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Authors
Affiliations
1 Shasun Chemicals & Drugs Ltd., PIMS Road, Pondicherry - 605 014, IN
2 Gulf Pharmacy College, Ajman, AE
3 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, IN
4 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, IN
Source
Journal of Pharmaceutical Research, Vol 8, No 2 (2009), Pagination: 89-92
Abstract
The purpose of this investigation was to develop a ketoconazole cream with rosin for both topical and systemic delivery. Creams were prepared by using rosin as one of the components in different proportions with different cream base combinations. The drug excipients interaction studies were carried out and results revealed that there is no interaction between the drug and the excipients used in the formulation. The prepared creams were evaluated for their physicochemical properties, pH, viscosity, particle size, drug content and in vitro release studies. The release of the drug, ketoconazole was measured for eight hours and compared with a standard marketed formulation. The formulation (F8) fulfilled all topical formulation parameters; it can be used for the systemic topical drug delivery.
Keywords
Ketoconazole, In Vitro Release, Skin Permeation, Skin Irritation.
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