Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Chaudhari, Rajendra
- Study of Histopathological findings of Placenta in Cases of Deliveries at Tertiary Health Care Institute
Abstract Views :241 |
PDF Views:86
Authors
Affiliations
1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 4, No 2 (2017), Pagination: 165-171Abstract
Placentae from 67 mothers were studied, of which 28 were from mothers with uncomplicated pregnancies, and the remaining were associated with various maternal and fetal disorders. The purpose of this study was to describe the various gross and microscopic findings in the placentae, and to correlate them with various clinical and radiological abnormalities. Gross and microscopic examination of all the placentae was carried out. Formalin-fixed, paraffin-embedded tissue sections were used which were stained with hematoxylin and eosin. This study found a significant increase in neonatal weight, placental weight and placental diameter in cases of Gestational Diabetes Mellitus (GDM) as compared to cases of Normal Gestation (NG); while neonatal weight, placental weight and placental diameter were significantly lower in cases of maternal anemia, Pregnancy Induced Hypertension (PIH) and Intrauterine Growth Retardation (IUGR) as compared to cases of NG. This study found a significantly increased prevalence of calcifications, syncytial knots, infarcts and fibrinoid necrosis in cases of PIH as compared to cases of NG. Also, the prevalence of sclerotic villi, syncytial knots and chorangiosis was significantly more in cases of GDM than in cases of NG. In addition, the prevalence of sclerotic villi, syncytial knots, infarcts and fibrinoid necrosis was significantly more in cases of maternal anemia than in cases of NG. Overall, the study showed several significant findings, both gross and microscopic, in placentae from mothers and/or foetuses affected by various pathological processes. It was seen that conditions such as GDM, anemia, PIH etc. have a profound effect upon both the foetus and the placenta. Placental examination thus gives an idea of the type and severity of the condition complicating the pregnancy.Keywords
Anemia, Histopathology, Placenta, GDM, IUGR, PIH.Full Text
References
- Hagirtai B, Marton T, Cox BM. Examination of the human placenta. Journal of Clinical Pathology. 2004; 57:785–92.https://doi.org/10.1136/jcp.2003.014217 PMid:15280396 PMCid:PMC1770400
- Hay WW Jr, Catz CS, Grave GD, Yaffe SJ. Workshop summary: Fetal growth: Its regulation and disorders. Pediatrics.1999; 585–91.
- Pasca AM, Penn AA. The placenta: The lost neuroendocrine organ. Neo Reviews. 2010; 11:64–7. https://doi.org/10.1542/ neo.11-2-e64
- Dutta DC. Low birth weight. Text Book of Obstetrics. 6th ed. Calcutta: New Central Book Agency. 2004. p. 527.
- Dhabhai P, Ghanshyam G, Bapna N. Histological study of human placenta in normal and Pregnancy Induced Hypertension (PIH) cases. International Journal of Pharmaceutical Science Invention. 2013; 2(11):30–5.
- Treesh SA, Khair NS. Histological changes of the human placenta in pregnancies complicated with diabetes. J Cytol Histol.2015; 6:2. https://doi.org/10.4172/2157-7099.1000307
- Khaskhelli LB, Memon S, Goswami P, Bano S. Change in normal morphology of placenta and its possible effects on fetal outcome in diabetic mothers as compared to non-diabetic mothers. Jlumhs. 2013;12:1.
- Kotgirwar S, Ambiye M, Athavale S, Gupta V, Trivedi S.
- Study of gross and histological features of placenta in intrauterine growth retardation. J Anat Soc India. 2011; 60(1):37– 40. https://doi.org/10.1016/S0003-2778(11)80008-0
- Soni RB, Nair S. Study of histological changes in placenta of anaemic mothers. IOSR Journal of Dental and Medical Sciences. 2013; 9(6):42–6. https://doi.org/10.9790/08530934246
- Adil SAK, Rumana N. A study of histo pathological changes of placenta in severe anaemia. Journal of Evolution of Medical and Dental Sciences. 2012; 1(4):616–23. https://doi.org/10.14260/jemds/97
- Begum M, et al. Big placenta and anaemia in pregnancy.Journal of Shaheed Suhrawardy Medical College. 2009; 1(2):17–20.
- Lelic M, Bogdanovic G, Ramic S, Brkicevic E. Influence of maternal anemia during pregnancy on placenta and newborns. Medical Archives. 2014; 68(3):184–87. https:// doi.org/10.5455/medarh.2014.68.184-187 PMCid:PMC4240336
- Sankar KD, Bhanu PS, Ramalingam K, Kiran S, Ramakrishna BA. Histomorphological and morphometrical changes of placental terminal villi of normotensive and preeclamptic mothers. Anat Cell Biol. 2013; 46: 285–90. https://doi.org/10.5115/acb.2013.46.4.285 PMid:24386601 PMCid:PMC3875846
- Keche HA, Keche AS. Morphometric differentiation between placenta in PIH and normal pregnancy. Int J Med Sci Public Health. 2015; 4:250–5. https://doi.org/10.5455/ijmsph.2015.0711201457
- Elsennawy TMA. Effect of gestational diabetes on gross morphology, histology and histochemistry of human placenta.Endocrinol Metab Syndr. 2016; 5:227.
- Saini P, Jai P, Anjali J, Gyan C. Effect of gestational diabetes mellitus on gross morphology of placenta: A comparative study. Int J Anat Res. 2015; 3(1):889–94. https://doi.org/10.16965/ijar.2015.111
- Goswami PR, Shah SN. Placenta in normal and pregnancy induced hypertension in relation to its clinical significance: A gross study. International Journal of Scientific Study.2016; 4(7):58–61.
- Soni R, Sharma V, Nair S. Study of changes in placental morphology fate of fetus in anaemic mothers. Journal of Evolution of Medical and Dental Sciences. 2013; 2(31):5830–44.https://doi.org/10.14260/jemds/1067
- Sherin F, Afzal E, Seema N. Gross morphological changes in premature and postmature human plancentae. J Ayub Med Coll Abbottabad. 2015; 27(2):448–50. PMid:26411137
- Balihallimath RL, Shirol VS, Tyagi NK, Gan AM, Desai SP.Maternal determinants of placental morphometry and birth weight. International Journal of Medical Science and Public Health. 2014; 4(4):508–15. https://doi.org/10.5455/ijmsph.2015.1012201499
- Kambale T, Iqbal B, Ramraje S, Swaimul K, Salve S. Placental morphology and fetal implications in pregnancies complicated by pregnancy-induced hypertension. Med J DY Patil Univ. 2016; 9:341–7. https://doi.org/10.4103/09752870.182505
- Majumdar S. Study of placenta in normal and hypertensive pregnancies. J Anat Soc India. 2005; 54:34–8.
- Kurdukar MD, Deshpande NM, Shete SS, Zawar MP. Placenta in PIH. Indian J Pathol Microbiol. 2007; 50:493–7.PMid:17883116
- Ghomian N, Amouian S, Tavassoli F, Arbabzadeh T. Comparison of placental morphology and histopathology of intrauterine growth restriction and normal infants. Iranian Journal of Pathology. 2014; 9(1):9–16.
- Marconi AM, Paolinin CL, Zerbe G, Battaglia FC. Lactacidemia in Intrauterine Growth Restricted (IUGR) pregnancies: relationship to clinical severity, oxygenation and placental weight. Pediatric Research. 2006; 59:570–4. https://doi.org/10.1203/01.pdr.0000205477.70391.3e PMid:16549531
- Goswami P, Memon S, Pardeep K. Histological and radiological study of calcified placenta. IOSR Journal of Dental and Medical Sciences. 2013; 7(4):37–41. https://doi.org/10.9790/0853-0743741
- Verma R, Mishra S, Kaul JM. Cellular changes in the placenta in pregnancies complicated with diabetes. Int J Morphol.2010; 28(1):259–64.https://doi.org/10.4067/S071795022010000100038
- Edu A, et al. Placenta changes in pregnancy with gestational diabetes. Rom J Morphol Embryol. 2016; 57(2):507–12.PMid:27516026
- Huynh J, Dawson D, Roberts D, Bentley-Lewis R. A systematic review of placental pathology in maternal diabetes mellitus.Placenta. 2015; 36(2):101–14. https://doi.org/10.1016/j.placenta.2014.11.021 PMid:25524060 PMCid:PMC4339292
- Mardi K, Sharma J. Histopathological evaluation of placentas in IUGR pregnancies. Indian Journal Pathol Microbiol.2003; 46(4):551–4. PMid:15025340
- Bal K, Basu S, Bal R. Histology of placenta in intrauterine growth restricted pregnancy. Journal of Evolution of Medical and Dental Sciences. 2014; 3(64):14037–43. https://doi.org/10.14260/jemds/2014/3878
- Histopathological Evaluation of Carcinoma Breast with Significance of Histological Grading and Other Morphological Prognostic Factors at a Tertiary Health Care Institute
Abstract Views :165 |
PDF Views:112
Authors
Affiliations
1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 5, No 2 (2018), Pagination: 185-193Abstract
Background: Breast carcinoma is the second common malignancy among women. Pathological prognostic factors in breast cancer are now widely used to predict prognosis of breast carcinoma and to plan its effective management. Aim and Objectives: To analyze the spread and extent of various histological patterns of carcinoma breast, to do grading and staging of the tumors and to correlate above factors with the prognosis. Material and Methods: The present study was a prospective study of histopathological findings of modified radical mastectomy specimens received in the department of pathology of Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik over a period of 2 years and 3 months that is from June 2015 to September 2017. A total of 45 mastectomy specimens were analyzed in this period, using standard histopathology technique. Positive status of Axillary lymph nodes and other prognostic factors were analyzed. Nottingham Prognostic Index (NPI) was used to assess the prognosis. Follow up of all the patients was kept. Results: Out of 45 total cases, the most common histologic type was Invasive Ductal Carcinoma (NOS) (86.67%). The largest tumor size was 14.5cm. Maximum tumors were of Grade II. Out of the 45 cases, 31 (68.88%) cases showed tumor metastasis in axillary lymph nodes. 48.88% of the patients showed poor prognosis category with score greater than 5.4. Conclusion: After keeping follow up with the patients we came to a conclusion that, the lymph node status, tumor size, histologic pattern, histologic grade, necrosis and presence or absence of blood vessel invasion remains the best independent prognostic indicators.Keywords
Carcinoma Breast, Modified Bloom Richardson Score, Nottingham Prognostic Index, TNM Staging.Full Text
References
- Colditz G, Chia K.S. Invasive breast carcinoma: Introduction and general features. In: Pathology and Genetics. Tumors of the breast. 4th Ed. International Agency for Research on Cancer (IARC); 2012. p. 14−23.
- Rosai J. Breast. In: Rosai and Ackerman, editors. Surgical Pathology. 9th ed. Mosby; 2004. p. 1763−876.
- Hodi Z, Ellis IO, Elston CW, et al. Comparison of margin assessment by radial and shave sections in wide local excision specimens for invasive carcinoma of the breast, Histopathology. 2010; 56:573–80. https://doi.org/10.1111/j.1365-2559.2010.03518.x. PMid: 20459567.
- Blamey RW, Ellis IO, Pinder SE, Lee AH, Macmillan RD, Morgan DA et al. Survival of invasive breast cancer according to the Nottingham Prognostic Index in cases diagnosed in 1990–1999, Eur. J. Cancer. 2007; 43:1548–55. https://doi.org/10.1016/j.ejca.2007.01.016. PMid: 17321736.
- Carter CL, Allen C, Henson DE. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases, Cancer. 1989; 63:181−87. https://doi.org/10.1002/1097-0142(19890101)63:1<181::AID-CNCR2820630129> 3.0.CO;2-H.
- Ahmad Z, Khurshid A, Qureshi A, et al. Breast carcinoma grading, Estimation of tumor size, axillary lymph node status, staging, and Nottingham prognostic index scoring on mastectomy specimens, Indian J. Pathol. Microbiol. 2009; 52:477−81. https://doi.org/10.4103/0377-4929.56123. PMid: 19805950
- Reddy SR, Chaitanya B, P Swarna Latha et al. Histopathological prognostic factors in carcinoma breast An Indian institutional experience, International Journal of Medical Research and Review. 2014 Nov- Dec; 2(6).
- Pradhan A, Paudyal P, Sinha AK, Agrawal CS et al. Grading, staging and Nottingham prognostic index scoring of breast carcinoma, Journal of Pathology of Nepal. 2017; 7:1078–83. https://doi.org/10.3126/jpn.v7i1.16951.
- Ahmad Z, Khurshid A, Qureshi A. et al. Breast carcinoma grading, estimation of tumor size, axillary lymph node status, staging, and Nottingham prognostic index scoring on mastectomy specimens Department of Pathology and Microbiology, The Aga Khan University, Hospital, Karachi, Pakistan, Indian J. Pathol. Microbiol. 2009; 52(4):477−81. https://doi.org/10.4103/0377-4929.56123. PMid: 19805950.
- Saxena S, Rekhi B, Bansal A, Bagga A, Chintamani, Murthy NS. Clinico-morphological patterns of breast cancer including family history in a New Delhi hospital, India – A cross-sectional study, World J. Surg. Oncol. 2005; 3:67. https://doi.org/10.1186/1477-7819-3-67. PMid: 16236180, PMCid: PMC1277852.
- Gilchrist KW, Gray R, Fowble B, Torme DC, Taylor SG, Tumor necrosis is a prognostic predictor for early recurrence and death in lymph node-positive breast cancer. A 10 year follow-up study of 728 Eastern Cooperative Oncology Group Patients, J. Clin. Oncol. 1993; 11:1929−35. https://doi.org/10.1200/JCO.1993.11.10.1929. PMid:8410120.
- Rakha EA, Martin S, Lee AH, Morgan D, Pharoah PD, Hodi Z, Macmillan D, Ellis IO. The prognostic significance of lymphovascular invasion in invasive breast carcnimona, Cancer. 2012; 118:3670–80. https://www.ncbi.nlm.nih.gov/pubmed/22180017. DOI: 10.1002/cncr.26711
- Lee AK, DeLellis RA, Silverman ML, Heatley GJ, Wolfe HJ. Prognostic significance of peritumoral lymphatic and blood vessel invasion in node-negative carcinoma of the breast, J. Clin. Oncol. 1990; 8:1457–65. https://doi.org/10.1200/JCO.1990.8.9.1457. PMid: 2202788.
- Olivotto IA, Bajdik CD, Ravdin PM, et al. Population-based validation of the prognostic model ADJUVANT for early breast cancer, J. Clin. Oncol. 2005; 23(12):2716–25.