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Kanagaraj, P.
- Anticancer Activity of Quercetin on Prostate Cancer Cell Line In vitro
Abstract Views :195 |
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Authors
M. R. Vijayababu
1,
P. Kanagaraj
1,
A. Arunkumar
1,
Siva Dhanammal
1,
K. Balasubramanian
1,
N. Srinivasan
1,
M. M. Aruldhas
1,
J. Arunakaran
1
Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN
Source
Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 47-47Abstract
Recent estimates have placed prostate cancer as the most commonly diagnosed malignancy. It is the fourth most common cancer in men worldwide. Androgen dependent prostate cancer can responds to androgen ablative therapy. However, if the cell contains heterogeneous population of both androgen dependent and androgen independent, the androgen ablative therapy can only responds to androgen dependent cell population but not to independent cancer.- Effect of 17β-Estradiol (E2) on the Production of Insulin Like Growth Factor-I (IGF-I) and their Components on PC-3 Cell Lines
Abstract Views :212 |
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Authors
P. Kanagaraj
1,
M. R. Vijayababu
1,
S. Sitta-Djody
1,
N. Srinivasan
1,
M. M. Aruldhas
1,
P. Govindarajulu
1,
J. Arunakaran
1
Affiliations
1 Department of Endocrinology, Dr. ALMPGIBMS, University of Madras, Taramani, Chennai - 600 113, IN
1 Department of Endocrinology, Dr. ALMPGIBMS, University of Madras, Taramani, Chennai - 600 113, IN
Source
Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 56-56Abstract
Insulin like growth factors have been implicated in the regulation of prostate epithelial cell proliferation and induction of prostate cancer. Estrogens play an important role in prostate physiology and disease development. E2 has been reported to regulate the production of IGFs and IGFBPs in prostate cell lines. Hence, it is attempted to study the effects of E2 on the production of IGFs and IGFBPs in PC-3 cell line. The PC-3 cells (1x105 cells/ well) were treated with different doses of E2 (1,10 and 10 nM) for 24 hrs and 48 hrs, the conditioned media were collected and assayed for IGF-I and IGFBP-5. Dose and duration dependent effect of E2 on IGF-I and IGFBP-5 on PC-3 eel lines will be discussed with available literature.- Effect of Diallyl Disulfide on Drug Metabolizing Enzymes against Aroclor-1254 Toxicity on Rat Primary Prostate Epithelial Cells
Abstract Views :190 |
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Authors
A. Arunkumar
1,
P. Kanagaraj
1,
M. R. Vijayababu
1,
K. Balsubramanian
1,
M. M. Aruldhas
1,
J. Arunakaran
1
Affiliations
1 Department of Endocrinology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-600 113, IN
1 Department of Endocrinology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-600 113, IN
Source
Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 67-68Abstract
The cytochrome P450s are hemoproteins, which play critical role in the bioactivation and detoxicfication of a majority of xenobiotic substances such as drugs, environmental pollutants and dietary chemicals, and endogenous compounds such as steroids, fatty acids and prostaglandins. Environmental pollutants are main cause of several carcinogenesis, among these, polychlorinated biphenyls (PCB), are persistant environmental contaminants. Numerous epidemiological and experimental studies imply that garlic can be considered as a dietary anticarcinogenic component.- Effect of Lycopene on IGF-I, IGF Binding Protein-3 and IGF Type-I Receptor in Prostate Cancer Cells
Abstract Views :228 |
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Authors
P. Kanagaraj
1,
M. R. Vijayababu
1,
B. Ravisankar
1,
J. Anbalagan
1,
M. M. Aruldhas
1,
J. Arunakaran
1
Affiliations
1 Department of Endocrinology, Dr ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, IN
1 Department of Endocrinology, Dr ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, IN