Journal of Endocrinology and Reproduction

D. D. Jhala ¹, N. J. Chinoy ¹, S. B. Nair ¹

Affiliations
1 Reproductive Endocrinology and Toxicology Unit, DST-FIST Sponsored Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380 009, IN

Abstract

Studies on benefical effects of some antioxidant Vitamins (C and E) and Calcium phosphate supplementation to mice for recovery in ovarian steroidogenesis after sodium fluoride (NaF 5 mg/kg body weight) and arsenic trioxide (As₂O₃ 0.5 mg/kg body weight) treatment were undertaken. The doses of toxicants were based on their LD₅₀ value while those of the vitamms and calcium on previous work. All the biochemical parameters (protein, cholesterol, 3β and 17β HSD) were studied using standard methods.

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S. B. Nair ¹, D. D. Jhala ¹, N. J. Chinoy ¹

Affiliations
1 Cell Biology, Cytogenetics and Toxicology Unit, DST-FIST Sponsored Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380009, IN

Abstract

Trace elements like fluoride and arsenic are known to exert their toxic effects if their intake exceeds normal levels. The present in vitro studies on genotoxicity of fluoride and arsenic at dosages of 10μg and 0.001μg/7ml of culture media respectively were carried out to determine their effects on acrocentric and telomeric associations in human lymphocyte cultures.

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