Journal of Pharmaceutical Research

S. Lakshmana Prabu ¹, N. Sivagurunathan ¹, C. Dinesh Kumar ¹, S. G. Vasantharaju ¹, B. Meenashi Vanathi ²

Affiliations
1 Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, IN
2 Shree Devi College of Pharmacy, Mangalore, Karnataka, IN

Abstract

A simple, rapid and accurate RP-HPLC method was developed for the determination of racecadotril in solid pharmaceutical dosage form. The method showed a linear response for concentrations in the range 10-200 μg/ml using methanol: water (80:20 v/v) as the mobile phase with detection at 231 nm and a flow rate of 1.2 ml/min. Solution concentrations were measured at a weight basis to avoid the use of an internal standard. The method was statistically validated for accuracy, precision, linearity, range, ruggedness, robustness, forced degradation, solution stability, and selectivity. Quantitative and recovery studies of the dosage form were also carried out and analyzed; the % RSD from recovery studies was found to be 0.53. Due to the simplicity, rapidity and accuracy of the method, we believe that the method will be useful for routine quality control analysis.

Keywords

Racecadotril, HPLC, Degradation Studies.

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S. Lakshmana Prabu ¹, Shirwaikar Arun ², Shirwaikar Annie ³, Kumar Aravind ⁴

Affiliations
1 Shasun Chemicals & Drugs Ltd., PIMS Road, Pondicherry - 605 014, IN
2 Gulf Pharmacy College, Ajman, AE
3 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, IN
4 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, IN

Abstract

The purpose of this investigation was to develop a ketoconazole cream with rosin for both topical and systemic delivery. Creams were prepared by using rosin as one of the components in different proportions with different cream base combinations. The drug excipients interaction studies were carried out and results revealed that there is no interaction between the drug and the excipients used in the formulation. The prepared creams were evaluated for their physicochemical properties, pH, viscosity, particle size, drug content and in vitro release studies. The release of the drug, ketoconazole was measured for eight hours and compared with a standard marketed formulation. The formulation (F8) fulfilled all topical formulation parameters; it can be used for the systemic topical drug delivery.

Keywords

Ketoconazole, In Vitro Release, Skin Permeation, Skin Irritation.

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S. Lakshmana Prabu ¹, Singh Tarunveer ², Dinesh Kumar ²

Affiliations
1 Anna Unviersity Tiruchirappalli, Tiruchirapalli - 620 024, Tamilnadu, IN
2 Manipal College of Pharmaceutical Sciences, Manipal, Karnataka - 576 104, IN

Abstract

A new dissolution medium was developed for the antidiarrhoeal drug, Racecadotril. The drug is poorly soluble in water; it is not official in any pharmacopoeia. In the present study was to develop a new dissolution medium for Racecadotril. The composition of the medium was selected based on the earlier information and solubility data of racecadotril at 37 ± 0.5°C. Solubility data revealed that water consisting of 3.0%w/ v sodium lauryl sulphate could be a suitable dissolution medium. The discriminating power of the selected dissolution medium relative to other dissolution mediums was evaluated and the results further justified the usage of 3.0%w/v sodium lauryl sulphate in water as dissolution medium for racecadotril.

Keywords

Racecadotril, Dissolution Medium, Sodium Lauryl Sulphate, Tween 80.

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T . N. K. Suriyaprakash ¹, S. Lakshmana Prabu ², A. Sumathi ¹

Affiliations
1 Dept of Pharmaceutics, Periyar College of Pharmaceutical Sciences, Trichy – 620 021, IN
2 Dept. of Pharm. Technology, Anna University of Technology, Tiruchirappalli – 620 024, IN

Abstract

Tuberculosis is one of a disease that has afflicted the human race for centuries by Mycobacterium tuberculosis. Highly effective drugs for treating TB were introduced over 40 years ago, yet deaths from the disease continue to increase. Agents that reduce the duration and complexity of the current therapy would have a major impact on compliance and overall cure rate. Thus, many potential drug targets have been identified, dozens of vaccine candidates have been tested in animal models in recent years, and several of these are poised to move into clinical trials in the next several years. The overall goals for treatment of tuberculosis are 1) to cure the individual patient, and 2) to minimize the transmission of M. tuberculosis to other persons. Thus, successful treatment of tuberculosis has benefits both for the individual patient and the community in which the patient resides, but in all cases the health department is ultimately responsible for ensuring that adequate, appropriate diagnostic and treatment services are available, and for monitoring the results of therapy. This article provides a comprehensive review about the science of tuberculosis, types, diagnosis and its evaluation techniques and treatment procedures.

Keywords

Tuberculosis, Mycobacterium, AIDS, DOTS, MDR-TB.

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