Journal of Health Science Research

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Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus


Affiliations
1 Diacon Hospital Bangalore, 19th main road, 1st block, Rajajinagar, Bangalore - 560010, Karnataka, India
2 Department of Biochemistry, International Medical School, Management and Science University University Drive, Off Persiaran Olahraga, Sekysen 13, Shah Alam - 40100, Selangor, Darul Ehsan, Malaysia
3 Department of Biochemistry, A J Institute of Medical Sciences, Kuntinana, Mangalore - 575004, Karnataka, India
4 Department of Otolaryngology, International Medical School, Management and Science University University Drive, Off Persiaran Olahraga, Sekysen 13, Shah Alam - 40100, Selangor, Darul Ehsan, Malaysia
 

Aim: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus. Materials and Method: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose. Result: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol). Conclusion: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.

Keywords

Adenosine Deaminase, Diabetes Mellitus Type 2, Glycated Haemoglobin.
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  • Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus

Abstract Views: 278  |  PDF Views: 97

Authors

Shashikala Magadi Dasegowda
Diacon Hospital Bangalore, 19th main road, 1st block, Rajajinagar, Bangalore - 560010, Karnataka, India
Ashok Kumar Jeppu
Department of Biochemistry, International Medical School, Management and Science University University Drive, Off Persiaran Olahraga, Sekysen 13, Shah Alam - 40100, Selangor, Darul Ehsan, Malaysia
Sushith
Department of Biochemistry, A J Institute of Medical Sciences, Kuntinana, Mangalore - 575004, Karnataka, India
Kavitha Ashok Kumar
Department of Otolaryngology, International Medical School, Management and Science University University Drive, Off Persiaran Olahraga, Sekysen 13, Shah Alam - 40100, Selangor, Darul Ehsan, Malaysia

Abstract


Aim: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus. Materials and Method: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose. Result: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol). Conclusion: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.

Keywords


Adenosine Deaminase, Diabetes Mellitus Type 2, Glycated Haemoglobin.



DOI: https://doi.org/10.18311/jhsr%2F2016%2F113870