A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Shah, Maitri Amitkumar
- Comparative Efficacy of Three Low-Dose Isotretinoin Regimens in Treatment of Mild to Moderate Acne Vulgaris on the Face in Tertiary Care Institute
Authors
1 P.G. Resident, Department of Dermatology Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Nashik - 422003, Maharastra, IN
2 Professor and Head, Department of Dermatology Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Nashik - 422003, Maharastra, IN
Source
MVP Journal of Medical Sciences, Vol 6, No 2 (2019), Pagination: 133-138Abstract
Background: Acne is a disease that affects almost 100% of the population. The clinical presentation ranges from comedones, papules, pustules and nodules. Various systemic treatment modalities like oral antibiotics, retinoids, hormonal therapy and corticosteroids, are available with varied benefits and side effects. Aims: To study and compare the efficacy and safety profile of three low dose isotretinoin regimens in the treatment of mild to moderate acne vulgaris. Methods: 75 patients having mild to moderate acne vulgaris were randomized into three different low dose isotretinoin regimens. Each was consisting of 25 patients. Group A was prescribed 5 mg, Group B 10 mg and Group C 20 mg isotretinoin for 4 months. Clinical improvement and side effects were recorded. Results: All regimens showed clinical improvement in 4 months of therapy. Isotretinoin 20 mg was found to be superior in later half of therapy. But isotretinoin 10 mg and 20 mg both were statistically equally efficacious in mild to moderate acne vulgaris. Side effects were higher in Group C as compared to Group A and B. Conclusion: We conclude that all three low dose regimens were efficacious in mild to moderate acne vulgaris. Isotretinoin 10 mg was found to be an effective and safe treatment option in such cases.
Keywords
Acne, Isotretinoin, Low Dose.Full Text
References
- Tutakne MA, Chari KVR. Acne, rosacea and perioral dermatitis, IADVL Textbook of Dermatology, 3rd ed, 2008; 1(27):837−64.
- Agarwal US, Besarwal RK, Bhola K. Oral isotretinoin in different dose regimens for acne vulgaris: A randomized comparative trial, Indian J. Dermatol. Venereol. Leprol. 2011; 77:688−94. https://doi.org/10.4103/0378-6323.86482. PMid:22016276
- Amichai B, Shemer A, Grunwald MH. Low-dose isotretinoin in the treatment of acne vulgaris, J. Am. Acad. Dermatol. 2006 Apr; 54(4):644−46. https://doi.org/10.1016/j.jaad.2005.11.1061. PMid:16546586.
- Adityan B, Kumari R, Thappa DM. Scoring systems in acne vulgaris, Indian J. Dermatol. Venerol. Leprol. 2009; 75(3):323−26. https://doi.org/10.4103/0378-6323.51258. PMid:19439902.
- Titus S, Hodge Diagnosis and treatment of acne, Journal of American Family Physician. October 2012; 86(8):734−40.
- Layton A. The use of isotretinoin in acne, Dermato Endocrinology. 2009; 1(3):162−69. https://doi.org/10.4161/derm.1.3.9364. PMid:20436884.
- Hermes B, Praetel C, Henz BM. Medium dose isotretinoin for the treatment of acne, J. Eur. Acad. Dermatol. Venereol. 1998; 11:117−21. https://doi.org/10.1111/j.1468-3083.1998.tb00763.x.
- Mandekou-Lefaki I, Delli F, Teknetzis A, Euthimiadou R, Karakatsanis G. Low-dose schema of isotretinoin in acne vulgaris, Int. J. Clin. Pharmacol. Res. 2003; 23:41−46.
- Akman A, Durusoy C, Senturk M, Koc CK, Soyturk D, Alpsoy E. Treatment of acne with intermittent and conventional isotretinoin: A randomized, controlled multicenter study, Arch. Dermatol. Res. 2007; 299:467−73. https://doi.org/10.1007/ s00403-007-0777-2. PMid:17710426, PMCid:PMC2094720.
- Sardana K, Garg VK, Sehgal VN, Mahajan S, Bhushan P. Efficacy of fixed low-dose isotretinoin (20 mg, alternate days) with topical clindamycin gel in moderately severe acne vulgaris, J. Eur. Acad. Dermatol. Venereol. 2009; 23:556−60. https://doi.org/10.1111/j.1468-3083.2008.03022.x. PMid:19143903.
- De D, Kanwar AJ. Combination of low-dose isotretinoin and pulsed oral azithromycin in the management of moderate to severe acne: A preliminary open-label, prospective, non-comparative, single-centre study, Clin. Drug. Investig. 2011; 31:599−604. https://doi.org/10.2165/11539570000000000-00000. PMid:21591819.
- El-Sherif NA, Greiw AS, Benamer AM. Daily low dose versus intermittent isotretinoin regimens, Ibnosina. J. Med. BS. 2013; 5:296−302. https://doi.org/10.4103/1947489X.210559.
- Rao PK, Bhat RM, Nandakishore B, DandakeriS,Martis J, Kamath GH. Safety and efficacy of low dose isotretinoin in the treatment of moderate to severe acne vulgaris, Indian J. Dermatol. 2014; 59:316. https://doi.org/10.4103/0019-5154.131455. PMid:24891681, PMCid:PMC4037971.
- Rademaker M, Wishart J, Birchall N. Isotretinoin 5 mg daily for low -grade adult acne vulgaris - A placebo-controlled, randomized double-blind study, J. Eur. Acad. Dermatol. Venereol. 2014 Jun; 28(6):747−54. https://doi.org/10.1111/jdv.12170. PMid:23617693.
- Yap FB. Safety and efficacy of fixed-dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia, J. Cosmet. Dermatol. 2016; 0:1−5. https://doi.org/10.1111/jocd.12268. PMid: 27539948.
- Rasi A, Behrangi E, Rohaninasab M, Nahad ZM. Efficacy of fixed daily 20 mg of isotretinoin in moderate to severe scar prone acne, Adv. Biomed. Res. 2014; 3:103. https://doi.org/10.4103/2277-9175.129693. PMid:24804178, PMCid:PMC4009746.