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Baskaran, Nandhini
- Molecular Docking and Therapeutic Targets of Flavanol Compounds from Camellia Sinensis on Alzheimer’s Disease
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Authors
Affiliations
1 Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, IN
1 Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 59, No 2 (2022), Pagination: 152-158Abstract
Alzheimer’s disease is a progressive neurodegenerative disorder with neuropsychiatric symptoms and several cognitive functions and is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine. The current study is performed to investigate possible interaction of the active components identified from Camellia sinensis (Green tea) with acetyl cholinesterase (AChE) through docking studies using Schrödinger software (Maestro V: 11.8 Schrödinger_suite-2019). In silico study results clearly showed that catechin and epicatechin-3-gallate binds effectively with AChE through strong hydrogen bonding.Keywords
Alzheimer’s Disease, Acetylcholinesterase, Catechin, Epicatechin-3-gallate, Docking, Camellia Sinensis
References
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