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Kalyana Ramu, B.
- A Novel Visible Spectrophotometric Method Development for the Estimation of Oseltamivir Phosphate in Capsules Based on Ferric Hydroxamate Reaction
Authors
1 Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002 (AP), IN
2 Department of Organic Chemistry& Analysis of Foods Drugs & Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam- 530003 Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 2 (2013), Pagination: 70-74Abstract
A Simple, sensitive spectrophotometric method in visible region was developed for the estimation of osetamivir phosphate in bulk and solid dosage forms. The method is based on the ferric hydroxamate reaction purple red colored species is formed with hydroxylamine-ferric per chlorate reagent in non aqueous medium which exhibits maximum absorption at 514 nm. Beer's law obeyed in the concentration range of 20-60μg/ml. commercially available Natflu capsules were analyzed, and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results obtained by the proposed method were in good agreement with the labeled amounts and found satisfactory and reproducible. The method is applied successfully for the estimation of the Oseltamivir phosphate in the presence of other ingredients that are usually present in dosage forms. The method offers the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.Keywords
Anti Viral, Capsules, Hydroxylamine, Ferric per Chlorate, Regression Equation.- Validated Visible Spectrophotometric Methods Development for the Assay of Ropinirole Hydrochloride in Pharmaceutical Preparations
Authors
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
2 Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP), IN
3 Department of Chemistry, Maharajah’s College (Aided& Autonomous), Vizianagaram-535002 (AP), IN
4 Department of Organic Chemistry& Analysis of Foods, Drugs & Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam- 530003 Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 5 (2012), Pagination: 267-271Abstract
Two simple and sensitive visible spectrophotometric methods (M1 and M2) have been developed for the estimation of ropinirole hydrochloride (RPR) in bulk and pharmaceutical dosage forms. Method M1 involves Internal salt formation of aconitic anhydride, dehydration product of citric acid [CIA] with acetic anhydride [Ac2O] to form colored chromogen with an absorption maximum of 580 nm and the method M2 is based on the formation of green colored coordination complex by the drug with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 625 nm. Beer's law obeyed in the concentration range of 8-24μg/ml for method M1 and 16-48 μg/ml for method M2. Commercially available tablets were analyzed and the results are statistically compared with those obtained by the reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the ropinirole hydrochloride in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.Keywords
Assay, Acetic Anhydride, Citric Acid, Cobalt Thiocyanate, Beer’s Law, Tablets.- Assay of Tolterodine Tartrate in Bulk and Capsule Formulations by using Simple and Affordable Visible Spectrophotometric Methods
Authors
1 Department of Organic Chemistry and Analysis of Foods Drugs and water Laboratories, AU College of Science and Technology, Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
2 Department of Organic Chemistry, AU College of Science and Technology, Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
3 Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 4 (2012), Pagination: 211-215Abstract
Two simple, sensitive and affordable visible spectrophotometric methods (M1 and M2) have been developed for the estimation of tolterodine tartrate (TT) in bulk and dosage forms. Method M1 involves Internal salt formation of aconitic anhydride, dehydration product of citric acid [CIA] with acetic anhydride [Ac2O] to form colored chromogen with an absorption maximum of 565 nm and the method M2 is based on the formation of green colored coordination complex by the drug with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 625 nm. Beer's law obeyed in the concentration range of 8-24μg/ml for method M1 and 16-48 μg/ml for method M2. Commercial available capsules were analyzed and the results are statistically compared with those obtained by the reference UV method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the tolterodine tartrate in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.
Keywords
Assay, Acetic Anhydride, Citric Acid, Cobalt Thiocyanate, Beer’s Law, Nitro Benzene, Capsules.- Development and Validation of Extractive Visible Spectrophotometric Methods for Determination of Ropinirole Hydrochloride in Pharmaceutical Dosage forms Based on Ion-Association Complex Formation
Authors
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
2 Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP), IN
3 Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 172-176Abstract
Two simple and sensitive extractive visible spectrophotometric methods (A&B) for the assay of ropinirole hydrochloride in pure and dosage forms based on the formation of colored chloroform soluble ion-association associates under specified experimental conditions are described. Two dyes namely acidic dye Tropaeoline ooo (TPooo, method A), Azo carmine- G (ACG, method B) are utilized. The extracts of the ion-associates exhibit absorption maxima at 485nm and 550nm for methods A and B respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (5.0-25) μg/ml for method A, (10-50) μg/ml for method B respectively. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the ropinirole hydrochloride in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.Keywords
Assay, ACG, Anti Parkinson’s Agent, Ion-Association Methods, Statistical Analysis, TPOOO, Tablets.- Sensitive Visible Spectrophotometric Methods Development for Estimation of Sapropterin Dihydrochloride in Tablet Dosage Form
Authors
1 Department of Organic Chemistry and Analysis of Foods Drugs and Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003, Andhra Pradesh, IN
2 Department of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002 (AP), IN