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De Chaudhuri, Sujata
- Chronic Exposure to Heavy Metals Declines Sperm Quality and Damages Tissue Architecture
Abstract Views :163 |
PDF Views:81
Authors
Affiliations
1 Department of Zoology, Barrackpore Rastraguru Surendranath College, Barrackpore, Kolkata – 700120, West Bengal, IN
1 Department of Zoology, Barrackpore Rastraguru Surendranath College, Barrackpore, Kolkata – 700120, West Bengal, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 22, No 3 (2022), Pagination: 117-121Abstract
This study aimed to assess the toxic effects of heavy metals in adult male rats after chronic exposure in early life stages. Juvenile male Wistar rats were kept in constant supply of drinking water having heavy metal salts such as Sodium Arsenite, Cadmium Chloride and Lead Acetate of dose 100 times higher than Maximum Contamination Limit (MCL; laid done by US EPA, 2009) for 3 months along with control rats with a supply of heavy metal free water. The result showed decreased sperm count and increase in abnormal sperm in all treated cases. Histopathology showed that testes and liver tissues of treated rats were severely damaged. Thus, this study showed that chronic exposure to heavy metals such as Arsenic, Cadmium and Lead in juvenile period may result in reduced reproductive capacity at later stage of life.Keywords
Heavy Metal, Live, Male Rats, Reproduction, TestisFull Text
References
- Agency for Toxic Substances and Disease Registry. Atlanta (ATSDR). Toxicological profile for arsenic 2007 [displayed 3 January 2012].
- Agency for Toxic Substances and Disease Registry (ATSDR).
- Public Health Statement for Cadmium, September 2008 [displayed 3 January 2012]. Available at http://www.atsdr.cdc.gov/ phs/phs.asp?id=46&tid=15
- Agency for Toxic Substances and Disease Registry (ATSDR).
- Toxicological profile for lead 2007 [displayed 3 January 2012] Available at http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf
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- Sarkar M, Chaudhuri G, Chattopadhayay A, Biswas NM. Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J Androl. 2003 Mar; 5:27–31.
- Thompson J, Bannigan J. Cadmium: Toxic effects on the reproductive system and the embryo. Reprod Toxicol. 2008 Apr; 25(3):304–15. PMid: 18367374. https://doi.org/10.1016/j.reprotox.2008.02.001
- Mukhopadhyay D, Mitra A, Nandi P, Varghese AC, Murmu N, Chowdhury R, Chaudhuri K, Bhattacharyya AK.
- Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection. Syst Biol Reprod Med.
- Nov; 55(5-6):188–92. PMid: 19938953. https://doi.
- org/10.3109/19396360903114429
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- De Chaudhuri S, Kundu M, Banerjee M, Das JK, Majumdar P, Basu S, Roychoudhury S, Keshav K, Singh KK, Giri AK.
- Arsenic-induced health effects and genetic damage in keratotic individuals: Involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility. Mutat Res. 2008 Nov 26; 659(1-2):118–25. PMid: 18249029. https://doi.org/10.1016/j.
- mrrev.2007.11.008
- Goyal T, Mitra P, Singh P, Sharma S, Sharma P. Assessement of blood lead and cadmium levels in occupationally exposed workers of Jodhpur, Rajasthan. Indian J Clin Biochem. 2021 Jan; 36(1):100–7. PMid: 33505134 PMCid: PMC7817726. https://doi.
- org/10.1007/s12291-020-00878-6
- World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus
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- Roy Chowdhury A, Rao RV, Gautam AK. Histochemical changes in the testes of lead induced experimental rats. Folia Histochem Et Cytobiol. 1986 Jan; 24(3):233–8.
- Roy Chowdhury A, Chinoy NJ, Gautam AK, Rao RV, Parikh DJ, Shah GM, Highland HN, Patel KG, Chatterjee BB. Effect of lead on human semen. Advances in Contraceptive Delivery System.
- Jun; 2(2-3):208–10.
- Ground Water Arsenic Causes Premature Senescence in Population from Gangetic Basin, India
Abstract Views :125 |
PDF Views:76
Authors
Affiliations
1 Department of Zoology, Barrackpore Rastraguru Surendranath College, Barrackpore, Kolkata – 700120, West Bengal, IN
1 Department of Zoology, Barrackpore Rastraguru Surendranath College, Barrackpore, Kolkata – 700120, West Bengal, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 23, No 2 (2023), Pagination: 67-70Abstract
Groundwater arsenic is the main public health concern in the Indo-Bangladesh Gangetic basin. Much work has been done on the carcinogenic effect of arsenic. Compared to that other cellular effects, cellular senescence in the human system was not studied. Replicative senescence that occurs by the gradual shortening of telomeres, and other cellular changes, is characteristic of human somatic cells. Premature senescence, characterized by increased beta-galactosidase activity; abnormal decrease in telomere length may also be the effect of arsenic. The objective of this study was to know whether premature senescence in the human cellular system can be induced by arsenic. Human cases were selected from the arsenic-affected district (Murshidabad), and controls were taken from the unaffected district (East Midnapore) of West Bengal. Senescence-associated beta-galactosidase in cell and telomere length measured by Southern blotting by DIG-labelled chemiluminescence method was conducted. The result indicated that arsenic causes premature cellular senescence in the human system.Keywords
Arsenic, SA-beta-Gal, Senescence, Telomere, Terminal Restriction FragmentFull Text
References
- Agency for Toxic Substances and Disease Registry. Atlanta (ATSDR). Toxicological profile for arsenic; 2021. Available at: https://www.atsdr.cdc.gov/.
- US EPA. Basic information about arsenic in drinking water; 2023. Available at: http://water.epa.gov/drink/contaminants/index.cfm
- Sujata De Chaudhuri, Manjari Kundu, Mayukh Banerjee, Jayanta K. Das, Papiya Majumdar, Santanu Basu, et al. Arsenic-induced health effects and genetic damage in keratotic individuals: Involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility. Mutat Res. 2008; 659(1-2):118–25. https://doi.org/10.1016/j.mrrev.2007.11.008
- Liu L, Trimarchi JR, Navarro P, Blasco MA, Keefe DL. Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis. J Biol Chem. 2003; 278(34):31998–32004. https://doi.org/10.1074/jbc.M303553200
- Kurz DJ, Decary S, Hong , Erusalimsky JD. Senescence-associated beta-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells.. J Cell Sci. 2000; 113:3613–22. https://doi.org/10.1242/jcs.113.20.3613
- Zhang TC, Schmitt MT, Mumford JM. Effects of arsenic on telomerase and telomeres in relation to cell proliferatio and apoptosis in human keratinocytes and leukemia cells in vitro. Carcinogenesis. 2003; (24):1811–17. https://doi.org/10.1093/carcin/ bgg141
- Zhang Y, Cao EH, Liang XQ, Qin JF. Increasing sensitivity to arsenic trioxide-induced apoptosis by altered telomere state. Eur J Pharmacol. 2003; 474(2-3):141–7. https://doi.org/10.1016/S0014-2999(03)02013-2
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