Research Journal of Pharmaceutical Dosage Form and Technology

D. R. Mundhada ¹, A. V. Chandewar ¹

Affiliations
1 P. Wadhwani College of Pharmacy, Yeotmal, IN

Abstract

In-Situ Gel Delivery System In situ gelation is a process of gel formation at the site of action after the formulation has been applied at the site. Insitu gel phenomenon based upon liquid solution of drug formulation and converted into semi-solid mucoadhesive key depot. It permits the drug must be delivered in a liquid form or solution form.

Keywords

In-Situ Gel, Mucoadhesive, Depot.

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D. R. Mundhada ¹, A. V. Chandewar ¹

Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, IN

Abstract

Surfactants are compounds that lower the surface tension (or interfacial tension) between two liquids or between a liquid and a solid. Cationic surfactants are basically soaps or detergents, in which the hydrophilic, or waterloving, end contains a positively-charged ion, or cation. Typical examples are trimethylalkylammonium chlorides, and the chlorides or bromides of benzalkonium and alkylpyridinium ions. All are examples of quats, so named because they all contain a quaternary ammonium ion.

Keywords

Surfactants, Surface Tension, Cationic Surfactants, Quaternary Ammonium Ion.

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B. Roge Ashish ¹, S. Sakhare Ram ¹, R. L. Bakal ¹, M. A. Channawar ¹, B. V. Bakde ¹, S. R. Gawande ¹, A. V. Chandewar ¹

Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, IN

Abstract

Transdermal drug delivery system is emerging system as compaired to oral and parentral.in TDDS, patch system was developed to control the release of drug. Conventional transdermal drug delivery system achieved advantages over the oral and parenteral. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes were been developed as novel transdermal drug delivery system. Firstly, it delivers the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it channel the active entity to the site of action. However, TDDS has limited market success due to the barrier properties of the Stratum Corneum and stability of formulation. ethosomes is better achievement in vesicular drug delivery system, helpful to achieve goal needed by NTDDS. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. This review focus on introduction, mechanism of penetration, method of preparation, methods of characterization and application in the field.

Keywords

TDDS, CTDDS, NTDDS, Stratum Corneum , Vesicular Drug Delivery System, Ethosomes.

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M. N. Dahake ¹, P. P. Wattamwar ², R. A. Bongirwar ², D. S. Mohale ², R. L. Bakal ², A. V. Chandewar ²

Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
2 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN

Abstract

Oral delivery of drug is the most preferable route of drug delivery due to ease of administration, patient compliance and flexibility in formulation etc. However, it is a well accepted fact that it is difficult to predict the real in vivo time of release with solid, oral controlled release dosage forms. Various attempts have been made to prolong the retention time of the dosage form in the stomach. One such approach is development of floating Microspheres involves preparation of a device that remains buoyant in the stomach contents due to its lower density than that of the gastric fluids.Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. Floating microspheres are specially gaining attention due to their wide applicability in the targeting of drugs to stomach.

Keywords

Oral Controlled Release Dosage Form, Retention Time, Floating Microsphere.

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S. R. Gawande ¹, A. V. Chandewar ¹

Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, MS, IN

Abstract

Oral solid dosage form are more popular than other dosage form but suffer from problems like taste, solubility, bioavailability; so patient compliance. To improve patient compliance, melt in mouth tablets have emerged as an alternative to conventional oral dosage form. The aim is to provide the tablet that quickly melts upon contact with saliva and also provides a good mouthfeel.

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S. R. Sapkal ¹, S. B. Jaiswal ¹, A. V. Chandewar ¹, S. B. Gaikwad ¹, A. M. Pathan ¹

Affiliations
1 Department of Pharmaceutics, P. Wadhwani College of Pharmacy, Yavatmal (Maharashtra) 445001, IN

Abstract

In the recent years, considerable attention has been focused in the development of controlled release drug delivery system. The pellets have since long been used as an important formulation tool. Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small , free flowing , spherical or semispherical units referred to as pellets. Pellets range in size typically, between 500- 1500 μm. When pellet containing the active ingredient are administered in vivo in the form of suspension capsule or disintegrating tablets, they offer significant therapeutic advantage over single unit dosage forms. An ideal controlled drug delivery system is the one which delivers the drug at a predetermined rate, locally, or systemically, for a specified period of time. Controlled release pellet formulation can be formulated by many techniques such as extrusion/spheronization, powder layering, solution/suspension layering etc.

Various applications of pellets in controlled drug delivery system formulation, recent developments, polymer and excipients used for formulation of controlled release drug delivery system are discussed in this review.

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