Journal of Pharmaceutical Research

A. N. Kavita ¹, S. T. Pasha ², S. Ray ²

Affiliations
1 Dept. of Pharmaceutics, Krupanidhi College of Pharmacy, 12/1, Chikkabellandur, Carmelram Post, Bangalore- 560 035, IN
2 Dept. of Pharmaceutics, M. M. U. College of Pharmacy, Ramanagaram - 561 511, Karnataka, IN

Abstract

The objective of this study was to develop a multiparticulate dosage form and optimise its release profile through a novel approach employing simplex mixture design. Microparticles of Famotidine were prepared with Eudragitâ RS100, RL100 and Ethyl cellulose separately using 1:4 drug polymer ratios by emulsification solvent evaporation technique. The three master formulations were characterised for different physicochemical properties and their release profile was studied. Statistical modelling and numerical optimisation was done to predict blends of component microparticles of three polymers, which gave the desired release profile. Experimental validation of the response parameters showed only around 5% error in prediction. Thus, an accurate, economical and time saving methodology could be devised for easy and reproducible development and optimisation of multiparticulate sustained release product.

Keywords

Microparticles, Famotidine, Release optimization, Mixture Design.

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G. Chandra ¹, S. Bhattacharyya ², S. Ray ³, L. K. Ghosh ¹, B. K. Gupta ¹

Affiliations
1 Dept. of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, IN
2 Oxford College of Pharmacy, 6/9, 1st Cross, Begur Road, Hongasandra, Bangalore-560 068, IN
3 Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelram Post, Bangalore-560 035, IN

Abstract

This work aims at designing and evaluating a Extended release dosage form of Diazepam using Alginate- Eudragit RS 30D as the matrix-forming polymer employing the Ionotropic Gelation technique of micropellletization. The product was characterized by physicochemical parameters such as yield, drug entrapment efficiency, particle size, surface topography, granulometric study, loose surface crystal study, drug-excipient compatibility and in vitro release. The controlled release profile was optimized using a factorial design for achieving the correct blend of microparticles that closely matches the target release profile. The study illustrates the utility and advantage of designed experimentation in controlled drug delivery research.

Keywords

Diazepam, Extended Release, Micropellets, Factorial Design, Optimization

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