Journal of Surface Science and Technology

Toshikee Yadav ¹, Deepti Tikariha ¹, Jyotsna Lakra ¹, Amit K. Tiwari ², Subit K. Saha ², Kallol K. Ghosh ¹

Affiliations
1 School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.), IN
2 Department of Chemistry, Birla Institute of Technology and Science, Pilani-333 031, Rajasthan, IN

Abstract

Surface properties of two amphiphilic drugs i.e. amitriptyline and imipramine have been studied in the absence and presence of some cationic surfactants i.e. alkyltriphenylphosphonium bromide [R = 16 (CTPB), R = 14 (TTPB)] and alkyldiethylcthanolammonium bromide [R = 16 (CDEEAB), R = 14 (TDEEAB)] by surface tension measurement at 300 K. The critical micelle concentration (CMC), maximum surface excess concentration at the air/water interface (Γ_max), minimum area per surfactant molecule at the air-water interface (A_min) and the surface pressure at the CMC (π_CMC) have been determined. Γ_max value increases and CMC/π_CMC decrease & with an increasing mole fraction of surfactants. The solubility of amphiphilic drugs in cationic surfactant systems has also been studied.

Keywords

Amphiphilic Drug, Additives, Cationic Surfactant, Surface Properties, Surface Tension.

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