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Therapeutic Efficacy of Natural Phytochemicals as Acetylcholinesterase Inhibitors Against Alzheimer’s Disease


Affiliations
1 Department of Bioengineering, IIRC, Integral University, Lucknow ? 226026, Uttar Pradesh, India
2 Department of Biotechnology, OPJS University, Churu - 331303, Rajasthan, India
 

Alzheimer’s Disease (AD) is a chronic degenerative brain illness marked by a slow, steady loss in cognitive function and behaviour. AD is an aging-related dementia that begins with memory loss and progresses to the destruction of brain functions as the neocortex suffers neuronal, synaptic, and dendritic connections. The formation of amyloid plaques causes the entire phenomenon to spread. Although there is presently no treatment, cholinesterase inhibitors give excellent temporary alleviation of symptoms in some individuals. The cholinergic hypothesis, which promotes cognition enhancement by regulating the production and release of acetylcholine in the brain, is now the basis for medication research and development. Acetylcholinesterase inhibitors and N-Methyl- D-Aspartate (NMDA) receptor antagonists are two drugs authorised to treat Alzheimer’s disease. Caregivers who do not have enough information on Alzheimer’s disease may feel that there is nothing they can do to manage the illness’s symptoms. This article aims to highlight the plant extract/compounds and FDA approved drugs which play the most significant role as acetylcholinesterase inhibitors in AD.


Keywords

Acetylcholine, Acetylcholine esterase, Alzheimer’s disease, Amyloid plaques, Inhibitors, Natural Compounds, Neurotransmitters.
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  • Therapeutic Efficacy of Natural Phytochemicals as Acetylcholinesterase Inhibitors Against Alzheimer’s Disease

Abstract Views: 275  |  PDF Views: 136

Authors

Adnan Ahmad
Department of Bioengineering, IIRC, Integral University, Lucknow ? 226026, Uttar Pradesh, India
Krishan Pal
Department of Biotechnology, OPJS University, Churu - 331303, Rajasthan, India

Abstract


Alzheimer’s Disease (AD) is a chronic degenerative brain illness marked by a slow, steady loss in cognitive function and behaviour. AD is an aging-related dementia that begins with memory loss and progresses to the destruction of brain functions as the neocortex suffers neuronal, synaptic, and dendritic connections. The formation of amyloid plaques causes the entire phenomenon to spread. Although there is presently no treatment, cholinesterase inhibitors give excellent temporary alleviation of symptoms in some individuals. The cholinergic hypothesis, which promotes cognition enhancement by regulating the production and release of acetylcholine in the brain, is now the basis for medication research and development. Acetylcholinesterase inhibitors and N-Methyl- D-Aspartate (NMDA) receptor antagonists are two drugs authorised to treat Alzheimer’s disease. Caregivers who do not have enough information on Alzheimer’s disease may feel that there is nothing they can do to manage the illness’s symptoms. This article aims to highlight the plant extract/compounds and FDA approved drugs which play the most significant role as acetylcholinesterase inhibitors in AD.


Keywords


Acetylcholine, Acetylcholine esterase, Alzheimer’s disease, Amyloid plaques, Inhibitors, Natural Compounds, Neurotransmitters.

References





DOI: https://doi.org/10.18311/jeoh%2F2022%2F29511