Journal of Pharmaceutical Research

Nayak Bhabani Shankar ¹, Jena Prabhat Kumar ¹, Sahu Nigam Prasad ¹, P. Ellaiah ¹

Affiliations
1 Department of Pharmacognosy, Jeypore College of Pharmacy, Rondapalli, Jeypore - 764 002, Koraput, Orissa, IN

Abstract

Solanum surattense Linn is found in the tribal area of Koraput district and extensively used traditionally by the tribal people as anthelmintic, diuretic, antiarrhythmic, hypotensive, expectorant and carminative. The present study is an attempt to explore the anthelmintic activity of ethanolic extract of fruits of plant Solanum surattense. Thin Layer Chromatography study was done to confirm whether the bioactive fraction or single constituent of plant crude extract is showing anthelmintic activity. The various doses of ethanolic extracts were evaluated for their anthelmintic activities on adult Indian earthworms, Pheretima postuma. All extracts were able to show anthelmintic activity at 10 mg/ml concentration. The activities are comparable with the standard drugs, Piperazine citrate and Albendazole. All the doses of ethanolic extract of Solanum surattense showed better anthelmintic activity than the standard drugs. When the dose of the extract was increased, a gradual increase in anthelmintic activity was observed. The data were found statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05).

Keywords

Solanum surattense, Solanaceae, Anthelmintic, Piperazine Citrate, Albindazole.

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Mishra Debidani ¹, S. Ramakrishna ², Nayak Bhabani Shankar ¹, P. Ellaiah ¹

Affiliations
1 Department of Pharmacognosy, Faculty of Pharmacy, Jeypore College of Pharmacy, Rondapalli, Jeypore - 764002, Koraput, Odisha, IN
2 Department of Pharmacognosy, Faculty of Pharmacy, College of Pharmaceutical Sciences, Mohuda, Berhampur – 760002, Odisha, IN

Abstract

Eupatorium odoratum Linn is found in the tribal area of Baipariguda (Dist: Koraput) and extensively used traditionally by the tribal people as anthelmintic, antibacterial, antifungal and wound healing agent. The present study is an attempt to preliminary investigation of phytochemical constituents and to explore the wound healing property of the ointments prepared from solvent extracts (Petroleum ether, ethanol and chloroform). The phytochemical studies indicated that the tests for alkaloids, tannins and phenolic compounds were positive while the tests for anthraquinone glycosides, proteins, amino acids and saponins were negative for all extracts. Other chemical tests exhibited varying results. The various doses of ointment extracts were evaluated for their wound healing activities on healthy Wistar rats by excision wound models. All extracts showed wound healing activity and activities are well compared with the standard drugs (neosporin and betadine). When the dose of the extract is increased, a gradual increase in wound healing activity was observed. Among all the extracts (ointments), ethanolic extract containing ointment showed better wound healing activity over the others and even in comparison to standard drugs.

Keywords

Eupatorium odoratum, Wound Healing, Phenolic Compounds.

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