Journal of Pharmaceutical Research

Abstract

Objective: The main objective of present study was to formulate and evaluate methyl cellulose based in situ gel of rosuvastatin for the treatment of periodontal diseases.

Methods: The rosuvastatin in situ gel was prepared by using different concentration of methyl cellulose as gel base and gel was evaluated for pH, viscosity, rheology, drug content, syringeability, spreadability, drug release and drug release kinetics studies.

Results: Compatibility study was performed using FT-IR and results showed there was no interaction between drug and other excipients. Viscosity of all formulations was found in the range of 320-590 centipoise and all formulations exhibited shear thinning pseudoplastic behaviour. Gelation time and temperature was found in the range of 2-15 min and 26°C-39°C respectively. All the formulation except formulation F6, F7 and G8 passed syringeabilitytest, as these formulations easily gets expelled from the syringe. An in vitro release study was conducted using 1.2 pH buffer for 8 hours and results showed that formulation F5 containing 0.9% methyl cellulose was considered as optimum formulation as it released 54.33% drug at the end 8 hours. In vitro release study revealed that release rate of drug from the in situ gel was concentration dependent; as concentration of methyl cellulose increased the drug release rate was retarded.

Conclusion: Thus, it can be concluded that formulation F5 containing 0.9%w/v of methyl cellulose as gel base was considered as an optimized formulation, as it release drug in sustain manner in the treatment of periodontal diseases.

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Abstract

Purpose: Gastric retentive drug delivery devices can be used for controlled drug delivery systems containing drugs, which are degraded in the colon. The main objective of the present study is to design and formulate gastric retentive controlled release dosage form of bisoprolol fumarate in order to improve the gastric residence time, which in turn increases its bioavailability.

Approach: Floating dosage form of bisoprolol fumarate was prepared by direct compression method using different concentration and grades of hydroxypropyl methylcellulose and sodium bicarbonate. Prepared powder mixtures and tablets were subjected to various pre-compression and post-compression evaluations respectively.

Findings: Powder mixture showed good flow properties for uniform die filling. The SEM analysis showed minimum number of pores and erosion on the surface of the tablet. The optimized formulation F8 gave floating lag time less than 3 min with a floating time of 12 h, and an in vitro release profile very near to the desired release. The prepared dosage form reported to follow the zero order release and non-Fickian mechanism. Best formulations were subjected to accelerated stability studies. The assay results showed that the drug was stable for 3 months without any change in the drug content.

Conclusion: Finally it can be concluded that the gastric retentive time of bisoprolol can be increased by formulating it in a floating dosage form.

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