Journal of Pharmaceutical Research

B. Srivastava ¹, J. Akhtar ¹, U. S. Baghel ¹

Affiliations
1 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur - 302025. Rajasthan, IN

Abstract

A method for the simultaneous determination of rabeprazole sodium and domperidone maleate in bulk and capsule dosage form was developed. The method employs formation and solving of simultaneous equations using 259.4 and 284.4 nm as two analytical wavelengths. The absorbance maxima of rabeprazole sodium and domperidone maleate were found to be 259.4 nm and 284.4 nm respectively in 0.1N H₂SO₄. The linearity range lies between 4-40 μg/ml for rabeprazole sodium and 5-35 μg/ml for domperidone maleate at their respective wavelength. Both the drugs obey Beer's law. The molar absorptivity and sandell's sensitivity were found to be 8.87×103and 0.0431 respectively for Rabeprazole sodium and for Domperidone maleate 9.99×103 and 0.0427 respectively. The recovery studies confirmed the accuracy of the developed method.

Keywords

Simultaneous Equation, Simultaneous Estimation, Rabeprazole Sodium, Domperidone Maleate.

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B. Srivastava ¹, P. D. Bhatt ¹, J. Akhtar ¹

Affiliations
1 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-302 025, Rajasthan, IN

Abstract

A method for the simultaneous determination of hydrochlorothiazide and candesartan cilexetil in bulk and tablet dosage form was developed. The method employs formation and solving of simultaneous equations using 225.8 and 255 nm as two analytical wavelengths. The absorbance maxima of hydrochlorothiazide and candesartan cilexetil were found to be 225.8 nm and 255 nm respectively in methanol. The linearity range lies between 1-7 μg/ml for hydrochlorothiazide and 2-10 μg/ml for candesartan cilexetil at their respective wavelength. Both the drugs obey Beer's law. The molar absorptivity and sandell's sensitivity were found to be 4.11×10⁴ and 0.0073 respectively for Hydrochlorothiazide and for Candesartan cilexetil 6.21×10⁴ and 0.0098 respectively. The recovery studies confirmed the accuracy of the developed method.

Keywords

Simultaneous Equation, Simultaneous Estimation, Hydrochlorothiazide, Candesartan Cilexetil.

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