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Charan, C. S.
- Ameliorative Effects of Roots of Asparagus adscendens Roxb. on Cognitive Impairments and Brain Aging Induced by Scopolamine and Diazepam in Animal Models Relevant to Alzheimer's Disease
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Authors
Affiliations
1 Department of Postgraduate studies and Research, Division of Pharmacognosy and Photochemistry, Sarada Vilas College of Pharmacy, K. M. Puram, Mysore, Karnataka, IN
1 Department of Postgraduate studies and Research, Division of Pharmacognosy and Photochemistry, Sarada Vilas College of Pharmacy, K. M. Puram, Mysore, Karnataka, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 3 (2017), Pagination: 199-207Abstract
Memory loss in dementia is often the most disabling feature of many disorders, impairing the normal daily activities of the patients and profoundly affecting their families. Treatment of cognitive disorders like dementia and Alzheimer's disease has been challenging since no potential drug is available at present with proved efficacy. In the present study, nootropic activity of methanolic extract of ischolar_mains of Asparagus adscendens Roxb.(AR) was studied in mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory. Scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.) were used to induce amnesia in mice. AR (50 and 100 mg/kg, p.o.) significantly attenuated amnesic deficits induced by scopolamine, diazepam and natural aging. Furthermore, it also reversed aging induced amnesia due to natural aging of mice. AR profoundly increased whole brain acetyl cholinesterase inhibition activity. Hence, AR might prove to be a useful memory restorative agent in the treatment of dementia seen in the elderly. The underlying mechanism of its action may be attributed to its antioxidant and acetyl cholinesterase inhibition properties.Keywords
Acetyl cholinesterase, Asparagus adscendens, Dementia, Memory, Scopolamine.Full Text
References
- Rowan M.Information-selectivity of Beta-amyloid pathology in an associative memory model.Frontiers in Computational Neuroscience. 2012; 6: 2-16.
- Drngenberg HC. Alzheimer's disease: more than a 'cholinergic disorder'- evidence that cholinergic-monoaminergic interactions contribute to EEG slowing and dementia. Behavioral Brain Research, 2000; 115: 235-239.
- Robert K, Kawas C. Risk factors for Alzheimer's disease. Neuro Science News 1998; 1: 27-44.
- Youdim K, Joseph JA. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radical Biology and Medicine. 2000; 30: 583-588.
- Kalache A, Aboderin I, Hoskins I. Compression of morbidity and active ageing; key priorities for public health policy in the 21st century. Bulletin of the World Health Organization 2002; 80: 179-184.
- Doody RS, Stevens JC, Beck RN, Dubinsky RM, Koye JA, Gwyther L. Practice parameters: Management of dementia (an evidence based review)-report of the quality standards subcommittee of the American Academy of Neurology. Neurology 2001; 56: 1154-1161.
- Herbert LE, Scherr PA, Bienias JL, Bennett DA, Evans. Alzheimer Disease in the U.S. Population: Prevalence Estimates Using the 2000 Census. Archives Neurol 2003; 60: 11-19.
- Schever K, Rostock A, Bartsch P, Muller WK. Piracetam improved cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry 1999;32: 10.
- Cumin R, Bandle EF, Gamzu E, Haefely EW. Effects of the novel compound aniracetam (Ro-13-5057) upon impaired learning and memory in rodents. Psychopharmacology 1982; 78: 104.
- Rogers EJ, Milhalik S, Ortiz D, Shea TB. Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice. Journal Nutr. Health Aging 2003; 7: 1-6.
- Sharma PV. Dravya guna vijnan, 1982; .2nd ed., Chaukambha Bharati Academy, Varanasi, 562.
- Goyal R, Singh J and Lal H. Asparagus racemosus--an update. Indian journal of medical sciences. 2003; 57: 408-410.
- Hayes PY, Jahidin AH, Lehmann R, Penman K, Kitching W, De Voss JJ. Steroidal saponins from the ischolar_mains of Asparagus racemosus. Phytochemistry 2008; 69: 796804.
- Chauhan N.S. Medicinal and aromatic plants of Himachal Pradesh. Indus Publishing., 1999;22-24.
- Bansode FW, Arya KR, Singh RK, Narender T. Dose-dependent effects of Asparagus adscendens ischolar_main (AARR) extract on the anabolic, reproductive, and sexual behavioral activity in rats. Pharmaceutical biology 2014;6: 1-9.
- Parle M ·, Dhingra D, Kulkarni SK. Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models. Journal of Medicinal FoodHYPERLINK "https://www.google.co.in/url?sa=t&rct=j &q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwjj3uXgh qrSAhXLmpQKHc6JAeEQFggeMAA&url=http%3A%2F%2Fwww.liebertpub.co m%2Foverview%2Fjournal-of-medicinal-food%2F38%2F&usg=AFQjCNG2KfEdDuYPOcl40Kf_AEGPF-C0w&sig2=bjkHH9Ubjtxs4vvgY2c3BQ&bvm=bv.148073327,d.dGo"HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/ 15671690". 2004; 7(4):462.
- Organization for Economic Co-operation and Development 2001. Guideline 423.Acute oral toxicity.[https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/ oecd/oecd_gl423.pdf]orDiener, W; U Mischke, E Schlede and D Kayser (1995). The biometric evaluation of the OECDmodified version of the acute toxic category method (oral). Arch.Toxicol. 69: 729-734.
- Itoh J, Nabeshima T, Kameyama T. Utility of an elevated plus maze for the evaluation of nootropics, scopolamine and electro convulsive shock. Psychopharmacology 1990; 101: 27-33.
- Parle M, Dhingra D. Ascorbic acid: a promising memory enhancer in mice. Journal of Pharmaceutical Sciences.2003; 93: 129-135.
- Biradar SM, Joshi H, Chheda TK. Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease.European Journal of Pharmacology. 2012; 683(1-3):140147.
- Joshi H, Mittal Bhadania . Evaluation of freeze dried extract of mentha piperita in management of cognitive dysfunctions in mice.Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2014; 10( 4): 461-462.
- Joshi H, Parle M. Nardostachys jatamansi improves learning and memory in mice. Journal of Medicinal Food . 2006; 9: 113-118.
- Joshi H, Parle M. Effects of piperine on memory and behavior mediated via monoamine neurotransmitters. J Trad Med. 2005; 2: 39-43.
- Joshi H, Parle M.Evaluation of nootropic potential of Ocimum Sanctum Linn. in mice. Indian J Expt Biol. 2006; 44: 133-136.
- Ellman GL, Courtney KD, Valentino A, Featherstone RM. A new and rapid colourimetric determination of acetylcholinestrase activity. Biochem Pharmacol. 1961;7: 88-95.
- Jay Ellis M. Cholinesterase inhibitors in the treatment of dementia. Journal of the American Osteopathic Association. 2005; 3: 145-158.
- Ghelardini C, Galeotti N, Barboloni A, Furukawa S. Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the acetylcholine releaser PG-9. Japanese J Pharmacol. 1998; 78: 245.