Journal of Endocrinology and Reproduction

P. Venkataraman ¹, M. Sridhar ¹, S. Dhanammal ¹, P. Murugesan ¹, J. Arunakaran ¹, N. Srinivasan ¹, M. M. Aruldhas ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, IN

Abstract

Effects of quercetin, vitamin C and E on PCB exposed ventral prostaitc zinc content were studied in adult albino rats, a group of 20 rats were treated with Aroclor 1254 (2 mg/kg bwt/day/IP) for 30 days. Five rats were treated as PCB control. The remaining 15 rats were subdivided into the following subgroups of five animals each. They were given vitamin C (500 mg/kgbwt/day/oral) for 10 days; vitamin E (50 mg/kg bwt/day/oral) for 10 days; quercetin (2 mg/kg bwt/day/oral) for 10 days.

Full Text

     

P. Murugesan ¹, J. Senthilkumar ¹, K. Balasubramanian ¹, M. M. Aruldhas ¹, P. Govindarajulu ¹, J. Arunakaran ¹

Affiliations
1 Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, IN

Abstract

To find out the effect of polychlorinated biphenyl compound Aroclor 1254 on rat Leydig cellular antioxiSant system, adult male rats were exposed to Aroclor 1254 (2 mg/kg b.wt.) mixed with com oil through intraperitoneal (ip) injection daily for 30 days. The control rats were administered com oil as vehicle. Testes were removed on the both groups and Leydig cells were isolated by enzymatic digestion and purified on discontinous percoll gradient.

Full Text