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Therapeutic Efficacy of Natural Phytochemicals as Acetylcholinesterase Inhibitors Against Alzheimer’s Disease


Affiliations
1 Department of Bioengineering, IIRC, Integral University, Lucknow ? 226026, Uttar Pradesh, India
2 Department of Biotechnology, OPJS University, Churu - 331303, Rajasthan, India
 

Alzheimer’s Disease (AD) is a chronic degenerative brain illness marked by a slow, steady loss in cognitive function and behaviour. AD is an aging-related dementia that begins with memory loss and progresses to the destruction of brain functions as the neocortex suffers neuronal, synaptic, and dendritic connections. The formation of amyloid plaques causes the entire phenomenon to spread. Although there is presently no treatment, cholinesterase inhibitors give excellent temporary alleviation of symptoms in some individuals. The cholinergic hypothesis, which promotes cognition enhancement by regulating the production and release of acetylcholine in the brain, is now the basis for medication research and development. Acetylcholinesterase inhibitors and N-Methyl- D-Aspartate (NMDA) receptor antagonists are two drugs authorised to treat Alzheimer’s disease. Caregivers who do not have enough information on Alzheimer’s disease may feel that there is nothing they can do to manage the illness’s symptoms. This article aims to highlight the plant extract/compounds and FDA approved drugs which play the most significant role as acetylcholinesterase inhibitors in AD.


Keywords

Acetylcholine, Acetylcholine esterase, Alzheimer’s disease, Amyloid plaques, Inhibitors, Natural Compounds, Neurotransmitters.
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  • Haake A, Nguyen K, Friedman L, Chakkamparambil B, Grossberg GT. An update on the utility and safety of cholinesterase inhibitors for the treatment of Alzheimer’s disease. Expert Opin Drug Saf. 2020 Feb 1; 19(2):147-157. https://doi.org/10.1080/14740338.2020.1721456. PMid:31976781.
  • Bortolami M, Rocco D, Messore A, Di Santo R, Costi R, Madia VN, Scipione L, Pandolfi F. Acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease-a patent review (2016-present). Expert Opin Ther Pat. 2021 May 4; 31(5):399-420. https://doi.org/10.1080/13543776.2021.1874344. PMid:33428491.
  • Nordberg A, Ballard C, Bullock R, Darreh-Shori T, Somogyi M. A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer’s disease. Prim Care Companion CNS Disord. 2013 Mar 7; 15(2):26731. https://doi.org/10.4088/PCC.12r01412. PMid:23930233 PMCid:PMC3733526.
  • Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, DeLong MR. Alzheimer’s disease and senile dementia: Loss of neurons in the basal forebrain. Science. 1982 Mar 5; 215(4537):1237-1239. https://doi.org/10.1126/science.7058341. PMid:7058341.
  • Yuksel M, Tacal O. Trafficking and proteolytic processing of amyloid precursor protein and secretases in Alzheimer’s disease development: An up-to-date review. Eur J Pharmacol. 2019 Aug 5; 856:172415. https://doi.org/10.1016/j.ejphar.2019.172415. PMid:31132354.
  • Chen Y, Fu AK, Ip NY. Synaptic dysfunction in Alzheimer’s disease: Mechanisms and therapeutic strategies. Pharmacol Ther. 2019 Mar 1; 195:186-198. https://doi.org/10.1016/j.pharmthera. 2018.11.006. PMid:30439458.
  • Mroczko B, Groblewska M, Litman-Zawadzka A. The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer? s Disease (AD). Int J Mol Sci. 2019 Jan; 20(19):4661 https://doi.org/10.3390/ijms20194661. PMid:31547024 PMCid:PMC6802364.
  • Madav Y, Wairkar S, Prabhakar B. Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer’s disease. Brain Res Bull. 2019 Mar 1; 146:171-184. https://doi.org/10.1016/j.brainresbull.2019.01.004. PMid:30634016.
  • Birks JS. Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst Rev. 2006; (1). https://doi.org/10.1002/14651858.CD005593.
  • Ahmed S, Khan ST, Zargaham MK, Khan AU, Khan S, Hussain A, Uddin J, Khan A, Al-Harrasi A. Potential therapeutic natural products against Alzheimer’s disease with Reference of Acetylcholinesterase. Biomed Pharmacother. 2021 Jul 1; 139:111609. https://doi.org/10.1016/j.biopha.2021.111609. PMid:33915501.
  • Knudtson MD, Klein BE, Klein R, Shankar A. Associations with weight loss and subsequent mortality risk. Ann Epidemiol. 2005 Aug 1; 15(7):483-491. https://doi.org/10.1016/j.annepidem.2004.12.003. PMid:16029840.
  • Marucci G, Buccioni M, Dal Ben D, Lambertucci C, Volpini R, Amenta F. Efficacy of acetylcholinesterase inhibitors in Alzheimer’s disease. Neuropharmacology. 2021 Jun 1; 190:108352. https://doi.org/10.1016/j.neuropharm.2020.108352. PMid:33035532.
  • English C. Donepezil 23 mg: Is it more advantageous compared to the original? Mental Health Clinician. 2012 May; 1(11):272273. https://doi.org/10.9740/mhc.n106739.
  • Sharma K. Cholinesterase inhibitors as Alzheimer’s therapeutics. Mol Med Rep. 2019 Aug 1; 20(2):1479-1487.
  • Blanco-Silvente L, Castells X, Saez M, Barceló MA, Garre-Olmo J, Vilalta-Franch J, Capellà D. Discontinuation, efficacy, and safety of cholinesterase inhibitors for Alzheimer’s disease: A meta-analysis and meta-regression of 43 randomized clinical trials enrolling 16 106 patients. Int J Neuropsychopharmacol. 2017 Jul; 20(7):519-528. https://doi.org/10.1093/ijnp/pyx012. PMid:28201726 PMCid:PMC5492783.
  • Desai AK, Grossberg GT. Rivastigmine for Alzheimer’s disease. Expert Rev. 2005 Sep 1; 5(5):563-580. https://doi.org/10.1586/14737175.5.5.563. PMid:16162080.
  • Yang ZD, Zhang DB, Ren J, Yang MJ. Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor. Med Chem Research. 2012 Jun; 21(6):722-725. https://doi.org/10.1007/s00044-011-9581-9.
  • Mollataghi A, Coudiere E, Hadi AH, Mukhtar MR, Awang K, Litaudon M, Ata A. Anti-acetylcholinesterase, anti-?-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species. Fitoterapia. 2012 Mar 1; 83(2):298-302. https://doi.org/10.1016/j.fitote.2011.11.009. PMid:22119096.
  • Hung TM, Na M, Dat NT, Ngoc TM, Youn U, Kim HJ, Min BS, Lee J, Bae K. Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii. J Ethnopharmacol. 2008 Sep 2; 119(1):74-80. https://doi.org/10.1016/j.jep.2008.05.041. PMid:18601993.
  • Ali SK, Hamed AR, Soltan MM, Hegazy UM, Elgorashi EE, El-Garf IA, Hussein AA. In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of Alzheimer disease. BMC Complement. Altern. Med. 2013 Dec; 13(1):121. https://doi.org/10.1186/1472-6882-13-121. PMid:23721591 PMCid:PMC3701527.
  • Boonyaketgoson S, Rukachaisirikul V, Phongpaichit S, Trisuwan K. Naphthoquinones from the leaves of Rhinacanthus nasutus having acetylcholinesterase inhibitory and cytotoxic activities. Fitoterapia. 2018 Jan 1; 124:206-210. https://doi.org/10.1016/j.fitote.2017.11.011. PMid:29154868.
  • Oh MH, Houghton PJ, Whang WK, Cho JH. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine. 2004 Sep 20; 11(6):544-548. https://doi.org/10.1016/j.phymed.2004.03.001. PMid:15500267.
  • Gao E, Zhou ZQ, Zou J, Yu Y, Feng XL, Chen GD, He RR, Yao XS, Gao H. Bioactive asarone-derived phenylpropanoids from the rhizome of Acorus tatarinowii Schott. J. Nat. Prod. 2017 Nov 22; 80(11):2923-2929. https://doi.org/10.1021/acs.jnatprod.7b00457. PMid:29116780.
  • Cortes N, Sierra K, Alzate F, Osorio EH, Osorio E. Alkaloids of Amaryllidaceae as inhibitors of cholinesterases (AChEs and BChEs): An integrated bioguided study. Phytochem Anal. 2018 Mar; 29(2):217-227. https://doi.org/10.1002/pca.2736. PMid:29044771.
  • Thomsen T, Kewitz H. Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo. Life Sci. 1990 Jan 1; 46(21):1553-1558. https://doi.org/10.1016/0024-3205(90)90429U.
  • Suganthy N, Pandian SK, Devi KP. Cholinesterase inhibitory effects of Rhizophora lamarckii, Avicennia officinalis, Sesuvium portulacastrum and Suaeda monoica: Mangroves inhabiting an Indian coastal area (Vellar Estuary). J Enzyme Inhib Med Chem. 2009 Jun 1; 24(3):702-707. https://doi.org/10.1080/14756360802334719. PMid:18686140.
  • Kamal Z, Ullah F, Ayaz M, Sadiq A, Ahmad S, Zeb A, Hussain A, Imran M. Anticholinesterse and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of Atriplex laciniata L.: Potential effectiveness in Alzheimer’s and other neurological disorders. Biol Res. 2015 Dec; 48(1):11. https://doi.org/10.1186/s40659-015-0011-1. PMid:25889712 PMCid:PMC4393635.
  • Mussadiq S, Riaz N, Saleem M, Ashraf M, Ismail T, Jabbar A.New acylated flavonoid glycosides from flowers of Aerva javanica. J Asian Nat Prod Res. 2013 Jul 1; 15(7):708-716. https://doi.org/10.1080/10286020.2013.795553. PMid:23768097.
  • Ahmed E, Nawaz SA, Malik A, Choudhary MI. Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb 1; 16(3):573-580. https://doi.org/10.1016/j.bmcl.2005.10.042. PMid:16274989.
  • Orhan IE, Senol FS, Shekfeh S, Skalicka-Wozniak K, Banoglu E. Pteryxin-a promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food Chem Toxicol. 2017 Nov 1; 109:970-974. https://doi.org/10.1016/j.fct.2017.03.016. PMid:28286309.
  • Kundu A, Mitra A. Flavoring extracts of Hemidesmus indicus ischolar_mains and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities. Plant Foods Hum Nutr. 2013 Sep; 68(3):247-253. https://doi.org/10.1007/s11130-013-0363-z. PMid:23715789.
  • Cheenpracha S, Jitonnom J, Komek M, Ritthiwigrom T, Laphookhieo S. Acetylcholinesterase inhibitory activity and molecular docking study of steroidal alkaloids from Holarrhena pubescens barks. Steroids. 2016 Apr 1; 108:92-98. https://doi.org/10.1016/j.steroids.2016.01.018. PMid:26850468.
  • Fadaeinasab M, Basiri A, Kia Y, Karimian H, Ali HM, Murugaiyah V. New indole alkaloids from the bark of Rauvolfia reflexa and their cholinesterase inhibitory activity. Cell Physiol Biochem. 2015; 37(5):1997-2011. https://doi.org/10.1159/000438560. PMid:26584298.
  • Zhang XD, Liu XQ, Kim YH, Whang WK. Chemical constituents and their acetyl cholinesterase inhibitory and antioxidant activities from leaves of Acanthopanax henryi: potential complementary source against Alzheimer’s disease. Arch Pharm Res. 2014 May; 37(5):606-616. https://doi.org/10.1007/s12272-0130252-x. PMid:24085630.
  • Li S, Liu C, Liu C, Zhang Y. Extraction and in vitro screening of potential acetylcholinesterase inhibitors from the leaves of Panax japonicus. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1; 1061-1062:139-145. https://pubmed.ncbi.nlm.nih.gov/28734162/.
  • Za?uski D, Ku?niewski R. In vitro anti-AChE, anti-BuChE, and antioxidant activity of 12 extracts of Eleutherococcus species. Oxid Med Cell Longev. 2016 Jan 1; 2016. https://doi.org/10.1155/2016/4135135. PMid:27803761 PMCid:PMC5075622.
  • Jung HA, Lee EJ, Kim JS, Kang SS, Lee JH, Min BS, Choi JS. Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata. Arch Pharm Res. 2009 Oct; 32(10):1399-1408. https://doi.org/10.1007/s12272-009-2009-0. PMid:19898803.
  • Conforti F, Rigano D, Formisano C, Bruno M, Loizzo MR, Menichini F, Senatore F. Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease. J Enzyme Inhib Med Chem. 2010 Feb 1; 25(1):97-104. https://doi.org/10.3109/14756360903018260. PMid:20030514.
  • Bakthir H, Ali NA, Arnold N, Teichert A, Wessjohann L. Anticholinesterase activity of endemic plant extracts from Soqotra. Afr J Tradit Complement Altern Med. 2011; 8(3). https://doi.org/10.4314/ajtcam.v8i3.65292. PMid:22468008 PMCid:PMC3252222.
  • Chougouo RD, Nguekeu YM, Dzoyem JP, Awouafack MD, Kouamouo J, Tane P, McGaw LJ, Eloff JN. Anti-inflammatory and acetylcholinesterase activity of extract, fractions and five compounds isolated from the leaves and twigs of Artemisia annua growing in Cameroon. Springer Plus. 2016 Dec; 5(1):17. https://doi.org/10.1186/s40064-016-3199-9. PMid:27652098 PMCid:PMC5017989.
  • Peng XR, Wang X, Dong JR, Qin XJ, Li ZR, Yang H, Zhou L, Qiu MH. Rare hybrid dimers with anti-acetylcholinesterase activities from a safflower (Carthamus tinctorius L.) seed oil cake. J Agric Food Chem. 2017 Nov 1; 65(43):9453-9459. https://doi.org/10.1021/acs.jafc.7b03431. PMid:28992692.
  • Orhan IE, Gulyurdu F, KupeliAkkol E, Senol FS, ArabaciAnul S, Tatli II. Anticholinesterase, antioxidant, analgesic and antiinflammatory activity assessment of Xeranthemum annuum L. and isolation of two cyanogenic compounds. Pharm Biol. 2016 Nov 1; 54(11):2643-2651. https://doi.org/10.1080/13880209.201 6.1177092. PMid:27465673.
  • Cortes N, Posada-Duque RA, Alvarez R, Alzate F, Berkov S, Cardona-Gómez GP, Osorio E. Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: A comparative study. Life Sci. 2015 Feb 1; 122:42-50. https://doi.org/10.1016/j.lfs.2014.12.011. PMid:25529145.
  • Penumala M, Zinka RB, Shaik JB, Amooru Gangaiah D. In vitro screening of three Indian medicinal plants for their phytochemicals, anticholinesterase, antiglucosidase, antioxidant, and neuroprotective effects. Biomed Res Int. 2017 Oct 24; 2017. https://doi.org/10.1155/2017/5140506. PMid:29204442 PMCid:PMC5674485.
  • Nwidu LL, Elmorsy E, Thornton J, Wijamunige B, Wijesekara A, Tarbox R, Warren A, Carter WG. Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea. Pharm Biol. 2017 Jan 1; 55(1):1875-1883. https://doi.org/10.1080/13880209.2017.1339283. PMid:28629287 PMCid:PMC6130458.
  • Kuk EB, Jo AR, Oh SI, Sohn HS, Seong SH, Roy A, Choi JS, Jung HA. Anti-Alzheimer’s disease activity of compounds from the ischolar_main bark of Morus alba L. Arch Pharm Res. 2017 Mar; 40(3):338-349. https://doi.org/10.1007/s12272-017-0891-4. PMid:28093699.
  • Tung BT, Hai NT, Thu DK. Antioxidant and acetylcholinesterase inhibitory activities in vitro of different fraction of Huperzia squarrosa (Forst.) Trevis extract and attenuation of scopolamineinduced cognitive impairment in mice. J Ethnopharmacol. 2017 Feb 23; 198:24-32. https://doi.org/10.1016/j.jep.2016.12.037.
  • PMid:28025162.
  • Armijos C, Gilardoni G, Amay L, Lozano A, Bracco F, Ramirez J, Bec N, Larroque C, Finzi PV, Vidari G. Phytochemical and ethnomedicinal study of Huperzia species used in the traditional medicine of Saraguros in Southern Ecuador; AChE and MAO inhibitory activity. J Ethnopharmacol. 2016 Dec 4; 193:546-554.
  • https://doi.org/10.1016/j.jep.2016.09.049. PMid:27686269.
  • Adewusi EA, Steenkamp V. In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa. Asian Pac J Trop Med. 2011 Oct 1; 4(10):829-835. https://doi.org/10.1016/S1995-7645(11)60203-4.
  • Cardoso-Lopes EM, Maier JA, Silva MR, Regasini LO, Simote SY, Lopes NP, Pirani JR, Bolzani VD, Young MC. Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease. Molecules. 2010 Dec; 15(12):9205-9213. https://doi.org/10.3390/molecules15129205.
  • PMid:21160449 PMCid:PMC6259197.
  • Yang ZD, Zhang X, Du J, Ma ZJ, Guo F, Li S, Yao XJ. An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations. Nat Prod Res. 2012 Mar 1; 26(5):387-392. https:// doi.org/10.1080/14786419.2010.487188. PMid:21732870.
  • Ingkaninan K, Temkitthawon P, Chuenchom K, Yuyaem T, Thongnoi W. Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J Ethnopharmacol. 2003 Dec 1; 89(2-3):261-264. https://doi.org/10.1016/j.jep.2003.08.008. PMid:14611889.
  • Pereira DM, Ferreres F, Oliveira JM, Gaspar L, Faria J, Valentão P, Sottomayor M, Andrade PB. Pharmacological effects of Catharanthus roseus ischolar_main alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul 1; 17(8-9):646-652. https://doi.org/10.1016/j.phymed.2009.10.008. PMid:19962870.
  • Mukherjee PK, Mukherjee D, Maji AK, Rai S, Heinrich M. The sacred lotus (Nelumbo nucifera)-phytochemical and therapeutic profile. Journal of Pharmacy and Pharmacology. 2009 Apr; 61(4):407-422. https://doi.org/10.1211/jpp.61.04.0001.
  • Berkov S, Codina C, Viladomat F, Bastida J. N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum. Bioorg Med Chem Lett. 2008 Apr 1; 18(7):2263-2266. https://doi.org/10.1016/j.bmcl.2008.03.008. PMid:18356045.
  • Ahmed T, Gilani AH. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer’s disease. Pharmacol Biochem Behav. 2009 Feb 1; 91(4):554-559. https://doi.org/10.1016/j.pbb.2008.09.010. PMid:18930076.
  • Adefegha SA, Oboh G. Acetylcholinesterase (AChE) inhibitory activity, antioxidant properties and phenolic composition of two Aframomum species. J Basic Clin Physiol Pharmacol. 2012 Nov 1; 23(4):153-161. https://doi.org/10.1515/jbcpp-2012-0029. PMid:23023693.
  • Rahman AU, Khalid A, Sultana N, Nabeel Ghayur M, Ahmed Mesaik M, Riaz Khan M, Gilani AH, Iqbal Choudhary M. New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids. J Enzyme Inhib Med Chem. 2006 Jan 1; 21(6):703-710. https://doi.org/10.1080/14756360600889708.
  • PMid:17252943.
  • Kucukboyac? N, Orhan I, ?ener B, Nawaz SA, Choudhary MI. Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L. Z Naturforsch C J Biosci. 2010 Apr 1; 65(3-4):187-194. https://doi.org/10.1515/znc-2010-3-404. PMid:20469636.
  • Ahmad H, Ahmad S, Khan E, Shahzad A, Ali M, Tahir MN, Shaheen F, Ahmad M. Isolation, crystal structure determination and cholinesterase inhibitory potential of isotalatizidine hydrate from Delphinium denudatum. Pharm Biol. 2017 Jan 1; 55(1):680-686. https://doi.org/10.1080/13880209.2016.1240207.
  • PMid:28033733 PMCid:PMC6130761.
  • Kaufmann D, Kaur Dogra A, Tahrani A, Herrmann F, Wink M. Extracts from traditional Chinese medicinal plants inhibit acetylcholinesterase, a known Alzheimer’s disease target. Molecules. 2016 Sep; 21(9):1161. https://doi.org/10.3390/molecules21091161. PMid:27589716 PMCid:PMC6273583.
  • Mogana R, Adhikari A, Debnath S, Hazra S, Hazra B, Teng-Jin K, Wiart C. The antiacetylcholinesterase and antileishmanial activities of Canarium patentinervium Miq. Bio Med Res Int. 2014 May 15; 2014. https://doi.org/10.1155/2014/903529. PMid:24949478 PMCid:PMC4053261.
  • Geromichalos GD, Lamari FN, Papandreou MA, Trafalis DT, Margarity M, Papageorgiou A, Sinakos Z. Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. J Agric Food Chem. 2012 Jun 20; 60(24):6131-6138. https://doi.org/10.1021/jf300589c. PMid:22655699.
  • Ullah F, Ayaz M, Sadiq A, Hussain A, Ahmad S, Imran M, Zeb A. Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var; florentina. Nat Prod Res. 2016
  • Jun 17; 30(12):1440-1444. https://doi.org/10.1080/14786419.201 5.1057585. PMid:26166432.
  • Zhan ZJ, Yu Q, Wang ZL, Shan WG. Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities. Bioorg Med Chem Lett. 2010 Nov 1; 20(21):6185-6187.
  • https://doi.org/10.1016/j.bmcl.2010.08.123. PMid:20850311.
  • Yang ZD, Duan DZ, Du J, Yang MJ, Li S, Yao XJ. Geissoschizine methyl ether, a corynanthean-type indole alkaloid from Uncaria rhynchophylla as a potential acetylcholinesterase inhibitor. Nat Prod Res. 2012 Jan 1; 26(1):22-28. https://doi.org/10.1080/1478 6419.2010.529811. PMid:21714741.
  • Seidl C, Correia BL, Stinghen AE, Santos CA. Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius. Z Naturforsch C J Biosci. 2010 Aug 1; 65(7-8):440-444. https://doi.org/10.1515/znc-2010-7-804. PMid:20737911.
  • Andrade JP, Berkov S, Viladomat F, Codina C, Zuanazzi JA, Bastida J. Alkaloids from Hippeastrum papilio. Molecules. 2011 Aug; 16(8):7097-7104. https://doi.org/10.3390/molecules16087097. PMid:21852767 PMCid:PMC6264239.
  • van Rijn RM, Rhee IK, Verpoorte R. Isolation of acetylcholinesterase inhibitory alkaloids from Nerine bowdenii. Nat Prod Res. 2010 Feb 15; 24(3):222-225. https://doi.org/10.1080/14786410802263758. PMid:20140801.
  • Arruda M, Viana H, Rainha N, Neng NR, Rosa JS, Nogueira JM, Barreto MD. Anti-acetylcholinesterase and antioxidant activity of essential oils from Hedychium gardnerianum Sheppard ex Ker-Gawl. Molecules. 2012 Mar; 17(3):3082-3092. https://doi.org/10.3390/molecules17033082. PMid:22410418
  • PMCid:PMC6268484.
  • Cho JK, Ryu YB, Curtis-Long MJ, Ryu HW, Yuk HJ, Kim DW, Kim HJ, Lee WS, Park KH. Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits. Bioorg. Med. Chem. 2012 Apr 15; 20(8):2595-2602. https://doi.org/10.1016/j.bmc.2012.02.044. PMid:22445674.
  • Sarikaya BB, Kaya GI, Onur MA, Viladomat F, Codina C, Bastida J, Somer NU. Alkaloids from Galanthus rizehensis. Phytochem. Lett. 2012 Jun 1; 5(2):367-370. https://doi.org/10.1016/j.phytol.2012.03.004.
  • Petrovi? GM, Stamenkovi? JG, Kostevski IR, Stojanovi? GS, Miti? VD, Zlatkovi? BK. Chemical composition of volatiles; antimicrobial, antioxidant and cholinesterase inhibitory activity of Chaerophyllum aromaticum L.(Apiaceae) essential oils and extracts. Chem. Biodivers. 2017 May; 14(5):e1600367. https://doi.org/10.1002/cbdv.201600367. PMid:28273389.

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  • Therapeutic Efficacy of Natural Phytochemicals as Acetylcholinesterase Inhibitors Against Alzheimer’s Disease

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Authors

Adnan Ahmad
Department of Bioengineering, IIRC, Integral University, Lucknow ? 226026, Uttar Pradesh, India
Krishan Pal
Department of Biotechnology, OPJS University, Churu - 331303, Rajasthan, India

Abstract


Alzheimer’s Disease (AD) is a chronic degenerative brain illness marked by a slow, steady loss in cognitive function and behaviour. AD is an aging-related dementia that begins with memory loss and progresses to the destruction of brain functions as the neocortex suffers neuronal, synaptic, and dendritic connections. The formation of amyloid plaques causes the entire phenomenon to spread. Although there is presently no treatment, cholinesterase inhibitors give excellent temporary alleviation of symptoms in some individuals. The cholinergic hypothesis, which promotes cognition enhancement by regulating the production and release of acetylcholine in the brain, is now the basis for medication research and development. Acetylcholinesterase inhibitors and N-Methyl- D-Aspartate (NMDA) receptor antagonists are two drugs authorised to treat Alzheimer’s disease. Caregivers who do not have enough information on Alzheimer’s disease may feel that there is nothing they can do to manage the illness’s symptoms. This article aims to highlight the plant extract/compounds and FDA approved drugs which play the most significant role as acetylcholinesterase inhibitors in AD.


Keywords


Acetylcholine, Acetylcholine esterase, Alzheimer’s disease, Amyloid plaques, Inhibitors, Natural Compounds, Neurotransmitters.

References





DOI: https://doi.org/10.18311/jeoh%2F2022%2F29511