Research Journal of Pharmaceutical Dosage Form and Technology

A. Choudhury ¹, S. K. Dash ², A. Roy ³, S. Bahadur ³, S. Saha ³, S. Das ³

Affiliations
1 GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, IN
2 Girijanada Chowdhury Institute of Pharmaceutical Science, Azara Hathakhowapara, NH-37, Guwahati 781017, Assam, IN
3 Department of Pharmaceutics, GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, IN

Abstract

The purpose of the study was to develop a floating control drug delivery system of ranitidine hydrochloride and investigate the effect of formulation variables on drug release profile and floating property. Ranitidine hydrochloride (RHCl) was used as a model drug because of its short biological half life and site of release at stomach. Tablets were formulated using different concentration hydroxypropyl methyl cellulose K4M, carbopol 934.where Sodium bicarbonate and Citric acid used as a gas generating agent. The floating behavior and in-vitro dissolution studies are carried out in a USP type II apparatus in 0.1 (N) HCL. It was observed that all the prepared formulation shows good floating capabilities up to 15 to 18 hours and slow steady release profile up to 12 hours. The dissolution profiles were subjected various kinetic release equations and found that drug release from different polymeric matrix follows diffusion controlled process. It has been also observed that combination of HPMC K4M and carbopol 934 shows better results as compared to their single use.

Keywords

Floating Controlled Delivery System, Ranitidine Hydrochloride, Hydroxypropyl Methylcellulose K4 M, Carbopol-934.

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S. Vaghasia ¹, V. Kanthiya ², Sujoy Das ², R. K. Sethi ³, A. Choudhury ⁴

Affiliations
1 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228(MP), IN
2 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228 (MP), IN
3 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone-451228 (MP), IN
4 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228 (MP), IN

Abstract

In this study, tablets were formulated by wet granulation technique taking Paracetamol as model drug. Three mucoadhesive polymers namely hydroxyl propyl methyl cellulose K4M, methyl cellulose and poly vinyl pyrolidone were used for preparation of coating solution (1%,2% and 3%) as well as for development of sustained release tablets. All the evaluation were carried out before and after coating like thickness and diameter, weight variation, friability, disintegration, swelling index, Mucoadhesive strength, drug content and in-vitro release study. All the physical evaluation parameters were increases after coating when compare with normal tablet. Normal tablets were showed 95% release within 30 min where coated tablets showed 98% release over a period of 6hr. in water and release was diffusion controlled confirmed by Higuchi’s plot. Thus, the present study concluded that, we can development of sustained release formulation can be possible by coating using the mucoadhesive polymers.

Keywords

Punch, Coating, Diffusion, Sustained

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