Sajjad R. Chughtai ¹, K. Naseem ¹, A. S. Mohmand ¹

Affiliations
1 National Agricultural Research Centre, Islamabad, IN

Abstract

Human population is widely exposed to an increasing number of natural and manmade environmental chemicals which are believed to be responsible for most human cancers. The establishment of a strong correlation between the carcinogenic and mutagenic potential of most chemicals opened by the possibility of large scale screening of chemicals for mutagenicity in short-term tests.

Full Text

     

S. R. Chughtai ¹, A. S. Mohmand ¹, K. Naseem ¹

Affiliations
1 Department of Biology, Quaid-i-Azam University, Islamabad, PK

Abstract

Mankind is exposed to a large number of chemicals many of which are mutagens and/or carcinogens. The occurrence of a strong correlation between carcinogenicity and mutagenicity of many of those chemicals lead to extensive screening in short term tests for mutagenicity. However, these tests have primarily focussed on industrial and agricultural chemicals. The naturally occurring compounds to which human population is widely exposed have not been tested extensively. An important group of natural compounds is ingested as a part of the human diet. A relationship between diet and certain cancers is known, and many plant products were mutagenic. Thus, there is a great need to test dietary components for their possible mutagenicity and/or carcinogenicity.

Full Text

     

S. R. Chughtai ¹, K. Naseem ¹, S. Butool ¹

Affiliations
1 Department of Botany, University of Baluchistan, Quetta, PK

Abstract

Most of the human cancers are believed to be due to exposure to environmental chemicals. Since most of the environmental carcinogens are also mutagens, they can be detected in short-term tests for mutagenicity. These types of test systems have been widely used to assess the genotoxicity of industrial and agricultural chemicals. Recently, there has been increasing concern about the mutagenic and/or carcinogenic potential of the chemicals in our food products. A relationstiip between diet and certain cancers is known, and many plant products are known mutagens and some are carcinogens.

Full Text