Journal of Pharmaceutical Research

V. Niraimathi ¹, C. Vamsadhara ¹, Lata Sriram ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, IN

Abstract

2-hetero substituted-4-quinazolone derivatives attract a wide spread interest due to the diverse biological activities. Six novel 2-heterosubstituted quinazolones were synthesized and the structures were assigned on the basis of spectral data. These compounds were screened for their antimicrobial activity. The recorded zone of inhibition showed significant broad spectrum antibacterial activity when compared with standard ciprofloxacin. Antifungal screening indicated that all the synthesized moieties had inhibitory effect against the tested pathogenic fungi.

Keywords

Quinazolone, Antimicrobial Activity.

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V. Niraimathi ¹, A. Jerad Suresh ¹, Lata Sriram ¹, T. Latha ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, IN

Abstract

A novel series of azomethines of aryl oxazoles were synthesised and investigated for their antimicrobial activity against Gram positive and Gram negative bacteria using antibiotic diffusion method. The recorded data of zone of inhibition showed significant broad activity when compared with standard. The sensitivity of the Gram positive bacteria to the tested compounds was higher than that of Gram negative bacteria. The synthesised compounds were also screened for antifungal activity and observed that they had an inhibitory effect against the pathogenic fungi.

Keywords

Oxazoles, Azomethines, Antibacterial Activity, Antifungal Activity.

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