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Sharma, Ashish Kumar
- Development and Evaluation of Transdermal Drug Delivery System of Ivabradine Hydrochlride
Authors
1 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
2 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 4 (2013), Pagination: 237-241Abstract
Transdermal patches are designed to slowly deliver the drug substance(s) through the intact skin; resulting in a prolonged and adequately constant systemic absorption rate after passing through the skin barriers, and it avoid first pass effect. Through a diffusion process, the drug enters the bloodstream directly though the skin. For this studies design the transdermal drug delivery system of Ivabradine hydrochloride with ERS100 and Hydroxy propyl methyl cellulose polymer in various concentrations. Propylene glycol was used as a plasticizer and dimethyl sulphoxides used as permeation enhancer. Characterization of transdermal patch is use to check it's quality, thickness, weight of patch, uniformity and in vitro permeation studies. The market for transdermal products has been in a significant upward trend that is likely to continue for the foreseeable future. It was observed that the formulation containing ERS100: HPMC K100M (4:6) showed ideal higuchi release kinetics. On the basis of in vitro drug release through skin permeation performance, Formulation A2 was found to be better than other formulations and it was selected as the optimized formulation. An increasing number of TDD products continue to deliver real therapeutic benefit to patients around the world.Keywords
Ivabradine Hydrochloride, HPMC, ERS100, Transdermal Patch, Permeation Studies.- Formulation and Evaluation of Transdermal Patches of Nebivolol Hydrochloride
Authors
1 Gyan Vihar School of Pharmacy, SGVU, Mahal Road, Jagatpura, Jaipur, IN
2 Lordshiva College of Pharmacy, Sirsa, Haryana, IN
3 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 5 (2012), Pagination: 272-277Abstract
Aim:- The present study is to formulate the matrix type transdermal patches of Nebivolol hydrochloride as a model drug with combination of HPMC K100M and ERS-100 to minimize the dose of the drug for lesser side effect.
Method:-Matrix type transdermal patches containing Nebivolol hydrochloride were prepared using two polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide was used as penetration enhancer. Major
Results:-The physicochemical parameters like weight variation, thickness, folding endurance, drug content, Percentage moisture absorption and Percentage moisture loss were evaluated. All prepared formulations indicated good physical stability and no skin irritation. In-vitro drug release and drug permeation studies of formulations were performed by using Franz diffusion cells. Formulation prepared with hydrophilic polymer containing permeation enhancer showed best in-vitro skin permeation through rat skin (Wistar albino rat) as compared to all other formulations.
Conclusions:- On the basis of in vitro drug release through skin permeation performance, Formulation F1 was found to be better than other formulations and it was selected as the optimized formulation.