Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Rai, S.
- Adaptive Significance of Annual Variation in Immune Parameters and Endogenous Hormones (Melatonin and Thyroxine) of a Tropical Rodent Funambulus pennanti
Abstract Views :320 |
PDF Views:1
Authors
Affiliations
1 Pineal Research Lab, Reproductive Biology Unit, Department of Zoology, Banaras Hindu University, Varanasi- 221 005, IN
1 Pineal Research Lab, Reproductive Biology Unit, Department of Zoology, Banaras Hindu University, Varanasi- 221 005, IN
Source
Journal of Endocrinology and Reproduction, Vol 10, No 2 (2006), Pagination: 111-116Abstract
The significance of annual variation in metabolic (thyroxine) and chronobiotic (melatonin) hormones in relation to immune adaptation of the Indian palm squirrel was investigated. The squirrel is summer breeder and, hence, remains healthy during reproductively active phase (Feb - Aug) when melatonin level is low and thyroxine level is high. Our data show that the circulating levels of melatonin (MEL) and thyroxine (T4) have their respective annual rhythms, which are inversely related. Thyroxine level is low during the winter months (Sep-Jan) when metabolic activity of this rodent is also low. During this period melatonin level is high because of the short photoperiod and the squirrels indicate poor reproductive activity, with low gonadal steroids, which could be due to high circulating melatonin. The immune parameters also present an annual rhythmicity, which is parallel with circulating melatonin level, but inversely related to thyroxine level. This suggests that the metabolic hormone, thyroxine, and the chronobiotic hormone, melatonin, might be responsible for maintenance of the immune system to adapt the rodent for the rigors of the seasonal environmental changes.Keywords
Annual Variation, Immune Parameters, Melatonin, Squirrel, Thyroxine.- In Vitro Effect of Malatonin and IL-1 (Produced by Peritoneal Macrophages) on Spleenic and Thymic Lymphocyte Proliferation of Funambulus pennanti (Indian Palm Squirrel)
Abstract Views :309 |
PDF Views:0
Authors
Affiliations
1 Pineal research Lab, Reproductive Biology Unit, Department of Zoology, BHU, Varanasi-221 005, IN
1 Pineal research Lab, Reproductive Biology Unit, Department of Zoology, BHU, Varanasi-221 005, IN
Source
Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 65-65Abstract
The immune system was believed until recently, to be closely integrated with other physiological circuits such as the central nervous and neuroendocrine system of which pineal is a integral constituent (Gupta 1990). A lot of in vivo and in vitro studies have been performed to explain the immunoregulatory role of melatonin but till date there is very less report, available in the laboratory animals in this context. The present study was undertaken to elucidate the immunoregulatory role of pineal melatonin together with IL-1, i.e. synergic effect (IL-1 produced by LPS induced peritoneal macrophages) on the spleenocyte and thymocyte proliferation of the spleen and thymus respectively of F. pennanti. IL-1 is well known to induce proliferation of lymphocytes in rodents (Durum et ai, 1985; Mannel et al., 1985). This capacity of IL-1 has been utilized in its wisely used bioassay (Gearing et al., 1985).- Trade-Off Relationship between Melatonin and Gonadal Steroid on Melatonin Receptor (MEL 1A R) Expression in Lymphoid Tissue
Abstract Views :177 |
PDF Views:0
Authors
Affiliations
1 Pineal Research Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, IN
1 Pineal Research Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, IN