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Arshad, Md
- Role of Interleukin-I Super Family in Progression of Osteoarthritis
Abstract Views :224 |
PDF Views:129
Authors
Amit Kumar
1,
Md Arshad
2,
Ajai Singh
3,
Asif Jafri
4,
Sabir Ali
5,
Manish Yadav
5,
Suchit Swaroop
1
Affiliations
1 Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
2 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow – 226003, IN
4 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
5 Department of Orthopedics, King George Medical University, Lucknow – 226003, IN
1 Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
2 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow – 226003, IN
4 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
5 Department of Orthopedics, King George Medical University, Lucknow – 226003, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 17, No 1-2 (2017), Pagination: 9-16Abstract
Osteoarthritis (OA) is considered as multifactorial disorder characterized by erosion of articular cartilage, tightening of joint space, subchondral bone remodelling and internal synovial inflammation. OA reduces joint function progressively as a person gets older. The most important group of the cytokines or chemokines are pre-dominantly involving in the early progression of the disease includes IL-1, IL-6, IL-18 and TNF-a, etc. IL-1 family of cytokines are known to be strongest stimulus for progressive synthesis of Matrix Metallo Proteinases (MMPs). Large number of immune cells, chondrocytes and endothelial cells potentially secrete IL-1 with diverse effect on number of diseases. This review highlights the association of IL-1 family cytokine in OA.Keywords
Cytokine, IL-1 Family, Mode of Action, Osteoarthritis.Full Text
- Association of Cytokine TNF-α in Development of Osteoarthritis: A Comprehensive Study
Abstract Views :241 |
PDF Views:119
Authors
Affiliations
1 Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Lucknow − 226007, IN
2 Department of Zoology, Molecular Endocrinology Lab, University of Lucknow, Lucknow − 226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow − 226003, IN
1 Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Lucknow − 226007, IN
2 Department of Zoology, Molecular Endocrinology Lab, University of Lucknow, Lucknow − 226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow − 226003, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 18, No 3-4 (2018), Pagination: 117-121Abstract
Osteo-Arthritis (OA) is a disease of joints affecting the normal functions of joint and causes physical disability. Many factors are responsible for development of osteoarthritis including over age, obesity, gender, drug abuse, over load on joints and genetic factors. OA causes health problems and impairs the quality of life with increased economic burden across the world. Apart from the pro-inflammatory role of cytokine Interleukin-1 (IL-1) in osteoarthritis, Tumor necrosis factor-alpha (TNF-α) is also involved in the progression of osteoarthritis. Members of TNF family are secreted from lymphocytes and natural killer cells but in OA patients it is also secreted from chondrocyte cells to influence the catabolic processes in Extra Cellular Matrix (ECM) by inducing the activity of matrix metaloproteinases (MMPs). In promoter region, most of the Single nucleotide polymorphisms (SNPs) of TNF-α located on -863, -857, -308, and -238. These SNPs are involved in various diseases including OA, rheumatoid Arthritis, systemic lupus erythematosus etc. Significance association of SNP -G308A of the TNF-α gene in OA has been observed in various studies. Aim of this mini review is to conclude the fundamental roles of TNF-α cytokine in patients with OA.Keywords
Cytokine, Gene Variants, Osteoarthritis, Pathophysiology, TNF-α.Full Text
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