Ravindra Sonawane ¹, Suhas Patil ², Tushar Godbole ², Sanket Pande ², M. K. Tolani ²

Affiliations
1 Department of Pediatrics, Dr. Vasantrao Pawar Medical College Hospital and Research Center, Nashik, IN
2 Department of Paediatrics, Dr. Vasantrao Pawar Medical College and Research Centre, Nasik, IN

Abstract

Objective: To study the effect of Synbiotics on weight gain and feed tolerance of newborns.

Methods: This prospective interventional trial included 50 newborns treated with a dietary supplement containing Synbiotics in addition to the routine treatment and 48 newborns served as control without Synbiotics supplement. The primary outcome was weight gain and feed tolerance. Results: Newborns in the Synbiotics group reached the full feeds earlier as compared to those in Control group (7.5 ± 4.26 days Vs 14.02 ± 7.88 days p=0.532) along with better weight gain(14.61 ± 9.6 grams per day Vs 2.97 ± 3.81 grams per day p=0.0000001).

Conclusions: Newborns receiving Synbiotics are more likely to reach full feeds earlier and show better weight gain.

Keywords

Newborns, Probiotics, Prebiotics, Synbiotics, Feed Tolerance, Weight Gain

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Abhishek Janjale ¹, Sanket Pande ², Ravindra Sonawane ¹, Nilesh Ahire ¹, Sagar Sonawane ¹

Affiliations
1 Department of Paediatrics, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik - 422003, IN
2 Department of Paediatrics, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati - 444603, IN

Abstract

Introduction: The present study was to emphasize the chief causative factors, clinical manifestations, various hematological and morphological types in children with severe anemia, admitted to the pediatric wards of a tertiary care hospital. Objectives: The primary objective was to study clinical profile of severe anemia in children with various risk factor and hematological parameters among children with severe anemia. Methods: This was an observational study conducted in a tertiary health care institute. Children with severe anemia satisfying eligibility criteria with Hb less than or equal to 7gm/dl in age group 6 Month to 59 months. Less than or equal to 8gm/dl in age group 5 years to 14 years were included. Associated complaints and Clinical features were studied. Complete blood cell count with RBC indices- MCV, MCH and MCHC peripheral smear examination, reticulocyte count, stool examination, urine examination and Mantoux test were done in all patients. Serum ferritin, Hb electrophoresis, bone marrow examination, liver function test and renal function test, and x ray, U.S.G. abdomen, CT scan in relevant cases were done. Result: In this series 59 patients were included. Incidence of severe anemia was more in < 3.5 years age group (50.85%). Male to female ratio was 1.45:1. Out of 59 cases studied, 47(79.66%) had varying degrees of malnutrition. Pallor is the most prominent and characteristic sign noted in 59 cases (100%). Nutritional anemia was most common in 32 cases (55.93%) out of which 28 were microcytic and 4 were dimorphic. Associated infections were noted in 35 cases (59.32%). Conclusion: Nutritional deficiency is the most common cause of severe anemia especially iron deficiency anemia. Most of the children were malnourished and had infection indicating that severe anemia is directly related to malnutrition and infection. Pallor is the most consistent clinical sign of severe anemia. Severe anemia is more common in children aged < 3.5 years.

Keywords

Nutritional Deficiency Anemia, Pallor, Severe Anemia.

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