Research Journal of Pharmaceutical Dosage Form and Technology

Yamunappa ¹, Pooja Shetty ¹, Prathibha Suvarna ¹, V. B. Narayana Swamy ²

Affiliations
1 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Vamanjoor, Mangalore, IN

Abstract

In recent years, plant derived polymers have evoked tremendous interest due to their diverse pharmaceutical applications such as diluent, binder, disintegrate in tablets, thickeners in oral liquids, protective colloids in suspensions, gelling agents in gels and bases in suppository, they are also used in cosmetics, textiles, paints and paper-making. Basella alba is a wildly cultivated, cool season vegetable with climbing growth habit. Malabar spinach is high in vitamin A, vitamin C, iron and calcium. In the present work, an attempt was made to develop matrix tablets of diclofenac using natural release retardant isolated from Basella alba leaves and its efficiency was compared with most widely used natural release retardant like guar gum.

Diclofenac matrix tablets were formulated by using BAM in different concentrations (2.5%, 5%, 7.5%, 10% and 12.5%) by wet granulation method and its efficiency was compared with guar gum. The granules prepared were free flowing with good compressibility. Formulated tablets were evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, swelling studies and in vitro dissolution studies.

The hardness of the tablets was found to be 6-7 kg/cm2 and percentage friability of tablets was found to be less than 0.1% in all the cases and swelling index studies shown that as the conc. of polymer increased there was a proportional increase in the swelling index of tablet. Among the formulation studied, formulation F5 showed release of drug more than 12hrs and formulation F5 showed optimum release characteristics. The release was found to follow the anomalous non-Fickian diffusion. It revealed that as the conc. of polymer in tablet increased the release of the drug from the tablet decreased. It shown that BAM exhibited excellent retarding effect on drug release from the matrix tablets even at very low concentrations. Stability studies were carried out at 400C±20C/75%±5% RH for formulation F5 for 30 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, swelling index and in vitro drug release.

Keywords

Matrix Tablets, Diclofenac, Basella alba Mucilage, Release Retardant, Wet Granulation, Guar Gum.

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Yamunappa ¹, Ravi Kumar ¹, Pooja Shetty ¹, Prathibha Suvarna ¹, V. B. Narayana Swamy ²

Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN

Abstract

The objective of this research was to formulate fast dissolving tablets of Pravastatin sodium that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Pravastatin sodium is used for the treatment of myocardial infarction. Fast dissolving tablets of pravastatin sodium were prepared by direct compression method using three different superdisintegrants-Sodium starch glycollate, Crosscarmellose sodium and Crosspovidone (2%, 4% and 6%) and three different diluents (mannitol and spray dried lactose) in different concentrations. Eighteen formulations were prepared by using different diluents and evaluated were evaluated for various pre and post compression parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner's ratio, tablet hardness, friability, weight variation, wetting time, water absorption ratio in vitro dispersion time, drug content and in vitro dissolution studies. FTIR and DSC studies revealed that there was no chemical interaction between the drug and the excipients. Formulation L6 was found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. The formulation L6 containing spray dried lactose as diluent and crosspovidone (6%) was found to be the optimized combination. Stability studies were carried out at 25°C±20°C/60%±5% RH and 400°C±20°C/75%±5% RH for formulation L6 for 60 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time and in vitro drug release.

Keywords

Fast Dissolving Tablets, Pravastatin Sodium, Superdisintegrant, Direct Compression, Sodium Starch Glycollate, Crosscarmellose Sodium, Crosspovidone.

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