A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Reddy, Kavitha
- Enhancing the Solubility of BCS Class II and IV Drugs by Sedds Approach-A Structured Review
Authors
1 Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 4 (2016), Pagination: 174-180Abstract
Purpose: The solubility of orally administered hydrophobic drugs ismajor challenge for pharmaceutical formulators as nearly 35-40% of newly launched drugs possess low aqueous solubility which leads to poor dissolution and low bioavailability, resulting in high intra&inter subject variability&lack of dose proportionality.
Approach: Self-Emulsifying Drug Delivery System, (SEDDS) is gaining popularity for improving the solubility of lipophilic drugs. Therefore, various formulation strategies have been investigated to improve the solubility and the rate of dissolution to enhance the oral bioavailability of lipophilic drugs.
Finding: This review mainly discusses about the mechanism of SEDDS, excipient used in SEEDS, dosage forms, evaluation, applications, advantages and drawbacks.
Conclusion: SEDDS form fine emulsions (or micro-emulsions) in gastro-intestinal tract (GIT) with mild agitation provided by gastric mobility. Many parameters like surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge plays a critical role in oral absorption of drug from SEEDS.
Keywords
SEDDS, Hydrophobic Drugs, Micro Emulsion, Lipid Based System.Full Text
References
- Kumar A, Sharma S, Kamble R. Selfemulsifying drug delivery system (SEDDS): future aspects. Int J Pharm Pharm Sci. 2010; 2 (Suppl 4):713.
- Garrigue JS, Lambert G, Benita S. Selfemulsifying oral lipid-based formulations for improved delivery of lipophilic drugs. Microencapsulation: Methods and Industrial Applications. 2006:429-80.
- Wakerly MG, Pouton CW, Meakin BJ. Evaluation of the self-emulsifying performance of a non-ionic surfactantvegetable oil mixture. J Pharm Pharmacol. 1987;39(6):b70.
- Craig D. The use of self-emulsifying systems as a means of improving drug delivery. Bulletin Technique-Gattefosse. 1993:21-32.
- Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. International journal of pharmaceutics. 1994 May 16;106(1):15-23.
- Craig DQ, Lievens HS, Pitt KG, Storey DE. An investigation into the physico-chemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis. International journal of pharmaceutics. 1993 Jul 31;96(1-3):147-55.
- Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko FJ, Pouton CW. Selfemulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharmaceutical research. 1992 Jan 1;9(1):87-93.
- Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharmaceutical research. 1995 Nov 1;12(11):1561-72.
- Pouton CW. Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification. International Journal of Pharmaceutics. 1985 Dec 31;27(2):335-48.
- Nigade PM, Patil SL, Tiwari SS. Self Emulsifying drug delivery system (SEDDS): A review. International Journal of Pharmacy and Biological Sciences. 2012 Apr;2(2):42-52.
- Kommuru TR, Gurley B, Khan MA, Reddy IK. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q 10: formulation development and bioavailability assessment. International journal of pharmaceutics. 2001 Jan 16;212(2):233-46.
- Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. International journal of pharmaceutics. 1994 May 16;106(1):15-23.
- Pouton CW. Effects of the inclusion of a model drug on the performance of self emulsifying formulations. Journal of pharmacy and Pharmacology. 1985 Dec 1;37(S12).
- Patil P, Patil V, Paradkar A. Formulation of a self-emulsifying system for oral delivery of simvastatin: in vitro and in vivo evaluation. Acta pharmaceutica. 2007 Mar 1;57(1):111-22.
- Karim A, Gokhale R, Cole M, Sherman J, Yeramian P, Bryant M, Franke H. HIV protease inhibitor SC-52151: a novel method of optimizing bioavailability profile.