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Thomas, Tinku
- Pattern of Amino Acid Oxidation in Low BMI South Indian Pregnant Women
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Authors
Affiliations
1 Division of Nutrition, Department of Physiology, St. John’s Research Institute, Bangalore - 560 034, IN
2 Division of Epidemiology and Biostatistics, St. John’s Research Institute, Bangalore - 560 034, IN
1 Division of Nutrition, Department of Physiology, St. John’s Research Institute, Bangalore - 560 034, IN
2 Division of Epidemiology and Biostatistics, St. John’s Research Institute, Bangalore - 560 034, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 53, No 2 (2016), Pagination: 153-163Abstract
It is not known whether Indian pregnant women with low Body Mass Index (BMI) have adequate protein stores to provide sufficient amino acids for the growing fetus and how this interacts with the maternal body fat (energy) stores in early pregnancy. This study aimed to measure amino acid oxidation in pregnant women with low BMI and to evaluate the influence of maternal body fat on amino acid oxidation in early pregnancy. In two experimental studies of low BMI women, leucine oxidation rates significantly reduced from 1st to 3rd trimester (post absorptive state, p<0.002 and fed state, p<0.003, Wilcoxon sign rank test). In the post absorptive state in the 1st trimester, leucine oxidation negatively correlated with maternal fat percentage (r=-0.32, p=0.04). Hence, it would appear that the availability of body fat as an energy store in early pregnancy could reduce the utilization of amino acid as a substrate for the energy demands of the growing feto-placental unit.Keywords
Pregnancy, Low Body Mass Index, Protein Synthesis, Amino Acid Oxidation, 1st Trimester, Maternal Fat Percentage.References
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- Dwarkanath, P., Hsu, J.W., Tang, G.J., Anand, P., Thomas, T., Thomas, A., Sheela, C.N., Kurpad, A.V. and Jahoor, F. Effect of energy and protein supplementation on amino acid kinetics and pregnancy outcomes in underweight Indian women. J. Nutr., 2016, (E pub ahead of print).
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- Effect of Increased Dietary Protein on the Plasma Methyl-Cycle Amino Acid Profile and Kinetics during Pregnancy
Abstract Views :268 |
PDF Views:1
Authors
Sarita Devi
1,
Tinku Thomas
2,
Pratibha Dwarkanath
1,
Annamma Thomas
3,
C. N. Sheela
3,
Arpita Mukhopadhyay
1,
Anura V. Kurpad
1
Affiliations
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Department of Obstetrics and Gynaecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Department of Obstetrics and Gynaecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 53, No 4 (2016), Pagination: 380-390Abstract
Low intakes of quality dietary protein could affect the methionine cycle during pregnancy, which is important for fetal growth and epigenetic regulations. Since low quality protein intake is prevalent in India, it is important to define biomarkers of the low protein intake, specifically of methyl cycle homeostasis. A secondary analysis of data was performed, from a randomized intervention trial with 500 ml milk/d on south Indian pregnant women, to examine the association of dietary protein intake with concentrations of specific amino acids (methionine, glycine and serine). The subjects also underwent isotopic infusions (n = 52) for the measurement of amino acid kinetics. Dietary intakes were measured each week by multiple 24 h recall until delivery. The plasma concentrations of amino acids (methionine, serine and glycine) were compared with kinetics of methionine i.e. transmethylation, remethylation and transulfuration (TM, RM, TS) and serine to glycine conversion rates, as measured by stable isotope labeled amino acid infusion. Dietary protein intake in the 3rd trimester correlated positively with intakes of milk and milk based food products (ρ=0.52, p<0.001) and methionine (ρ=0.97, p<0.001) and with gestational weight gain (GWG, ρ=0.32, p=0.044). While the methionine concentration did not correlate with methyl cycle flux parameters (TM, RM and TS), the plasma concentrations of conditionally essential serine and glycine were positively correlated with their respective flux rate and with RM, TM and TS rates. Further, glycine concentrations specifically correlated positively with serine to glycine conversion rates (ρ=0.32, p=0.027). Dietary protein and methionine supply are important for the conservation of methionine during pregnancy. This had an effect on GWG, but not on birth weight, though this may have been due to the relatively small sample size. The plasma concentration of glycine was correlated with the serine-glycine conversion, which affords methyl groups for the body and supplies these when dietary protein/methionine is in poor supply. This indicates that itcan act as a biomarker of the serine-glycine conversion flux rate, which increases in the presence of a poor protein supply. In general, the plasma concentrations of these conditionally essential amino acids may be biomarkers of the methyl cycle during pregnancy, but this needs to be tested in a larger sample.Keywords
Amino Acid Kinetics, Maternal Protein Intake, Glycine, Serine, Methionine Cycle, Pregnancy.References
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- Maternal Methyl-Cycle Amino Acid Profile and Kinetics:Relation with Placental Growth
Abstract Views :242 |
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Authors
Sarita Devi
1,
Julian Crasta
2,
Tinku Thomas
3,
Pratibha Dwarkanath
1,
Annamma Thomas
4,
C. N. Sheela
4,
Anura V. Kurpad
1,
Arpita Mukhopadhyay
1
Affiliations
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Department of Pathology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
4 Department of Obstetrics and Gynecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Department of Pathology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
4 Department of Obstetrics and Gynecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 54, No 2 (2017), Pagination: 118-126Abstract
Maternal intake of quality protein regulates placental development and function thereby affecting fetal growth. Considering the prevalence of inadequate intakes of quality protein in Indian pregnant women, understanding the interplay between maternal supply of protein, its metabolism and fetoplacental growth becomes important. A secondary analysis of data from an open labelled-randomized intervention trial with 500 ml milk/day on south Indian pregnant women with marginally low vitamin B12 status, was performed to assess the relations between placental parameters and maternal trimester 3 methyl-cycle amino acid status as well as kinetics. This analysis was performed for 42 pregnancies from the trial where placentae had been collected and placental parameters had been measured. For these pregnancies, data on trimester 3 methionine, serine and glycine kinetics as well as plasma free amino acid concentrations were available. Protein intake and plasma citrulline concentrations were positively correlated at trimester 3 (ρ = 0.34, P = 0.027). Placental weight correlated positively with methyl-cycle specific amino acid concentrations [methionine (ρ = 0.32, P = 0.0388), serine (ρ = 0.49, P = 0.0009)], methionine kinetics [total methionine flux rates (ρ = 0.42, P = 0.006), RM (ρ = 0.45, P = 0.003), TS (ρ = 0.32, P = 0.046), TM (ρ = 0.45, P = 0.004)] and with birth weight (ρ = 0.57, P < 0.001). Findings from the current study indicate that maternal amino acid availability and more importantly, maternal methionine kinetics, positively influenced placental growth, likely mediated by key amino acids such as citrulline, which is known to regulate placental blood flow and function. As an appropriately functioning placenta is indispensable for fetal growth, these findings will form the basis for detailed mechanistic explorations into the placental regulation of maternal supply of amino acid to the fetus for designing effective intervention strategies towards optimizing fetomaternal health during and after pregnancy.Keywords
Vitamin B12, Pregnancy, Glycine, Methionine, Serine, Methionine Kinetic, Amino Acids.References
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- Effect of a Single Session of Acute Aerobic Exercise on the Activities of High Density Lipoprotein Enzymes
Abstract Views :237 |
PDF Views:1
Authors
Affiliations
1 Division of Nutrition, St John’s Research Institute, Bangalore, IN
2 Department of Biochemistry, St. John’s Medical College and Hospital, Bangalore, IN
1 Division of Nutrition, St John’s Research Institute, Bangalore, IN
2 Department of Biochemistry, St. John’s Medical College and Hospital, Bangalore, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 55, No 1 (2018), Pagination: 18-28Abstract
High Density Lipoprotein (HDL) is considered to be an anti-atherogenic molecule and its beneficial function is driven by a number of enzymes such as LCAT (Lecithin Cholesterol Acyl Transferase), PON1 (Paraoxonase 1), PAF-AH (Platelet-Activating Factor Acetyl Hydrolase) and CETP (Cholesteryl Ester Transfer Protein). Low HDL-C level is the most prevalent dyslipidemia seen in India and exercise is one reliable way to improve its levels. While acute exercise is known to increase HDL-C levels, not much is known about its effects on HDL functions. This study was aimed at assessing the effect of a single bout of acute aerobic exercise on key HDL functions. Ten healthy adult male volunteers (20-35 years) were made to exercise at 65-80% VO2 max to expend 200 Kcal using a modified Bruce protocol. Plasma samples were collected at different time points (before exercise, 15 min, 1 hour, 2 hours, 4 hours, 24 hours, 48 hours post-exercise) for analysis of HDL anti-inflammatory function and its related enzyme activities. Friedman ANOVA followed by post-hoc Wilcoxon matched pair test, showed that PON1 activity increased immediately but reached significance 48 hours post-exercise (Z=-2.666, p=0.008). CETP and LCAT activities were decreased significantly at the 4th hour post-exercise and continued to be low even up to 48 hours (Z=-2.666, p=0.008), whereas HDL-C levels, MPO activity and HDL-II did not vary significantly at different time points. Enhanced activity of the antioxidant enzyme PON1, in combination with decreased activities of pro-atherogenic enzymes CETP and LCAT suggest that even a single bout of acute exercise could be effective in eliciting athero-protective changes in HDL function independent of HDL-C levels.Keywords
Acute Exercise, Antioxidant Enzymes, CETP, HDL-C, PON1.References
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