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Choudhury, S.
- Alterations in the Erythrocyte Membrane and Ultrastructural Changes in the Liver and Kidney of Albino Mice Exposed to Fipronil
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1 Microbial & Agricultural Ecology and Biodiversity Conservation Laboratory, Department of Ecology and Environmental Science, Assam University, Silchar-788011, IN
2 Department of Chemistry, Assam University, Silchar-788011, IN
1 Microbial & Agricultural Ecology and Biodiversity Conservation Laboratory, Department of Ecology and Environmental Science, Assam University, Silchar-788011, IN
2 Department of Chemistry, Assam University, Silchar-788011, IN
Source
Nature Environment and Pollution Technology, Vol 16, No 1 (2017), Pagination: 273-278Abstract
Fipronil is a highly active, broad spectrum systemic pesticide belonging to the phenyl pyrazole group of chemicals. The aim of the present study was to observe the alterations in the surface morphology of erythrocyte membranes of Swiss albino mice exposed to fipronil with the help of scanning electron microscope (SEM) and also its effect on the liver and kidney with the help of transmission electron microscope (TEM). The animals were divided into control group which received distilled water via intraperitoneal injection, and a treated group which received 1/3<sup?rd of LD50 dose of fipronil intraperitoneally, every 24 hours for 30 days. Various types of alterations in the morphology of the red blood cells of the fipronil treated mice were observed. There was decrease in discocytes and increase in the number of echinocytes, spherocytes and ovalocytes. In case of liver, the degeneration of the nucleus, nucleolus, nuclear membrane and mitochondria were commonly observed in all the treatments compared to the control. The cytoplasm was also found to be vacuolated with the breakdown of the organelles. The kidney cells of the treated mice were also observed with different degrees of degeneration. The mitochondria were damaged with destructed cristae surrounded by basal membrane that is disorganized and the nucleus was shrunken with dense chromatin condensation. Presence of vacuoles in the cytoplasm was seen as well as thickening of the glomerular basement membrane was observed.Keywords
Albino Mice, Electron Microscopy, Erythrocyte Membrane, Fipronil.References
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