Research Journal of Pharmaceutical Dosage Form and Technology

B. Desale Kishor ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Niosomes are non-ionic surfactant formation of vesicles by hydrating mixture of cholesterol and other lipids with or without incorporation. They are vesicular system that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are biodegradable, biocompatible, nonimmunogenic and exhibit flexibility in their structural characterization. Niosomes are preferred over liposomes because the former exhibit high chemical stability and economy. Different novel approaches used for delivering these drugs include liposomes, microspheres, nanotechnology, microemulision antibody loaded drug delivery, implantable pumps and niosomes. Niosomes are widely studied as an alternative to liposomes. They improve the therapeutic performance of the drug molecules by delayed clearance from the circulation, protecting drug from biological environment and restricting effects to target cells. This review article focuses on the advantages, disadvantages, preparation methods, factors affecting, characterizations, invitro methods, drug release kinetics, and application of niosomes.

Keywords

Niosomes, Vesicles, Biological Environment, Composition.

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Gunjan L. Zope ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In recent years the novel technology of floating drug delivery system formulations are designed for the new drugs for oral targeted drug delivery. The drugs are delivered by conventional dosage forms are having very short residence time, but the drugs which are act in stomach are have more residence time. The floating drug delivery systems are of particular interest for drugs drugs that are locally active and narrow absorption window in stomach. System which are retained in the stomach for a longer period of time and there by improve the bioavailability of drugs. In this review the various advantages are given which are very important for controlled drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids. When the system floats on gastric contents the drug is released slowly at the desire rate from system. The polymers are suitable for floating drug delivery system are covered in this review.

Keywords

Floating Drug Delivery System, Mechanism and Types of FDDS, Evaluation of FDDS.

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S. Waghmare Sneha ¹, V. Kadam Trupti ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Systemic anti-infective agents are progressively utilized as a part of the treatment of periodontal contaminations. Whilst these medications are utilized basically on an experimental premise, a few doctors battle that discerning utilization of anti-infective ought to be the standard because of their wide ill-use and worldwide development of antiinfective safe living beings.

This is an audit of the standards and balanced anti-infective treatment, treatment objectives, drug conveyance courses and different anti-toxins utilized as a part of the administration of periodontal infections. The accessible information demonstrate, all in all, that mechanical periodontal treatment alone is satisfactory to enhance or determination the clinical condition as a rule, however adjunctive anti-infective agents, delivered systemically, can improve the impact of help in particular circumstances. This is especially valid for forceful periodontitis in patients with summed up systemic ailment that may influence host safety, and in the event of poor reaction to customary mechanical treatment. This article gives a redesign on systemic anti-infective treatment for the treatment of periodontitis.

Keywords

Anti-Infective Agents, Periodontitis, Metronidazole, Tetracycline, Clindamycin.

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V. Kadam Trupti ¹, S. Waghmare Sneha ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Acne vulgaris is a standout amongst the most widely recognized skin issue of pilosebaceous follicle described by papules, knobs, growths, comedones, pustules and regularly scars essentially scattered on the face, midsection and upper back. Pimple inflammation is a typical skin ailment that includes individual of all ages. Skin inflammation is delivered by the gram positive anaerobic microorganism (Propionibacterium acnes) and perceived as discharge framing microbes. Diverse parts of restorative plants and dermatological medications are utilized for the treatment of skin inflammation. In topical specialists; benzoyl peroxide, anti-infection agents, retinoids, and so on are the backbone of treatment; can be given in combination. While systemic treatment incorporates oral anti-microbials, hormonal therapy, and isotretinoin, contingent on the need of patients it must be chosen. Physical treatment in the type of injury evacuation, photograph help is likewise useful in few of them. Since different old and new topical and systemic specialists are accessible to treat acne vulgaris, it at some point confound treating dermatologist.

Keywords

Acne Vulgaris, Propionibacterium Acnes, Staphylococcus Epidermidis.

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