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Sudheer, Preethi
- Self Emulsifying Drug Delivery System - An Innovative Approch for Enhacement of Solubility and Therapeutic Potential
Authors
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 4 (2016), Pagination: 153-161Abstract
Purpose: As the development of modern drug discovery techniques, there has been increase in the number of pharmaceutical compounds that are poorly water soluble. These lipophilic compounds possess low dissolution rate and therefore low bioavailability. The Formulation scientists should adopt various strategies to enhance their absorption. This paper is an insight for improving the solubility of poorly water soluble compounds.
Approach: Lipidic formulations are found to be a promising approach to combat the solubility challenges. Self Micro Emulsifying Drug Delivery Systems (SMEDDS) are gaining more attention for improving the solubility of the lipophilic drugs.
Findings: SMEDDS are isotropic mixtures of oil, surfactant and co surfactant and are vital tool in solving low bioavailability problems of poorly soluble drugs. Lipophilic drugs can be dissolved in these systems, enabling them to be administered per orally. When this is released into the lumen it results in w/o microemulsion with the aid of G.I fluid.
Conclusion: This present review describes various formulation components, mechanism of emulsification, biopharm aspects, characterization methods and application of SMEDDS.
Keywords
Surfactants, Solubility, SMEDDS, Microemulsion.References
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- A Review:Solid Dispersion, a Technique of Solubility Enhancement
Authors
1 Krupanidhi College of Pharmacy, Chikkabellandur Village, Carmelaram Post, Varthur Hobli, Bangalore - 560035, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 1 (2017), Pagination: 25-31Abstract
Purpose: The aim of the study was to explore the necessity, advantages and different techniques of solid dispersion for enhancing solubility of poorly soluble drugs.
Approach: Different types of solid dispersion have been explained briefly along with the various techniques of solid dispersion in detail.
Findings: Solid dispersions of poorly soluble drugs have been found to give positive results in enhancing its solubility and dissolution characters.
Conclusion: Solid dispersion techniques improve solubility and bioavailability of poorly soluble drugs. Solid dispersions can be incorporated into various dosage forms with wide range of applicability.
Keywords
Solid Dispersion Techniques, Solubility, Advantages, Disadvantages, Carriers.References
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- Solid Lipid Nanoparticles- An Innovative Approach for Improving the Solubility and Bioavailability
Authors
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 2 (2017), Pagination: 148-153Abstract
Purpose: The purpose of this study is to give a general review on solid lipid nanoparticles (SLNs) as a novel drug carrier for improving the solubility and bioavailability of drugs.
Approach: Among the various colloidal drug carriers, SLNs have been emerged as next generation drug delivery system for incorporating lipophilic drugs. They are relatively nontoxic and nonirritant. The review insight on the various methods of preparation, characterization and also the application of SLNs for improving the solubility and bioavailability is explained here.
Findings: SLNs is used as a novel carrier for improving the solubility of poorly soluble drugs which may results in enhanced bioavailability and stability of drug can also be improved by incorporating drug in the form of solid lipid nanoparticles.
Conclusion: This review presents an overview of SLNs which includes SLN and its properties, excipients, techniques used in preparation of SLNs, characterization, and their applications.
Keywords
Bioavailability, Solubility, Lipophilic, Stability, Advantages, Disadvantages.References
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- Mucoadhesive Polymers:A Review
Authors
1 Department of Pharmaceutics, 12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore-560035, IN
Source
Journal of Pharmaceutical Research, Vol 17, No 1 (2018), Pagination: 47-55Abstract
Purpose: Aim of the study is to explore the concept of mucoadhesion, theories and the various polymers used in mucoadhesive drug delivery. Approach: An extensive review is carried out on mechanism of mucoadhesion, theories, polymers used in mucoadhesive dosage forms and its applications. Finding: Mucoadhesive polymers increases the residence time, prolongs the absorption, enhances solubility and dissolution characteristics of poorly soluble drugs. Conclusion: Mucoadhesive polymers was found to be a novel drug carrier used in buccal, nasal, vaginal, ocular, rectal drug delivery which improves bioavailability of poorly soluble drugs.Keywords
Mucoadhesive Polymer, Mucoadhesion, Bioavailability.References
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