Journal of Surface Science and Technology

Anju Augustine ¹, Beena Mathew ¹

Affiliations
1 School of Chemical Sciences, Mahatma Gandhi University, Kottayam-686 560, Kerala, IN

Abstract

Testosterone imprinted co-polymer membranes of acrylonitrile with acrylic acid, methacrylic acid and acrylamide were synthesised by phase inversion technique. The developed membranes were characterised by FT-IR, XRD and SEM techniques. Imprinted membranes showed specificity towards the template testosterone. Among the various co-polymers, the acrylamide incorporated co-polymer showed high binding towards the used template. Investigation of the selectivity characteristics revealed that the developed membranes showed selectivity toward the template testosterone than similar compounds. The bound template could be totally recovered and regenerated membranes maintain their recognition property after repeated use. On the basis of the results, the imprinted membranes can be applied for the direct extraction of testosterone in clinical analysis.

Keywords

Molecular Imprinting, Acrylic Copolymers, Membranes, Testosterone, Binding Capacity, Urine Analysis.

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T. Sajini ¹, Beena Mathew ¹

Affiliations
1 School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala-686 560, IN

Abstract

A novel chiral sorbent for D-mandelic acid (D-MA) has been fabricated on vinyl functionalized multiwalled carbon nanotube (MWCNT) by molecular imprinting technology. Molecular imprinted polymers (MIPs) were formed by D-MA as a template molecule on the surface of the vinyl functionalized MWCNT with 4-vinyl pyridine (functional monomer) and ethylene glycol dimethacrylate (crosslinking agent) with a thermal polymerization technique. FTIR, X-ray diffraction technique (XRD) and transmission electron microscopy (TEM) were used to characterize the composite structure, morphology and determine the grafted MIP quantities in the composite. Properties like adsorption dynamics, specific binding and selective recognition capacity were evaluated. The resulting MWCNT-MIP demonstrated favorable selectivity, good stability and a higher adsorption capacity for the template molecule compared to products created by bulk polymerization. For comparison, blank polymer (MWCNT-NIP) was prepared by the same procedure, only without using the template molecule in the polymerization process. To get an insight into the role of MWCNT on chiral recognition, D-MA imprinted and non-imprinted polymers without MWCNT were also prepared.

Keywords

Chiral Recognition, D-Mandelic Acid, Molecular Imprinting, Multiwalled Carbon Nanotube.

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