Journal of Pharmaceutical Research

M. U. Adikwu ¹, O. Okorie ², A. A. Attama ¹

Affiliations
1 Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, NG
2 Department of Pharmaceutical Technology & Industrial Pharmacy, University of Nigeria, Nsukka 410001, NG

Abstract

The pharmacodynamic effects of metformin in a mucoadhesive delivery system of detarium gum are presented. The gum compacts alone without the drug showed blood glucose lowering capacity. The combinations showed marked antidiabetic effect in streptozotocin-induced diabetic rat models.

Keywords

Pharmacodynamics, Metformin, Detarium Gum, Mucoadhesive.

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O. Okorie ¹, C. N. E. Ibezim ²

Affiliations
1 Department of pharmaceutics and pharmaceutical technology, Faculty of pharmaceutical sciences, University of Port Harcourt (+234), Rivers State, NG
2 Department of pharmaceutics and pharmaceutical technology, Faculty of pharmaceutical sciences, University of Port Harcourt (+234), Rivers State, IN

Abstract

Microcrystalline cellulose (MCC), a purified, partially depolymerized cellulose remains the most widely used direct compression excipient in pharmaceutical industry. It is prepared by treating alpha-cellulose obtained as a pulp from tender shoot of Bambosa Vulgaris with 2.5N hydrochloric acid and subsequent bleaching with 0.1N sodium hypochlorite, heated to 50°C for 30mins. Results obtained showed a yield of 64% microcrystalline cellulose. It is a whitish, odorless, tasteless crystalline powder. Its direct compression and binding properties were compared with those of fine grade microcrystalline cellulose (Avicel PH 101). At concentration ratios of 60:40(new MCC : Ascorbic acid), friability showed anconcentration ratio. Though Hausner quocient of 1.24 and percent compressibility of 20.02 indicates that this new MCC does have fairly good flow properties, it has been shown to possess a potentially good binding characteristics without addition of other excipients.

Keywords

Microcrystalline cellulose (MCC), Bambosa vulgaris, Compressibility

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O. Okorie ¹, C. N. E. Ibezim ¹, N. Nwachukwu ¹

Affiliations
1 Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, NG

Abstract

The suspending property of a new polysaccharide gum derived from Afzelia Africana (family Fabaceae) seed have been investigated using Sodium carboxymethylcellulose as reference standard. Deflocculated and flocculated(using 1% solution of Aluminium Chloride) Zinc oxide suspensions were prepared using 0.5%w/v,1.0%w/v,2%w/v and 4%w/v of Afzelia africana gum, sodium carboxymethylcellulose and binary(1:1) combinations of the polymers. Suspension stability was evaluated by comparing the rheological behavior, sedimentation volume and degree of flocculation. The study revealed that a 2% w/v binary combination system exhibited better rheological properties, highest degree of flocculation, increased sedimentation volume and reduced settling in comparison with other concentration of the same system as well as other suspending agents alone.

Keywords

Afzelia Africana Gum (AAG), Zinc Oxide Suspension, Flocculation, Deflocculation, Sedimentation Volume, Sodium Carboxymethylcellulose (SCMC).

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