Journal of Pharmaceutical Research

S. S. Patel ¹, M. S. Patel ¹, N. M. Patel ¹

Affiliations
1 Department of Pharmaceutical Technology, Shri B.M.Shah College of Pharmaceutical Education and Research, Dhansura Road, Modasa-383315, Gujarat, IN

Abstract

Flowability and packability of thirteen commercially available, direct compression excipients, Avicel CE-15, Prosolv SMCC HD-90, Prosolv SMCCTM-90, Tablettose 80, Flowlac 100, Cellactose 80, Microcelac 100, Ludipress, Ludipress-LCE, Emcompress, Starch 1500 G, Era Tab and Maize starch-B were examined according to the technical procedure described in the current British Pharmacopoeia. Results revealed unfavorable properties for Ludipress compared to other substances. Ludipress, however, appeared macroscopically to be of extremely pronounced free flowing properties. This contraindication was studied in more detail, proposing to express powder flow in terms of volume per time unit rather than mass time unit (Volume-flowability). Avicel CE-15, Starch 1500 G, Era Tab and Maize starch B exhibited "poor" flow property.

Keywords

Compressibility, Volume Flowability, Kawakita Constant, Directly Compressible Excipients.

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V. G. Brahmbhatt ¹, N. M. Patel ¹, M. R. Patel ¹, K. R. Patel ¹

Affiliations
1 Department of Pharmaceutics, Shri B.M.Shah College of Pharmaceutical Education and Research, Modasa (S.K.), Gujarat - 383 315, IN

Abstract

In the present investigation solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X₁) crospovidone(X₂), and sodium starch glycolate(X₃) in tablet formulation. Disintegration time and T₅₀ (Time required to 50% drug release) taken as responses. Solid dispersion showed significant enhancement in solubility of olanzapine. For mouth dissolving tablet, batch containing 5% croscarmellose sodium alone had minimum disintegration time (44 sec.) and faster drug release (T₅₀: 40 sec) compared to other batches.

Keywords

Olanzapine, Solid Dispersion, Solubility, Mouth Dissolving Tablet, Disintegration.

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