Research Journal of Pharmaceutical Dosage Form and Technology

S. M. Sarode ¹, G. Vidya Sagar ², M. K. Kale ³, P. K. Nimase ⁴, A. P. Kulkarni ³, S. D. Firke ³, B. M. Firke ³, P. D. Warke ³, M. A. Chaudhari ³

Affiliations
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN

Abstract

The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.

Keywords

Floating Alginate Beads, Emulsion Gelation, Clarithromycin, Controlled Release.

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M. D. Patil ¹, R. V. Keny ², R. B. Pimprikar ³, S. B. Yashwante ³, D. S. Saindane ³, S. K. Mandlik ², Mujawar Tabrej ³, M. K. Kale ⁴, B. M. Firke ⁴

Affiliations
1 255- Shramsafalya, Niwas, Janta Park, Navapur, Dist. Nandurbar, MS, PIN- 425418, IN
2 Government College of Pharmacy, Goa, IN
3 Gangamai College of Pharmacy, Nagaon, Dhule(M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S.), IN

Abstract

The effect of molecular weight of polyethylene glycols (PEGS) and drug/PEG ratio on the structure and dissolution rates of the solid dispersions with Telmisartan have been examined. Telmisartan (TEL) was chosen as a model drug due to its poor and pH dependent water solubility. The alkalizer used to modify the pH of TEL was NaOH, in the SD system significantly increased the drug dissolution rate in gastric fluid (pH 1.2) . Structural change in drug crystallinity to an amorphous form was also a contributing factor based on differential scanning calorimetry (DSC) thermograms and powder X-ray diffraction (PXRD) patterns. The drug frequency of the C=O band decreased and the O–H broad band in the Fourier transform infrared (FTIR) spectra disappeared when this alkalizer was added. It was evident that the alkalizer in PEG 6000 based SDs synergistically enhanced dissolution of TEL not only by modulating pH but also by changing drug crystallinity to an amorphous form via molecular interactions.

Keywords

Telmisartan (TEL), Solid Dispersion (SD), Alkalizer, Hot Melt Method.

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