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Macabeo, Allan Patrick G.
- Toxicological Analysis of Phthalates from Dust Samples Collected in Selected Philippine Light Rail Transit Stations
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Authors
Arnold V. Hallare
1,
Jan Luis Anton C. Chan
1,
Bea Maria Sarah P. Tan
1,
Peter Yuosef M. Rubio
2,
Else G. Dapat
3,
Allan Patrick G. Macabeo
2
Affiliations
1 Department of Biology, CAS, University of the Philippines Manila, Padre Faura St., 1000 Manila, PH
2 Laboratory for Organic Reactivity, Discovery and Synthesis, Research Center for Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., 1015 Manila, PH
3 Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, 1102, PH
1 Department of Biology, CAS, University of the Philippines Manila, Padre Faura St., 1000 Manila, PH
2 Laboratory for Organic Reactivity, Discovery and Synthesis, Research Center for Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., 1015 Manila, PH
3 Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, 1102, PH
Source
Nature Environment and Pollution Technology, Vol 16, No 1 (2017), Pagination: 11-19Abstract
Phthalates are the most common form of plasticizers. Due to the ease with which phthalates diffuse from their plastics and the sheer volume of plastics that have been introduced to the environment, they represent one of the most ubiquitous and persistent chemicals known. Phthalates are known to have several toxic effects. The study was carried out to identify the phthalates found in the urban dusts that have accumulated from underneath the LRT1 stations at Monumento, R. Papa, and EDSA in Metro Manila, and to determine their embryotoxic potential. The urban dust samples were subjected to solid phase extraction (SPE) and gas chromatography-mass spectrometry (GC-MS). Six phthalates were identified, and the extract was then used in the zebrafish embryo toxicity (ZFET) test. Lethal and sublethal end points were observed in the zebrafish embryos. Low dilutions were found to be highly embryo toxic and a dose-response relationship was seen in dilutions ranging from 1:4 to 1:40. The LC50 of the phthalate mixture was also obtained and found to be 9.188 μg/mL. This study elucidated some of the toxic effects of the phthalates, but further studies must be performed to evaluate the toxicity of the individual phthalates, some of whose effects are relatively unknown.
Keywords
Phthalates, Teratogenicity, Zebrafish, Embryotoxicity.Full Text
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