolongation of gastric residence time, including high density, swelling and expanding, polymeric mucoadhesive, ion-exchange, raft forming, magnetic and floating drug delivery systems, as well as other delayed gastric emptying devices. The purpose of this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and disadvantages. The review also aims to discuss various parameters affecting the behavior of floating and swelling multiparticulate in oral dosage form summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating and swellable systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

Keywords

Floating Drug Delivery System, Gastroretentive Drug Delivery System, Hydrodynamically Balanced System, Evaluation Parameterin Vivo, In Vitro.

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