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Retinopathy of Prematurity Screening in a Tertiary Care Centre


Affiliations
1 PG Resident, Department of Ophthalmology, Dr. Vasantrao Pawar Medical College and Hospital, Research Centre, Nasik – 422003, Maharashtra, India
2 Associate Professor, Department of Ophthalmology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, India
3 Professor and HOD, Department of Ophthalmology, Dr. Vasantrao Pawar Medical College and Hospital, Research Centre, Nashik – 422003, Maharashtra, India
 

Background: To conduct an effective ROP screening program according to the Indian standard needs and to identify the infants who could benefit from treatment and make appropriate recommendations on the timing of future screening. Aims and Objectives: To estimate the incidence of ROP among Premature infants. Materials and Methods: A Prospective Observational study of 2 years in which 170 patients were screened with following criteria: GA at birth of ≤35 weeks, BW <1700 gms, exposed to oxygen >30days, other factors that can increase the risk of ROP and where screening should be considered are premature babies >37 weeks and >1700gms but with the first screening was done within 4 weeks (30 days) of life in infants with age >28 weeks of GA, 2-3 weeks after birth if GA <28 weeks or BW is <1200gms. Results: Out of the 170 babies screened 35 babies had ROP. Incidence of ROP in our study was 20.59%. The sensitivity of AAP and UKRCPCH guidelines to ours were 77.14% and 60% respectively. Conclusion: ROP may be seen in heavier and larger babies in India that have consequently a shorter window period for development of ROP, Hence, a criteria screening even larger babies should be taken into consideration.


Keywords

Birth Weight, Gestational Age, Retinopathy of Prematurity, Screening.
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  • Terry TL. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens. I. Preliminary report. Am J Ophthalmol. 1942; 25:203–4 https://doi.org/10.1016/S0002-9394(42)92088-9
  • Heath P. Pathology of retinopathy of prematurity, RLF. Am J Ophthalmol. 1951; 34:1249–68. https://doi.org/10.1016/0002-9394(51)91859-4
  • Pejawar R, Vinekar A, Bilagi A. National neonatology foundation’s evidence-based clinical practise guidelines. Retinopathy of Prematurity, NNF India, New Delhi; 2010. p. 253–62.
  • Howson CP, Kinney MV, Lawn JE. March of dimes, PMNCH, save the children, WHO. Born too soon: The global action report on preterm birth. Geneva: World Health Organization; 2012.
  • Jalali S, Anand R, Kumar H, Dogra MR, Azad R, Gopal L. Programme planning and screening strategy in retinopathy of prematurity. Indian J Ophthalmol. 2003; 51(1):89–99.
  • Palmer EA, Flynn JT, Hardy RJ, et al., The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Incidence and early course of retinopathy of prematurity. Ophthalmology. 1991; 98(11):1628–40. PMID:1800923
  • American Academy of Pediatrics. Section on ophthalmology. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2005; 117:572–6. https://doi.org/10.1542/peds.2005-2749. PMid:16452383
  • LIGHT-ROP Cooperative Group. The design of the multicenter study of light reduction in retinopathy of prematurity (LIGHT-ROP). J Pediatr Ophthalmol Strabismus. 1999; 36(5):257–63. PMID:10505830
  • Hutchinson AK, Saunders RA, O’Neil JW, Lovering A, Wilson ME. Timing of initial screening examinations for retinopathy of prematurity. Arch Ophthalmol. 1998; 116(5):608–12. https://doi.org/10.1001/archopht.116.5.608. PMid:9596496
  • Fierson WM, Palmer EA, Biglan AW, Flynn JT, Petersen RA, Phelps DL. Screening examination of premature infants for retinopathy of prematurity. A Joint Statement of the American Academy of Pediatrics the American Association for Pediatric Ophthalmology and Strabismus the American Academy of Ophthalmology, American Academy of Pediatrics Section on Ophthalmology, Retinopathy of Prematurity Subcommittee, 1990 to 1996, Pediatrics. 1997 Aug; 100(2):273–4. https://doi.org/10.1542/peds.100.2.273
  • Murthy KR, Murthy PR, Shah DA, Nandan MR, Niranjan HS, Benakappa N. Comparison of profile of retinopathy of prematurity in semi urban/rural and urban NICUs in Karnataka, India. Br J Ophthalmol. 2013; 97:687– 9. Back to cited text no. 5. https://doi.org/10.1136/bjophthalmol-2012-302801. PMid:23603485
  • Hungi B, Vinekar A, Datti N, Kariyappa P, Braganza S, Chinnaiah S, et al. Retinopathy of prematurity in a rural Neonatal Intensive Care Unit in South India - A prospective study. Indian J Pediatr. 2012; 79:911–5. https://doi.org/10.1007/s12098-012-0707-y. PMid:22359197
  • Sundar KC, Meenakshi KD, Patil AB. A retrospective study on the risk factors for retinopathy of prematurity in NICU of tertiary care hospital. Int J Contemp Pediatr. 2018; 5:1447– 51. https://doi.org/10.18203/2349-3291.ijcp20182544
  • Ahuja AA, V Reddy YC, Adenuga OO, Kewlani D, Ravindran M, Ramakrishnan R. Risk factors for retinopathy of prematurity in a district in South India: A prospective cohort study. Oman J Ophthalmol. 2018; 11(1):33–7.
  • Alajbegovic-Halimic J, Zvizdic D, Alimanovic-Halilovic E, Dodik I, Duvnjak S. Risk factors for retinopathy of prematurity in premature born children. Med Arch. 2015; 69(6): 409–13. https://doi.org/10.5455/medarh.2015.69.409-413. PMid:26843736 PMCid:PMC4720470
  • Parekh A, Behera M, Kulkarni S, Narwadkar P, Natu S. Retinopathy of prematurity: A study of incidence and risk factors. Int J Contemp Pediatr. 2016; 3:1320–5. https://doi.org/10.18203/2349-3291.ijcp20163669
  • Higgins RD, Mendelsohn AL, DeFeo MJ, Ucsel R, Hendricks-Munoz KD. Antenatal dexamethasone and decreased severity of retinopathy of prematurity. Arch Ophthalmol. 1998; 116:601–5. https://doi.org/10.1001/ archopht.116.5.601. PMid:9596495
  • Rekha S, Battu RR. Retinopathy of prematurity: Incidence and risk factors. Indian Pediatr. 1996; 33:999–1003.
  • Gupta VP, Dhaliwal U, Sharma R, Gupta P, Rohtagi J. Retinopathy of prematurity - risk factors. Indian J Pediatr. 2004; 71:887–92. https://doi.org/10.1007/BF02830827. PMid:15531829
  • Parekh A, Behera M, Kulkarni S, Narwadkar P, Natu S. Retinopathy of prematurity: A study of incidence and risk factors. Int J Contemp Pediatr. 2016; 3:1320–5. https://doi.org/10.18203/2349-3291.ijcp20163669
  • Charan R, Dogra MR, Gupta A, Narang A. The incidence of retinopathy of prematurity in a neonatal care unit. Indian J Ophthalmol. 1995; 43:123–6.
  • Le C, Basani LB, Zurakowski D, Ayyala RS, Agraharam SG. Retinopathy of prematurity: Incidence, prevalence, risk factors, and outcomes at a tertiary care center in Telangana. J Clin Ophthalmol Res. 2016; 4:119–22. https://doi.org/10.4103/2320-3897.190785
  • Alajbegovic-Halimic J, Zvizdic D, Alimanovic-Halilovic E, Dodik I, Duvnjak S. Risk factors for retinopathy of prematurity in premature born children. Med Arch. 2015; 69(6): 409–13. https://doi.org/10.5455/medarh.2015.69.409-413. PMid:26843736 PMCid:PMC4720470
  • Freitas AM, Mörschbächer R, Thorell MR, Rhoden EL. Incidence and risk factors for retinopathy of prematurity: A retrospective cohort study. Int J Retina Vitreous. 2018 May 31; 4:20. https://doi.org/10.1186/s40942-018-0125-z. PMid:29881640 PMCid:PMC5984384
  • Rao KA, Purkayastha J, Hazarika M, Chaitra R, Adith KM. Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India. Indian J Ophthalmol. 2013; 61(11):640–4. https://doi.org/10.4103/0301-4738.119347. PMid:24145565 PMCid:PMC3959079

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  • Retinopathy of Prematurity Screening in a Tertiary Care Centre

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Authors

Miloni Suketu Shah
PG Resident, Department of Ophthalmology, Dr. Vasantrao Pawar Medical College and Hospital, Research Centre, Nasik – 422003, Maharashtra, India
Ajit Gulabrao Khune
Associate Professor, Department of Ophthalmology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, India
Dhiraj Namdeo Balwir
Professor and HOD, Department of Ophthalmology, Dr. Vasantrao Pawar Medical College and Hospital, Research Centre, Nashik – 422003, Maharashtra, India

Abstract


Background: To conduct an effective ROP screening program according to the Indian standard needs and to identify the infants who could benefit from treatment and make appropriate recommendations on the timing of future screening. Aims and Objectives: To estimate the incidence of ROP among Premature infants. Materials and Methods: A Prospective Observational study of 2 years in which 170 patients were screened with following criteria: GA at birth of ≤35 weeks, BW <1700 gms, exposed to oxygen >30days, other factors that can increase the risk of ROP and where screening should be considered are premature babies >37 weeks and >1700gms but with the first screening was done within 4 weeks (30 days) of life in infants with age >28 weeks of GA, 2-3 weeks after birth if GA <28 weeks or BW is <1200gms. Results: Out of the 170 babies screened 35 babies had ROP. Incidence of ROP in our study was 20.59%. The sensitivity of AAP and UKRCPCH guidelines to ours were 77.14% and 60% respectively. Conclusion: ROP may be seen in heavier and larger babies in India that have consequently a shorter window period for development of ROP, Hence, a criteria screening even larger babies should be taken into consideration.


Keywords


Birth Weight, Gestational Age, Retinopathy of Prematurity, Screening.

References





DOI: https://doi.org/10.18311/mvpjms%2F2019%2Fv6i2%2F22915