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Fanun, Monzer
- Properties of Water/Propylene Glycol/Mixed Nonionic Surfactants/Mixed Oils Microemulsions
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1 Colloids and Surfaces Research Center, Al-Quds University, 51000 East Jerusalem, PS
1 Colloids and Surfaces Research Center, Al-Quds University, 51000 East Jerusalem, PS
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Journal of Surface Science and Technology, Vol 27, No 1-2 (2011), Pagination: 1-14Abstract
Water/propylene glycol/sucrose laurate/ethoxylated mono-di-glyceride/ isopropylmyristate/peppermint oil systems were formulated and characterized. The solubilization capacity of water in the oils is dependent on the surfactants molar ratio and temperature. The microemulsions were characterized by the volumetric parameters, density, excess volume, ultrasonic velocity and isentropic compressibility. The microemulsions densities increase with the aqueous phase content up to 80 wt%, then decrease. The excess volume decreases with aqueous phase content up to 80 wt%, then stabilizes. Ultrasonic velocities increase with the increase in the aqueous phase content and decrease with temperature. Analysis of the volumetric parameters enabled the characterization of structural transition along the microemulsion phase region. The particle hydrodynamic diameter of the oil-in-water microemulsions decreases with the increase in aqueous phase content and with the increase in temperature as determined by dynamic light scattering technique.Keywords
Solubilization Capacity, Excess Volume, Ultrasonic Velocity, Isentropic Compressibility, Particle Hydrodynamic Diameter, Structural Transitions.- Water/Mixed Nonionic Surfactants/Mixed Oils Microemulsions: Characterization and Drug Solubilization
Abstract Views :280 |
PDF Views:2
Authors
Affiliations
1 Colloids and Surfaces Research Center, Al-Quds University 51000, East Jerusalem, PS
1 Colloids and Surfaces Research Center, Al-Quds University 51000, East Jerusalem, PS
Source
Journal of Surface Science and Technology, Vol 31, No 1-2 (2015), Pagination: 87-97Abstract
Water/sucrose laurate/PEG-7 glycerylcocoate/ isopropylmyristate/peppermint oil microemulsions were formulated and characterized. Water solubilization capacity in the microemulsions is dependent on both surfactants and oil ratios. Indomethacin was solubilized in the formulated systems. Drug solubility depends on the microemulsions microstructure. Electrical conductivity of the microemulsions increasesfor water content below 60-wt% then decrease for water contents above. The microemulsions were characterized also by the volumetric parameters excess volume and isentropic compressibility. Drug containing microemulsions excess volumes decrease with water content. Isentropic compressibilites increase with temperature for water contents below 60 wt% then decrease. Correlation between electrical conductivity and volumetric parameters results enabled the detection of structural transitions onset (water-in-oil to bicontinuous to oil-in-water). The particle hydrodynamic diameter of the oil-in-water microemulsions decreases with the increase in temperature.Keywords
Excess Volume, Isentropic Compressibility, Particle Hydrodynamic Diameter, Solubilization Capacity, Structural Transitions, Ultrasonic VelocityReferences
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