Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kurpad, Anura V.
- Pattern of Amino Acid Oxidation in Low BMI South Indian Pregnant Women
Abstract Views :306 |
PDF Views:1
Authors
Affiliations
1 Division of Nutrition, Department of Physiology, St. John’s Research Institute, Bangalore - 560 034, IN
2 Division of Epidemiology and Biostatistics, St. John’s Research Institute, Bangalore - 560 034, IN
1 Division of Nutrition, Department of Physiology, St. John’s Research Institute, Bangalore - 560 034, IN
2 Division of Epidemiology and Biostatistics, St. John’s Research Institute, Bangalore - 560 034, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 53, No 2 (2016), Pagination: 153-163Abstract
It is not known whether Indian pregnant women with low Body Mass Index (BMI) have adequate protein stores to provide sufficient amino acids for the growing fetus and how this interacts with the maternal body fat (energy) stores in early pregnancy. This study aimed to measure amino acid oxidation in pregnant women with low BMI and to evaluate the influence of maternal body fat on amino acid oxidation in early pregnancy. In two experimental studies of low BMI women, leucine oxidation rates significantly reduced from 1st to 3rd trimester (post absorptive state, p<0.002 and fed state, p<0.003, Wilcoxon sign rank test). In the post absorptive state in the 1st trimester, leucine oxidation negatively correlated with maternal fat percentage (r=-0.32, p=0.04). Hence, it would appear that the availability of body fat as an energy store in early pregnancy could reduce the utilization of amino acid as a substrate for the energy demands of the growing feto-placental unit.Keywords
Pregnancy, Low Body Mass Index, Protein Synthesis, Amino Acid Oxidation, 1st Trimester, Maternal Fat Percentage.References
- Bang, A.T., Reddy, H.M., Bang, R.A. and Deshmukh, M.D. Why do neonates die in rural Gadchiroli, India? (Part II): estimating population attributable risks and contribution of multiple morbidities for identifying a strategy to prevent deaths. J. Perinatol., 2005, 25, 35-43.
- Chhabra, P., Sharma, A.K., Grover, V.L. and Aggarwal, O.P. Prevalence of low birth weight and its determinants in an urban resettlement area of Delhi. Asia Pac. J. Public Health., 2004, 16, 95-98.
- Robert. B.E., Allen. L.H., Bhutta. Z.A., Caulfield. L.E., de Onis, M., Ezzati, M., Mathers, C. and Rivera, J. Maternal and child undernutrition: Global and regional exposures and health consequences. Lancet, 2008, 371, 243-260.
- Duggleby, S.L. and Jackson, A.A. Higher weight at birth is related to decrease maternal amino acid oxidation during pregnancy. Am. J. Clin. Nutr., 2002, 76, 852-857.
- Duggleby, S.L. and Jackson, A.A. Relationship of maternal protein turnover and lean body mass during pregnancy and birth length. Clin. Sci., 2001, 101, 65-72.
- Kurpad, A.V., Dwarkanath, P., Thomas, T., Mhaskar, A., Thomas, A., Mhaskar, R. and Jahoor, F. Comparison of leucine and dispensable amino acid kinetics between Indian women with low or normal body mass indexes during pregnancy. Am. J. Clin. Nutr., 2010, 92, 320-329.
- Dwarkanath, P., Hsu, J.W., Tang, G.J., Anand, P., Thomas, T., Thomas, A., Sheela, C.N., Kurpad, A.V. and Jahoor, F. Effect of energy and protein supplementation on amino acid kinetics and pregnancy outcomes in underweight Indian women. J. Nutr., 2016, (E pub ahead of print).
- Durnin, J.V.G.A. and Wormersely, J. Estimates of total body fat from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br. J. Nutr., 1974, 32, 77-79.
- Vaz, M., Bharathi, A.V., Muthayya, S. and Kurpad, A.V. Food frequency questionnairebased estimates of compliance to ATP III (National Cholesterol Education Programme). Recommended diets in the middleclass adult population of Bangalore city. J. Assoc. Physicians India., 2009, 57, 443-446.
- Dwarkanath, P., Soares, M.J., Thomas, T., Vaz, M., Swaminathan, S. and Kurpad, A.V. Food frequency questionnaire is a valid tool for the assessment of dietary habits of South Indian pregnant women. Asia Pac. J. Public Health., 2014, 26, 494-506. doi: 10.1177/ 1010539512459945.
- World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. Geneva, Switzerland: World Health Organization, 1995.
- Holmbäck, U., Forslund, A., Forslund, J., Hambraeus, L., Lennernäs, M., Lowden, A., Stridsberg, M. and Akerstedt, T. Metabolic responses to nocturnal eating in men are affected by sources of dietary energy. J. Nutr., 2002, 132, 1892-1899.
- Millward, D.J., Fereday, A., Gibson, N.R. and Pacy, P.J. Post-prandial protein metabolism. Baillieres Clin. Endocrinol. Metab., 1996, 10, 533-549.
- Thame, M.M., Hsu, J.W., Gibson, R., Baker, T.M., Tang, G.J., Badaloo, A.V., Fletcher, H.M., Jackson, A.A. and Jahoor, F. Adaptation of in vivo amino acid kinetics facilitates increased amino acid availability for fetal growth in adolescent and adult pregnancies alike. Br. J. Nutr., 2014,112, 1779-1786.
- Denne, S.C., Patel, D. and Kalhan, S.C. Leucine kinetics and fuel utilization during a brief fast in human pregnancy. Metab. 1991, 40, 1249-1256.
- Whittaker, P.G., Lee, C.H. and Taylor R. Whole body protein kinetics in women: effect of pregnancy and IDDM during anabolic stimulation. Am. J. Physiol. Endocrinol. Metab., 2000, 279, 978-988.
- Jolly, M., Bertie, J., Gray, R., Bannister, P., Venkatesan, S., Johnston, D. and Robinson, S. Increased leucine turnover in women during the third trimester of uncomplicated pregnancy. Metab., 2004, 53, 545-549.
- Kalhan, S.C., Tserng, K.Y., Gilûllan, C. and Dierker, L.J. Metabolism of urea and glucose in normal and diabetic pregnancy. Metab., 1982, 31, 824-833.
- Kalhan, S.C., Rossi, K.Q., Gruca, L.L., Super, D.M. and Savin, S.M. Relation between transamination of branched-chain amino acids and urea synthesis: evidence from human pregnancy. Am. J. Physiol., 1998, 275, 423-431.
- Villar, J., Cogswell, M., Kestler, E., Castillo, P., Menendez, R. and Repke, J.T. Effect of fat and fat-free mass deposition during pregnancy on birth weight. Am. J. Obstet. Gynecol., 1992, 167, 1344-1352.
- Owens, J.A., Owens, P.C. and Robinson, J.S. Experimental fetal growth retardation: metabolic and endocrine aspects. In: Gluckman, P.D., Johnston, B.M., Nathanielsz, P.W., eds. Advances in fetal physiology. New York: Perinatology Press, 1989, 263-286.
- Campbell, D., Hall, M., Barker, D., Cross, J., Shiell, A. and Godfrey, K. Diet in pregnancy and the offspring’s blood pressure 40 years later. Br. J. Obstet. Gynaecol., 1996, 103, 273-280.
- Hytten, F.E. and Leitch, I. The physiology of human pregnancy. 2nd ed. Oxford, United Kingdom: Blackwell Scientific Publications, 1971.
- Ounsted, M., Moar, V. and Scott, A. Neurological development of small-for-gestational age babies during the first year of life. Early Hum Dev. 1988, 16, 163-172.
- Issues in the Prevalence of Low Birth Weight in South India
Abstract Views :171 |
PDF Views:0
Authors
Affiliations
1 Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore - 560 034, IN
1 Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore - 560 034, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 44, No 1 (2007), Pagination: 96-106Abstract
Prevention of low birth weight (LBW; < 2500 g), which affects nearly 30 per cent of infants born in India, is a public health priority. LBW includes infants born prematurely (<37 weeks of gestation) or with intrauterine growth retardation (IUGR; <10th for gestational age). Since the majority of LBW infants in India and most developing countries are a result of IUG R, studies that explore the etiology of IUGR and interventions aimed at preventing foetal growth retardation are urgently needed.- Basal Metabolic Rate in Indian Male and Female Subjects of Differing Body Mass Index
Abstract Views :186 |
PDF Views:0
Authors
Affiliations
1 Division of Nutrition, Institute of Population Health and Clinical Research, St. John's National Academy of Health Sciences, Sarjapur Road, Bangalore - 560034, IN
2 Department of Food Service Management and Dietetics, Avinashilingam University, Coimbatore - 641 043, IN
1 Division of Nutrition, Institute of Population Health and Clinical Research, St. John's National Academy of Health Sciences, Sarjapur Road, Bangalore - 560034, IN
2 Department of Food Service Management and Dietetics, Avinashilingam University, Coimbatore - 641 043, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 42, No 9 (2005), Pagination: 392-404Abstract
The FAO/WHO/UNU Expert Consultation on Energy and Protein Requirements adopted the Basal Metabolic Rate (BMR) as the basis of expressing energy requirements. The BMR is the amount of energy used for a series of functions that are essential for life. It is measured under standard conditions that include being awake in the supine position after 10 to 12 hours of fasting and eight hours of physical rest, and being in a state of mental relaxation in an ambient environmental temperature that does not elicit heat-generating or heat-dissipating processes.- Effect of Increased Dietary Protein on the Plasma Methyl-Cycle Amino Acid Profile and Kinetics during Pregnancy
Abstract Views :280 |
PDF Views:1
Authors
Sarita Devi
1,
Tinku Thomas
2,
Pratibha Dwarkanath
1,
Annamma Thomas
3,
C. N. Sheela
3,
Arpita Mukhopadhyay
1,
Anura V. Kurpad
1
Affiliations
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Department of Obstetrics and Gynaecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Department of Obstetrics and Gynaecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 53, No 4 (2016), Pagination: 380-390Abstract
Low intakes of quality dietary protein could affect the methionine cycle during pregnancy, which is important for fetal growth and epigenetic regulations. Since low quality protein intake is prevalent in India, it is important to define biomarkers of the low protein intake, specifically of methyl cycle homeostasis. A secondary analysis of data was performed, from a randomized intervention trial with 500 ml milk/d on south Indian pregnant women, to examine the association of dietary protein intake with concentrations of specific amino acids (methionine, glycine and serine). The subjects also underwent isotopic infusions (n = 52) for the measurement of amino acid kinetics. Dietary intakes were measured each week by multiple 24 h recall until delivery. The plasma concentrations of amino acids (methionine, serine and glycine) were compared with kinetics of methionine i.e. transmethylation, remethylation and transulfuration (TM, RM, TS) and serine to glycine conversion rates, as measured by stable isotope labeled amino acid infusion. Dietary protein intake in the 3rd trimester correlated positively with intakes of milk and milk based food products (ρ=0.52, p<0.001) and methionine (ρ=0.97, p<0.001) and with gestational weight gain (GWG, ρ=0.32, p=0.044). While the methionine concentration did not correlate with methyl cycle flux parameters (TM, RM and TS), the plasma concentrations of conditionally essential serine and glycine were positively correlated with their respective flux rate and with RM, TM and TS rates. Further, glycine concentrations specifically correlated positively with serine to glycine conversion rates (ρ=0.32, p=0.027). Dietary protein and methionine supply are important for the conservation of methionine during pregnancy. This had an effect on GWG, but not on birth weight, though this may have been due to the relatively small sample size. The plasma concentration of glycine was correlated with the serine-glycine conversion, which affords methyl groups for the body and supplies these when dietary protein/methionine is in poor supply. This indicates that itcan act as a biomarker of the serine-glycine conversion flux rate, which increases in the presence of a poor protein supply. In general, the plasma concentrations of these conditionally essential amino acids may be biomarkers of the methyl cycle during pregnancy, but this needs to be tested in a larger sample.Keywords
Amino Acid Kinetics, Maternal Protein Intake, Glycine, Serine, Methionine Cycle, Pregnancy.References
- FAO/WHO/UNU. Protein and amino acid requirements in human nutrition: report of a joint WHO/FAO/UNU expert consultation. World Health Organ Tech Rep Ser #935. Geneva, Switzerland: FAO/WHO/UNU, 2007:276.
- A Report of the Expert Group of the Indian Council of Medical Research. Nutrient Requirements and Recommended Dietary Allowances for Indians. NIN. ICMR; 2010.
- Kalhan, S.C. Protein metabolism in pregnancy. Am. J. Clin. Nutr., 2000, 71, 1249-1255.
- Peterson, C.L. and Laniel, M.A. Histones and histone modifications. Curr. Biol., 2004, 14, 546–551.
- Felig, P., Kim, Y.J., Lynch, V. and Hendler, R. Amino acid metabolism during starvation in human pregnancy. J. Clin. Invest., 1972, 51, 1195–1202.
- Metzger, B.E., Unger, R.H. and Freinkel, N. Carbohydrate metabolism in pregnancy. XIV.
- Relationships between circulating glucagon, insulin, glucose and amino acids in response to a “mixed meal” in late pregnancy. Metabol., 1977, 26, 151–156.
- Schoengold, D.M., DeFiore, R.H. and Parlett, R.C. Free amino acids in plasma throughout pregnancy. Am. J. Obstet. Gynecol., 1978, 131, 490–499.
- Kalhan, S.C., Tserng, K., Gilfillan, C. and Dierker, L.J. Metabolism of urea and glucose in normal and diabetic pregnancy. Metabol., 1982, 31, 824–833.
- Lamers, Y., Williamson, J., Gilbert, L.R., Stacpoole, P.W. and Gregory, J.F. 3rd. Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2] glycine and [(2)H3] leucine. J. Nutr., 2007, 137, 2647–2652.
- Lamers, Y., Williamson, J., Theriaque, D.W., Shuster, J.J., Gilbert, L.R., Keeling, C., et al. Production of 1-carbon units from glycine is extensive in healthy men and women. J. Nutr., 2009, 139, 666–671.
- Meier, P., Teng, C., Battaglia, F.C. and Meschia, G. The rate of amino acid nitrogen and total nitrogen accumulation in the fetal lamb. Proc. Soc. Exp. Biol. Med., 1981, 167, 463–468.
- Duggan, C., Srinivasan, K., Thomas, T., Samuel, T., Rajendran, R., Muthayya, S., et al. Vitamin B12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J. Nutr., 2014, 144, 758-764.
- Kanade, A.N., Rao, S., Kelkar, R.S. and Gupte, S. Maternal nutrition and birth size among urban affluent and rural women in India. J. Am. Coll. Nutr., 2008, 27, 137-145.
- Godfrey, K., Robinson, S., Barker, D.J., Osmond, C. and Cox, V. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ, 1996, 312, 410414.
- Olsen, S.F., Halldorsson, T.I., Willett, W.C., Knudsen, V.K., Gillman, M.W., Mikkelsen, T.B. and Olsen, J. NUTRIX Consortium. Milk consumption during pregnancy is associated with increased infant size at birth: prospective cohort study. Am. J. Clin. Nutr., 2007, 86, 1104-1110.
- Mannion, C.A., Gray-Donald, K. and Koski, K.G. Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. CMAJ., 2006, 174, 1273-1237.
- Dasarathy, J., Gruca, L.L., Bennett, C., Parimi, P.S., Duenas, C., Marczewski, S., et al. Methionine metabolism in human pregnancy. Am. J. Clin. Nutr., 2010, 91, 357-365.
- Thame, M., Fletcher, H., Baker, T. and Jahoor, F. Comparing the in vivo glycine fluxes of adolescent girls and adult women during early and late pregnancy. Br. J. Nutr., 2010, 104, 498-502.
- Maternal Methyl-Cycle Amino Acid Profile and Kinetics:Relation with Placental Growth
Abstract Views :248 |
PDF Views:3
Authors
Sarita Devi
1,
Julian Crasta
2,
Tinku Thomas
3,
Pratibha Dwarkanath
1,
Annamma Thomas
4,
C. N. Sheela
4,
Anura V. Kurpad
1,
Arpita Mukhopadhyay
1
Affiliations
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Department of Pathology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
4 Department of Obstetrics and Gynecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
1 Division of Nutrition, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
2 Department of Pathology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
3 Division of Epidemiology and Biostatistics Unit, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
4 Department of Obstetrics and Gynecology, St. John’s Medical College, St. John’s National Academy of Health Sciences, Bangalore-560 034, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 54, No 2 (2017), Pagination: 118-126Abstract
Maternal intake of quality protein regulates placental development and function thereby affecting fetal growth. Considering the prevalence of inadequate intakes of quality protein in Indian pregnant women, understanding the interplay between maternal supply of protein, its metabolism and fetoplacental growth becomes important. A secondary analysis of data from an open labelled-randomized intervention trial with 500 ml milk/day on south Indian pregnant women with marginally low vitamin B12 status, was performed to assess the relations between placental parameters and maternal trimester 3 methyl-cycle amino acid status as well as kinetics. This analysis was performed for 42 pregnancies from the trial where placentae had been collected and placental parameters had been measured. For these pregnancies, data on trimester 3 methionine, serine and glycine kinetics as well as plasma free amino acid concentrations were available. Protein intake and plasma citrulline concentrations were positively correlated at trimester 3 (ρ = 0.34, P = 0.027). Placental weight correlated positively with methyl-cycle specific amino acid concentrations [methionine (ρ = 0.32, P = 0.0388), serine (ρ = 0.49, P = 0.0009)], methionine kinetics [total methionine flux rates (ρ = 0.42, P = 0.006), RM (ρ = 0.45, P = 0.003), TS (ρ = 0.32, P = 0.046), TM (ρ = 0.45, P = 0.004)] and with birth weight (ρ = 0.57, P < 0.001). Findings from the current study indicate that maternal amino acid availability and more importantly, maternal methionine kinetics, positively influenced placental growth, likely mediated by key amino acids such as citrulline, which is known to regulate placental blood flow and function. As an appropriately functioning placenta is indispensable for fetal growth, these findings will form the basis for detailed mechanistic explorations into the placental regulation of maternal supply of amino acid to the fetus for designing effective intervention strategies towards optimizing fetomaternal health during and after pregnancy.Keywords
Vitamin B12, Pregnancy, Glycine, Methionine, Serine, Methionine Kinetic, Amino Acids.References
- Godfrey, K., Robinson, S., Barker, D.J., Osmond, C. and Cox, V. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ. 1996, 312, 410-414.
- Moore, V.M., Davies, M.J., Willson, K.J., Worsley, A. and Robinson, J.S. Dietary composition of pregnant women is related to size of the baby at birth. J. Nutr., 2004, 134, 1820-1826.
- Herrera, E. Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur. J. Clin. Nutr., [Internet]. 2000, 54, 47-51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10805038
- Hadden, D.R. and McLaughlin, C. Normal and abnormal maternal metabolism during pregnancy. Semin. Fetal Neonat. Med., [Internet]. 2009, 14, 66-71. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1744165X08001157
- Duggleby, S.L. and Jackson, A.A. Relationship of maternal protein turnover and lean body mass during pregnancy and birth length. Clin, Sci., (Lond). 2001, 101, 65-72.
- Kalhan, S.C. One-Carbon Metabolism, Fetal Growth and Long-Term Consequences. 2013. p. 127–38. Available from: http://www.karger.com?doi=10.1159/000348459
- Dasarathy, J., Gruca, L.L., Bennett, C., Parimi, P.S., Duenas, C., Marczewski, S. and Fierro, J.L. Methionine metabolism in human pregnancy 1- 3. Am. J. Clin. Nutr., 2010.
- Kalhan, S.C., Uppal, S.O., Moorman, J.L., Bennett, C., Gruca, L.L., Parimi. P.S., Dasarathy, S., Serre, D. and Hanson, R.W. Metabolic and genomic response to dietary isocaloric protein restriction in the rat. J. Biol. Chem., 2011, 286, 5266-5277.
- Kalhan, S.C. One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health. Mol. Cell Endocrinol., [Internet]. 2016, 435, 48-60. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0303720716302052
- Belkacemi, L., Nelson, D.M., Desai, M. and Ross, M.G. Maternal under nutrition influences placental-fetal development. Biolreprod., 2010, 83, 325-331.
- Campbell, D.M., Hall, M.H., Barker, D.J., Cross, J., Shiella, W. and Godfrey, K.M. Diet in pregnancy and the offspring’s blood pressure 40 years later. Br. J. Obstet. Gynaecol., 1996, 103, 273-280.
- Duggan, C., Srinivasan, K., Thomas, T., Samuel, T., Rajendran, R., Muthayya, S., Finkelstein, J.L., Lukose, A., Fawzi, W., Allen, L.H., et al. Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J. Nutr., 2014, 144, 758-764.
- Badaloo, A., Hsu, J.W., Taylor-Bryan, C., Green, C., Reid, M., Forrester, T. and Jahoor, F. Dietary cysteine is used more efficiently by children with severe acute malnutrition with edema compared with those without edema. Am. J. Clin. Nutr., [Internet]. 2012, 95, 84-90. Available from: http://www.ajcn.org/cgi/doi/10.3945/ajcn.111.024323
- Dwarkanath, P., Hsu, J.W., Tang, G.J., Anand, P., Thomas, T., Thomas, A., Sheela, C., Kurpad, A.V. and Jahoor, F. Energy and protein supplementation does not affect protein and amino acid kinetics or pregnancy outcomes in underweight Indian women. J. Nutr., [Internet]. 2016, 146, 218-226. Available from: http://jn.nutrition.org/cgi/doi/10.3945/jn.115.218776
- Windelberg, A., Årseth, O., Kvalheim, G. and Ueland, P.M. Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin. Chem., 2005, 51, 2103-2109.
- Devi, S., Thomas, T., Dwarkanath, P., Thomas, A., Sheela, C.N., Mukhopadhyay, A. and Kurpad, A.V. Effect of increased dietary protein on the plasma methyl-cycle amino acid profile and kinetics during pregnancy. Ind. J. Nutr. Diet., 2016, 53, 380-390.
- Jourdan, M., Nair, K.S., Carter, R.E., Schimke, J., Ford, G.C., Marc, J., Aussel, C. and Cynober, L. Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet – A pilot study. Clin. Nutr., [Internet]. 2015, 34, 449-456. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0261561414001277
- Dasarathy, J., Gruca, L.L., Bennett, C., Parimi, P.S., Duenas, C., Marczewski, S., Fierro, J.L. and Kalhan, S.C. Methionine metabolism in human pregnancy. Am. J. Clin. Nutr., [Internet]. 2010, 91, 357-365. Available from: http://www.ajcn.org/cgi/doi/10.3945/ajcn.2009.28457
- Kwon, H. Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids. Biol. Reprod., [Internet]. 2004, 71, 901-908. Available from: http://www.biolreprod.org/cgi/doi/10.1095/biolreprod.104.029645
- Bourdon, A., Parnet, P., Nowak, C., Tran, N.T., Winer, N. and Darmaun, D.L. Citrulline supplementation enhances fetal growth and protein synthesis in rats with intrauterine growth restriction. J. Nutr., [Internet]. 2016, 146, 532-541. Available from: http://jn.nutrition.org/cgi/doi/10.3945/jn.115.221267
- Moinard, C. and Cynober, L. Citrulline: A new player in the control of nitrogen homeostasis. J. Nutr., [Internet]. 2007, 137, 1621-1625. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/17513438
- Tran, N.T., Amarger, V., Bourdon, A., Misbert, E., Grit, I., Winer, N. and Darmaun, D. Maternal citrulline supplementation enhances placental function and fetal growth in a rat model of IUGR: involvement of insulin-like growth factor 2 and angiogenic factors. J. Matern Fetal Neonatal Med., [Internet]. 2016, 1-6. Available from: http:// www.ncbi.nlm.nih.gov/pubmed/27572235
- Davis, S.R. Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. AJP Endocrinol. Metab., [Internet]. 2003, 286, 272-279. Available from: http://ajpendo.physiology.org/cgi/ doi/10.1152/ajpendo.00351.2003
- Rees, W.D., Hay, S.M., Buchan, V., Antipatis, C. and Palmer, R.M. The effects of maternal protein restriction on the growth of the rat fetus and its amino acid supply. Br. J. Nutr., [Internet]. 1999, 81, 243-250. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 10434851
- Thame, M., Fletcher, H., Baker, T. and Jahoor, F. Comparing the in vivo glycine fluxes of adolescent girls and adult women during early and late pregnancy. Br. J. Nutr., [Internet]. 2010, 104, 498-502. Available from: http://www.journals.cambridge.org/ abstract_S0007114510000784
- Hayward, C.E., Lean, S., Sibley, C.P., Jones, R.L., Wareing, M., Greenwood, S.L. and Dilworth, M.R. Placental adaptation: what can we learn from birthweight:placental weight ratio? Front. Physiol., [Internet]. 2016, 7, 28. Available from: http://journal.frontiersin.org/ Article/10.3389/fphys.2016.00028/abstract.
- Are HDL Enzyme Activities Better Indices of Cardio-Metabolic Risk than HDL-C Levels?
Abstract Views :280 |
PDF Views:1
Authors
Affiliations
1 Division of Nutrition, St. John’s Research Institute, St. John’s Medical College, Bangalore, IN
2 Department of Biochemistry, St. John’s Medical College, Bangalore, IN
1 Division of Nutrition, St. John’s Research Institute, St. John’s Medical College, Bangalore, IN
2 Department of Biochemistry, St. John’s Medical College, Bangalore, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 54, No 3 (2017), Pagination: 253-264Abstract
Metabolic Syndrome (MS) is a combination of physiological factors that result in increased risk for developing Cardio Vascular Diseases (CVD). One factor that has traditionally been accepted as being athero-protective is High Density Lipoprotein (HDL). However increasing reports suggest that plasma levels of HDL-C do not reflect its functionality, which is mainly attributed to its cargo of antioxidant enzymes. The study was aimed at assessing key HDL-associated enzymes as potentially better biomarkers in evaluating risk of MS and thus CVD than merely HDL-C levels in an urban South Indian population. The study consisted of patients with MS (n=41) and age matched controls (n=65). Anthropometry, routine blood biochemistry and HDL associated enzyme activities were measured. Of the HDL enzymes, paraoxonase-1 (PON-1) activity was seen to be lower whereas Lecithin Cholesterol Acyl Transferase (LCAT) was higher in subjects with MS (p<0.01). Multiple logistic regression showed that low PON-1 activity and high LCAT activity had an increased AOR for MS (RR=3.8, 95% CI-1.1, 13.3, p=0.035, and RR=17.5, 95% CI-3.9, 77.5, p<0.001 respectively), independent of HDL-C levels. This study demonstrates the prevalence of impaired function of HDL enzymes in patients with MS, which might promote inflammation, oxidative stress and atherogenesis. It also suggests that estimating the activities of key HDL enzymes such as PON-1 and LCAT could improve the accuracy of MS and CVD risk prediction than mere measurement of HDL-C levels.Keywords
CVD, HDL-C, Inflammation, LCAT, Metabolic Syndrome, PON-1.References
- Wasir, J.S. and Misra, A. The metabolic syndrome in Asian Indians: Impact of nutritional and socio-economic transition in India. Metab. Syndr. Relat. Disord., 2004, 2, 14–23.
- Joshi, S.R., Anjana, R.M., Deepa, M., Pradeepa, R., Bhansali, A. Dhandania, V.K. et al., Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. PLoS One 2014, doi:10.1371/journal.pone.0096808.
- Farbstein, D. and Levy, A.P. HDL dysfunction in diabetes: causes and possible treatments. Expert Rev. Cardiovasc. Ther., 2012, 10, 353–361.
- Haas, M.J. and Mooradian, A.D. Inflammation, high-density lipoprotein and cardiovascular dysfunction. Curr. Opin. Infect. Dis., 2011, 24, 265–272.
- Dodani, S., Kaur, R., Reddy, S., Reed, G.L., Navab, M. and George, V. Can dysfunctional HDL explain high coronary artery disease risk in South Asians? Int. J. Cardiol., 2008, 129, 125–132.
- Dodani, S. Excess coronary artery disease risk in South Asian immigrants: Can dysfunctional high-density lipoprotein explain increased risk? Vasc. Health Risk Manag., 2008, 4, 953–961.
- Sini, S. and Jayakumari, N. Functionally defective high density lipoprotein is pro-oxidant: a deviation from normal atheroprotective character. Int. J. Fd. Sci. Nutr., 2013, 2, 92–101.
- Navab. M., Hama, S.Y., Hough, G.P., Subbanagounder, G., Reddy, S.T. and Fogelman, A.M. A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids. J. Lipid Res., 2001, 42, 1308–1317.
- Burlina, A., Michielin, E. and Galzigna, L. Characteristics and behavior of arylesterase in human serum and liver. Eur. J. Clin. Invest., 1977, 7, 17–20.
- Krueger, A.J., Yang, J.J., Roy, T.A., Robbins, D.J. and Mackerer, C.R. An automated myeloperoxidase assay. Clini. Chem., 1990, 36, 158.
- Ramachandran, A., Ma, R.C. and Snehalatha, C. Diabetes in Asia. Lancet., 2010, 30, 408-418. doi: 10.1016/S0140-6736(09)60937-5.
- Srikanthan, K., Feyh, A., Visweshwar, H., Shapiro, J.I. and Sodhi, K. Systematic review of metabolic syndrome biomarkers: A panel for early detection, management and risk stratification in the West Virginian population. Int. J. Med. Sci., 2016, 13, 25-38. doi: 10.7150/ijms.13800.
- Paneni, F., Cosentino, F., Marrara, F., Palano, F., Capretti, G., Gregori, M. The clinical relevance of dysfunctional HDL in patients with coronary artery disease: A 3-year follow-up study. Int. J. Cardiol., 2012, 158–160.
- Baron, A.A. and Baron, S.B. High levels of HDL cholesterol do not predict protection from cardiovascular disease in women. Prev. Cardiol., 2007, 10, 125–127.
- Mackness, M.I., Arrol, S., Abbott, C. and Durrington, P.N. Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis, 1993, 104, 129–135.
- Mackness, M.I., Arrol, S. and Durrington, P.N. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett., 1991, 286, 152–154.
- Heinecke, J.W. and Lusis, A.J. Paraoxonase-gene polymorphisms associated with coronary heart disease: support for the oxidative damage hypothesis? Am. J. Hum. Genet., 1998, 62, 20–24.
- Mastorikou, M., Mackness, M. and Mackness, B. Defective metabolism of oxidized phospholipid by HDL from people with type 2 diabetes. Diabetes, 2006, 55, 3099-3103.
- Baynes, J.W. Role of oxidative stress in development of complications in diabetes. Diabetes, 1991, 40, 405–412.
- Flekac, M., Skrha, J., Zidkova, K., Lacinová, Z. and Hilgertova, J. Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus. Physiol. Res., 2008, 57, 717–726.
- Mogarekar, M.R., Dhabe, M.G. and Gujrathi, C.C. A study of paraoxonase1 (PON1) activities, HDL cholesterol and its association with vascular complication in type 2 diabetes mellitus. Int. J. Diab. Dev. Countries, 2016, 1–6.
- Amine, K., Atouk, A., Moussamih, S., Saile, R., Mikou, A. and Kettani, A. Paraoxonase-1 (PON1) activity in patients with coronary artery diseases and in diabetic patients. Ann. Biol. Clin., 2011, 69, 671–677.
- Dullaart, R.P., Perton, F., van der Klauw, M.M., Hillege, H.L., Sluiter, W.J. et al., High plasma lecithin: cholesterol acyltransferase activity does not predict low incidence of cardiovascular events: possible attenuation of cardio protection associated with high HDL cholesterol. Atherosclerosis, 2010, 208, 537–542.
- Holleboom, A.G., Kuivenhoven, J.A., Vergeer, M., Hovingh, G.K., van Miert, J.N., Wareham, N.J. et al. Plasma levels of lecithin: cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: A prospective case-control analysis nested in the EPIC-Norfolk population study. J. Lipid Res., 2010, 51, 416–421.
- McPherson, P.A., Young, I.S. and McEneny, J. A dual role for lecithin: cholesterol acyltransferase (EC 2.3. 1.43) in lipoprotein oxidation. Free Radic. Biol. Med., 2007, 43, 1484–1493.
- Gruppen, E.G., Connelly, M.A., Otvos, J.D., Bakker, S.J. and Dullaart, R.P. A novel protein glycan biomarker and LCAT activity in metabolic syndrome. Eur. J. Clin. Invest., 2015, 45, 850–859. doi: 10.1111/eci.12481.
- Ng, D.S. Lecithin cholesterol acyltransferase deficiency protects from diet-induced insulin resistance and obesity—novel insights from mouse models. Vitam. Horm., 2013, 91, 259-270. doi: 10.1016/B978-0-12-407766-9.
- Esser, N., Legrand-Poels, S., Piette, J., Scheen, A.J. and Paquot, N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res. Clin. Pract., 2014, 105, 141–150.
- Schindhelm, R.K., van der Zwan, L.P., Teerlink, T. and Scheffer, P.G. Myeloperoxidase: A useful biomarker for cardiovascular disease risk stratification? Clin. Chem., 2009, 55, 1462–1470.
- Morgantini, C., Natali, A., Boldrini, B., Imaizumi, S., Navab, M., Fogelman, A.M., et al., Anti-inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes. Diabetes, 2011, 60, 2617–2623.
- Effect of a Single Session of Acute Aerobic Exercise on the Activities of High Density Lipoprotein Enzymes
Abstract Views :241 |
PDF Views:1
Authors
Affiliations
1 Division of Nutrition, St John’s Research Institute, Bangalore, IN
2 Department of Biochemistry, St. John’s Medical College and Hospital, Bangalore, IN
1 Division of Nutrition, St John’s Research Institute, Bangalore, IN
2 Department of Biochemistry, St. John’s Medical College and Hospital, Bangalore, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 55, No 1 (2018), Pagination: 18-28Abstract
High Density Lipoprotein (HDL) is considered to be an anti-atherogenic molecule and its beneficial function is driven by a number of enzymes such as LCAT (Lecithin Cholesterol Acyl Transferase), PON1 (Paraoxonase 1), PAF-AH (Platelet-Activating Factor Acetyl Hydrolase) and CETP (Cholesteryl Ester Transfer Protein). Low HDL-C level is the most prevalent dyslipidemia seen in India and exercise is one reliable way to improve its levels. While acute exercise is known to increase HDL-C levels, not much is known about its effects on HDL functions. This study was aimed at assessing the effect of a single bout of acute aerobic exercise on key HDL functions. Ten healthy adult male volunteers (20-35 years) were made to exercise at 65-80% VO2 max to expend 200 Kcal using a modified Bruce protocol. Plasma samples were collected at different time points (before exercise, 15 min, 1 hour, 2 hours, 4 hours, 24 hours, 48 hours post-exercise) for analysis of HDL anti-inflammatory function and its related enzyme activities. Friedman ANOVA followed by post-hoc Wilcoxon matched pair test, showed that PON1 activity increased immediately but reached significance 48 hours post-exercise (Z=-2.666, p=0.008). CETP and LCAT activities were decreased significantly at the 4th hour post-exercise and continued to be low even up to 48 hours (Z=-2.666, p=0.008), whereas HDL-C levels, MPO activity and HDL-II did not vary significantly at different time points. Enhanced activity of the antioxidant enzyme PON1, in combination with decreased activities of pro-atherogenic enzymes CETP and LCAT suggest that even a single bout of acute exercise could be effective in eliciting athero-protective changes in HDL function independent of HDL-C levels.Keywords
Acute Exercise, Antioxidant Enzymes, CETP, HDL-C, PON1.References
- Guptha, S., Gupta, R., Deedwania, P., Bhansali, A., Maheshwari, A., Gupta A., et al. Cholesterol lipoproteins and prevalence of dyslipidemias in urban Asian Indians: A cross sectional study. Ind. Heart. J., 2014, 66, 280-8.
- Briel, M., Ferreira-Gonzalez, I., You, J.J., Karanicolas, P.J., Akl, E.A., et al. Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis. BMJ., 2009, 338, b92.
- Dodani, S., Grice, D.G. and Joshi, S. Is HDL function as important as HDL quantity in the coronary artery disease risk assessment? J. Clin. Lipidol., 2009, 3, 70-77.
- Navab, M., Reddy, S.T., Van Lenten, B.J. and Fogelman, A.M. HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms. Nat. Rev. Cardiol., 2011, 8, 222-232.
- Eren, E., Yilmaz, N. and Aydin, O. High density lipoprotein and its dysfunction. Open. Biochem. J., 2012, 6, 78-93.
- Despres, J.P. and Lamarche, B. Low-intensity endurance exercise training, plasma lipoproteins and the risk of coronary heart disease. J. Intern. Med., 1994, 236, 7-22.
- Durstine, J.L. and Haskell, W.L. Effects of exercise training on plasma lipids and lipoproteins. In: Exercise and Sport Sciences Reviews, edited by J.O. Holloszy. Baltimore, MD: Williams & Wilkins, 1994, 477-521.
- Thompson, P.D., Cullinane, E.M., Sady, S.P., Flynn, M.M., Bernier, D.N., Kantor, M.A., et al. Modest changes in high-density lipoprotein concentration and metabolism with prolonged exercise training. Circulation., 1988, 78, 25-34.
- Wood, P.D., Stefanick, M.L., Dreon, D.M., Frey-Hewitt, B., Garay, S.C., Williams, P.T., et al. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N. Engl. J. Med., 1988, 319, 1173-1179.
- Gomez-Cabrera, M.C., Domenech, E. and Vina, J. Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training. Free. Radic. Biol. Med., 2008, 44, 126-131.
- Tseng, M.L., Ho, C.C., Chen, S.C., Huang, Y.C., Lai, C.H. and Liaw, Y.P. A simple method for increasing levels of high-density lipoprotein cholesterol: A pilot study of combination aerobic and resistance-exercise training. Int. J. Sport. Nutr. Exerc. Metab., 2013, 23, 271-81.
- Sharma, M., Rao, M., Jacob, S. and Jacob, C.K. Validation of 24-hour dietary recall: A study in hemodialysis patients. J. Ren. Nutr., 1998, 8, 199-202.
- Bharathi, A.V., Sandhya, N. and Vaz, M. The development and characteristics of a physical activity questionnaire for epi-demiological studies in urban middle class Indians. J. Med. Res., 2000, 111, 95-102.
- Bruce, R.A., Kusumi, F. and Hosmer, D. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am. Heart. J., 1973, 85, 546-562.
- Navab, M., Hama, S.Y., Hough, G.P., Subbanagounder, G., Reddy, S.T. and Fogelman, A.M. A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids. J. Lipid. Res., 2001, 42, 1308-1317.
- Burlina, A., Michielin, E. and Galzigna, L. Characteristics and behavior of arylesterase in human serum and liver. Eur. J. Clin. Invest., 1977, 7, 17-20.
- Krueger, A.J., Yang, J.J., Roy, T.A., Robbins, D.J. and Mackerer, C.R. An automated myeloperoxidase assay. Clin. Chem., 1990, 36, 158.
- Fisher-Wellman, K. and Bloomer, R.J. Acute exercise and oxidative stress: A 30 year history. Dyn Med., 2009, 8, 1.
- Mackness, M.I., Arrol, S., Abbott, C.A. and Durrington, P.N. Protection of low density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis, 1993, 104, 129-135.
- Aviram, M., Rosenblat, M., Bisgaier, C.L., Newton, R.S., Primo-Parmo, S.L. and La Du, B.N. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J. Clin. Invest., 1998, 101, 1581-1590.
- Taylor, J.K., Esco, M.R., Qian, L., Dugan, K. and Jones, K. A single session of aerobic exercise influences paraoxonase 1 activity and concentration. Retos., 2015, 27, 222-225.
- Otocka-Kmiecik, A., Lewandowski, M., Szkudlarek, U., Nowak, D. and Orlowska-Majdak, M. Aerobic training modulates the effects of exercise-induced oxidative stress on PON1 activity: A preliminary study. Sc. World Jr., 2014, doi:10.1155/2014/230271.
- Toma´s, M., Elosua, R., Senti, M., Molina, L., Vila, J., Anglada, R., et al. Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity. J. Lipid. Res., 2002, 43, 713e20.
- Nalcakan, G.R., Varol, S.R., Turgay, F., Nalcakan, M., Ozkol, M.Z. and Karamizrak, S.O. Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women. J. Sport and Health Sci., 2015, http://dx.doi.org/10.1016/j.jshs.2015.01.010.
- Iborra, R.T., Ribeiro, I.C., Neves, M.Q., Charf, A.M., Lottenberg, S.A., Negrao, C.E., et al. Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus. Scand. J. Med. Sci. Sports., 2008, 18, 742-750.
- Zahabi, G., Barari, A.R., Farzanegi, P. and Ahmadi, M. Effect of concurrent training on the serum paraoxonase-1(PON-1) activity and lipid profile in obese men. Intl. Res. J. Appl. Basic. Sci., 2014, 8, 1434-1437.
- Tsopanakis, C., Kotsarellis, D. and Tsopanakis, A. Plasma lecithin: cholesterol acyltransferase activity in elite athletes from selected sports. Eur. J. Appl. Physiol., 1988, 58, 262-265.
- Dullaart, R.P., Perton, F., van der Klauw, M.M., Hillege, H.L. and Sluiter, W.J., PREVEND Study Group. High plasma lecithin: cholesterol acyltransferase activity does not predict low incidence of cardiovascular events: possible attenuation of cardioprotection associated with high HDL cholesterol. Atherosclerosis, 2010, 208, 537-542.
- Holleboom, A.G., Kuivenhoven, J.A., Vergeer, M., Hovingh, G.K., van Miert, J.N., Wareham, N.J., et al. Plasma levels of lecithin: cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study. J. Lipid. Res., 2010, 51, 416-21.
- McPherson, P.A., Young, I.S. and McEneny, J.A. Dual role for lecithin: cholesterol acyltransferase (EC 2.3. 1.43) in lipoprotein oxidation. Free. Radic. Biol. Med., 2007, 43, 1484-1493.
- Dullaart, R.P., Perton, F., Sluiter, W.J., de Vries, R. and van Tol, A. Plasma lecithin:cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness. J. Clin. Endocrinol. Metab., 2008, 93, 4860-4866.
- Gruppen, E.G., Connelly, M.A., Otvos, J.D., Bakker, S.J. and Dullaart, R.P. A novel protein glycan biomarker and LCAT activity in metabolic syndrome. Eur. J. Clin. Invest., 2015, 45, 850-859. doi: 10.1111/eci.12481.
- Ng, D.S. Lecithin cholesterol acyltransferase deficiency protects from diet-induced insulin resistance and obesity-novel insights from mouse models. Vitam. Horm., 2013, 91, 259-70. doi: 10.1016/B978-0-12-407766-9.
- Takanami, Y., Iwane, H., Kawai, Y., Katsumura, T. and Shimomitsu, T. Influence of strenuous endurance exercise on cholesteryl transfer protein and HDL metabolism in serum (Abstract). Med. Sci. Sports. Exerc., 1996, 28, S29.
- Grandjean, P.W., Crouse, S.F. and Rohack, J.J. Influence of cholesterol status on blood lipid and lipoprotein enzyme responses to aerobic exercise. J. Appl. Physiol., 2000, 89, 472-480.
- Seip, R.L., Moulin, P., Cocke, T., Tall, A., Kohrt, W.M. and Mankowitz, K. Exercise training decreases plasma cholesteryl ester transfer protein. Arterioscler. Thromb., 1993, 13, 9.
- Foger, B., Wohlfarter, T., Ritsch, A., Lechleitner, M., Miller, C.H. and Dienstl, A. Kinetics of lipids, apolipoproteins, and cholesteryl ester transfer protein in plasma after a bicycle marathon. Metab., 1994, 43, 633-639.
- Pownall, H.J., Rosales, C., Gillard, B.K. and Ferrari, M. Native and Reconstituted Plasma lipoproteins in nanomedicine: physicochemical determinants of nanoparticle structure, stability and metabolism. Methodist. Debakey. Cardiovasc. J., 2016, 12, 146-150.
- Effect of 3-Month Lysine Supplementation on Growth and Muscle Function Parameters in Pre-pubertal Indian Girls
Abstract Views :317 |
PDF Views:1
Authors
Affiliations
1 Department of Physiology, St. John’s Medical College, Bangalore, IN
2 Division of Nutrition, St. John’s Research Institute, Bangalore, IN
1 Department of Physiology, St. John’s Medical College, Bangalore, IN
2 Division of Nutrition, St. John’s Research Institute, Bangalore, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 55, No 4 (2018), Pagination: 423-431Abstract
Lysine is the limiting amino acid in the predominantly cereal and legume based typical Indian diet and its supplementation has been shown to positively affect muscle strength in short term adult and animal models; but similar studies are lacking in children. This study looked at the effect of a 3-month lysine and iron intervention on muscle strength and growth parameters in prepubertal Indian girls. The study was a randomized controlled trial conducted in 40 normal Indian girls in the 9-10 yrs age group. The control group received only iron (6.25mg) supplementation, while the intervention group received both iron and lysine supplementation that increased the lysine intake to 50mg/kg/day. Muscle strength was estimated in both upper limbs with a hand dynamometer and muscle endurance was estimated in the non-dominant hand. Height and weight were recorded to assess growth. A significant difference was seen in the increase in the non-dominant hand grip strength between the groups (intervention: 1.4 vs control: 0.2 kg, p=0.042) at the end of the study. There was a trend of increased height gain (about 25%) and weight gain (about 50%) in the intervention group compared to control group. Lysine supplementation for 3 months increased non-dominant forearm muscle strength in Indian children.Keywords
Lysine Supplementation, Handgrip, Muscle Strength, Growth.References
- Unni, U.S., Raj, T., Sambashivaiah, S., Kuriyan, R., Uthappa, S., Vaz, M. and Kurpad, A.V. The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men. Clin. Nutr., 2012, 31, 903-910. doi:10.1016/j.clnu.2012.03.008.
- Kurpad, A.V., Regan, M.M., Raj, T., El-Khoury, A., Kuriyan, R., Vaz, M. and Young, V.R.
- Lysine requirements of healthy adult Indian subjects receiving long-term feeding, measured with a 24-h indicator amino acid oxidation and balance technique. Am. J. Clin. Nutr., 2002, 76, 404-412. doi:10.1093/ajcn/76.2.404.
- Flakoll, P., Sharp, R., Baier, S., Levenhagen, D., Carr, C. and Nissen, S. Effect of betahydroxybeta-methylbutyrate, arginine and lysine supplementation on strength, functionality, body composition and protein metabolism in elderly women. Nutr., 2004, 20, 445-451. doi:10.1016/j.nut.2004.01.009.
- Rutherfurd, S.M., Bains, K. and Moughan, P.J. Available lysine and digestible amino acid contents of proteinaceous foods of India. Br. J. Nutr., 2012, 108, S59-68. doi:10.1017/ S0007114512002280.
- Engle-Stone, R., Aaron, G.J., Huang, J., Wirth, J.P., Namaste, S.M., Williams, A.M. and Suchdev, P.S. Predictors of anemia in preschool children: Biomarkers reflecting inflammation and nutritional determinants of anemia (BRINDA) project. Am. J. Clin. Nutr., 2017, 106, 402-415. doi:10.3945/ajcn.116.142323.
- Hussain, T., Abbas, S., Khan, M.A. and Scrimshaw, N.S. Lysine fortification of wheat flour improves selected indices of the nutritional status of predominantly cereal-eating families in Pakistan. Fd. Nutr. Bull., 2004, 25, 114-122. doi:10.1177/156482650402500202.
- Unni, U.S., Ramakrishnan, G., Raj, T., Kishore, R.P., Thomas, T., Vaz, M. and Kurpad, A.V. Muscle mass and functional correlates of insulin sensitivity in lean young Indian men. Eur. J. Clin. Nutr., 2009, 63, 1206-1212. doi:10.1038/ejcn.2009.32.
- Leong, D.P., Teo, K.K., Rangarajan, S., Lopez-Jaramillo, P., Avezum, A., Jr. and Orlandini, A. Prospective Urban Rural Epidemiology Study, prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet, 2015, 386, 266-273. doi:10.1016/S0140-6736(14)62000-6.
- Volaklis, K.A., Halle, M. and Meisinger, C. Muscular strength as a strong predictor of mortality: A narrative review. Eur. J. Intern. Med., 2015, 26, 303-310. doi:10.1016/ j.ejim.2015.04.013
- Zibellini, J., Seimon, R.V., Lee, C.M., Gibson, A.A., Hsu, M.S. and Sainsbury, A. Effect of diet-induced weight loss on muscle strength in adults with overweight or obesity - a systematic review and meta-analysis of clinical trials. Obes. Rev., 2016, 17, 647-663. doi:10.1111/obr.12422.
- Recommendations to prevent and control iron deficiency in the United States. Centers for Disease Control and Prevention. MMWR Recomm. Rep., 1998, 47 (RR-3), 1-29.
- Tous, N., Lizardo, R., Vila, B., Gispert, M., Font, I.F.M. and Esteve-Garcia, E. Effect of reducing dietary protein and lysine on growth performance, carcass characteristics, intramuscular fat and fatty acid profile of finishing barrows. J. Anim. Sci., 2014, 92, 129-140. doi:10.2527/jas.2012-6222.
- Ishida, A., Kyoya, T., Nakashima, K. and Katsumata, M. Muscle protein metabolism during compensatory growth with changing dietary lysine levels from deficient to sufficient in growing rats. J. Nutr. Sci. Vitaminol., (Tokyo), 2011, 57, 401-408. doi:10.3177/jnsv.57.401.
- Sato, T., Ito, Y. and Nagasawa, T. Regulation of skeletal muscle protein degradation and synthesis by oral administration of lysine in rats. J. Nutr. Sci. Vitaminol., (Tokyo), 2013, 59, 412-419. doi:10.3177/jnsv.59.412..
- Chen, J.D. Benefits of physical activity on nutrition and health status: studies in China.
- Asia Pac. J. Clin. Nutr., 1995, 4, 29-33.
- Pillai, R.R., Elango, R., Muthayya, S., Ball, R.O., Kurpad, A.V. and Pencharz, P.B. Lysine requirement of healthy, school-aged Indian children determined by the indicator amino acid oxidation technique. J. Nutr., 2010, 140, 54-59. doi:10.3945/jn.109.113357.
- Uauy, R., Kurpad, A., Tano-Debrah, K., Otoo, G.E., Aaron, G.A., Toride, Y. and Ghosh, S. Role of protein and amino acids in infant and young child nutrition: protein and amino acid needs and relationship with child growth. J. Nutr. Sci. Vitaminol (Tokyo)., 2015, 61, S192-194. doi:10.3177/jnsv.61.S192.
- Khadilkar, V.V. and Khadilkar, A.V. Revised Indian Academy of Pediatrics 2015 growth charts for height, weight and body mass index for 5-18-year-old Indian children. Ind. J. Endocrinol. Metab., 2015, 19, 470-476. doi:10.4103/2230-8210.159028.
- Kim, J., Lee, K.S., Kwon, D.H., Bong, J.J., Jeong, J.Y., Nam, Y.S. and Baik, M. Severe dietary lysine restriction affects growth and body composition and hepatic gene expression for nitrogen metabolism in growing rats. J. Anim. Physiol. Anim. Nutr (Berl)., 2014, 98, 149-157. doi:10.1111/jpn.12061.
- Harbo, T., Brincks, J. and Andersen, H. Maximal isokinetic and isometric muscle strength of major muscle groups related to age, body mass, height, and sex in 178 healthy subjects. Eur. J. Appl. Physiol., 2012, 112, 267-275. doi:10.1007/s00421-011-1975-3.
- Chang, Y.O. and Chao, N. Influence of various levels of lysine intake on weight gain and body composition in rats. J. Agri. Fd. Chem., 1969, 17, 48-50. doi:10.1021/jf60161a002.
- Protein Intakes in Rural India – Implications of Protein Quality
Abstract Views :343 |
PDF Views:0
Authors
Affiliations
1 St. John's Acadamy of Health Sciences, A recongnized Research Centre of University of Mysore, Division of Nutrition, St. John's Research Institute, Bengaluru, IN
1 St. John's Acadamy of Health Sciences, A recongnized Research Centre of University of Mysore, Division of Nutrition, St. John's Research Institute, Bengaluru, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 58, No 1 (2021), Pagination: 151-158Abstract
A prevalence of 18% Low Birth Weight (LBW), 38% stunting in <5y children, and 18% sarcopenia in adults have been recently reported in India. These could partly be due to a poor-quality protein intake, which could support positive birth outcomes, linear growth in children and maintenance of the adult skeletal muscle mass with appropriate exercise. Quality protein is a highly digestible protein with adequate quantity of Indispensable Amino Acids (IAA). The measurement of risk of deficient quality protein intake requires knowledge of IAA requirements and their digestibility from different food proteins. The present analyses, using dietary intake data of different age groups from the latest National Nutrition Monitoring Bureau rural survey, showed that the protein quality of rural Indian diets was suboptimal and had considerable impact on the risk of quality protein deficiency, which varied from 14 to 80% among different age groups. Modest additions of animal source foods (such as milk and egg) could alleviate the risk of quality protein deficiency in the population. Dietary protein quality should be considered while evaluating dietary interventions and framing the policy of supplementary nutrition programs for vulnerable populations.Keywords
Dietary Protein, Amino Acids, Protein Quality, Stunting, Under Nutrition, Low Birth Weight, Animal Source Foods.References
- International Institute of Population Science (IIPS). National Family Health Survey India (NFHS-4) 2015-2016 Report, 2016. Available from: http://rchiips.org/nfhs/factsheet_nfhs-4.shtml.
- Tyrovolas, S., Koyanagi, A., Olaya, B., Ayuso Mateos, J.L., Miret, M., Chatterji, S., Tobiasz Adamczyk, B., Koskinen, S., Leonardi, M. and Haro, J.M. Factors associated with skeletal muscle mass, sarcopenia and sarcopenic obesity in older adults: A multi continent study. J. cachexia, sarcopenia and muscle, 2016, 7, 312-321.
- Mukhopadhyay, A., Dwarkanath, P., Bhanji, S., Devi, S., Thomas, A., Kurpad, A.V. and Thomas, T. Maternal intake of milk and milk proteins is positively associated with birth weight: A prospective observational cohort study. Clin. Nutr. ESPEN., 2018, 1, 103-109.
- Millward, D.J. Nutrition, infection and stunting: the roles of deficiencies of individual nutrients and foods and of inflammation, as determinants of reduced linear growth of children. Nutr. Res. Rev., 2017, 30, 50.
- Burd, N.A., McKenna, C.F., Salvador, A.F., Paulussen, K.J. and Moore, D.R. Dietary protein quantity, quality and exercise are key to healthy living: A muscle-centric perspective across the lifespan. Fronti. Nutr., 2019, 6, 83.
- Food and Agricultural Organisation. Dietary protein quality evaluation in human nutrition: Report of an FAO Expert Consultation. FAO Food and Nutrition Paper No. 92. Rome: FAO; 2013.
- World Health Organization and United Nations University. Protein and amino acid requirements in human nutrition (Vol. 935). 2007.
- Nutritional intake in India (2011–12), National Service Scheme (68th round) (2014).National Sample Survey Office, Government of India. 2014. Report No.: 560. Available from: http://www.indiaenvironmentportal.org.in/files/file/nutritional%20intake%20in%20India%202011-12.pdf
- National Nutrition Monitoring Bureau (2012) Diet and Nutritional Status of Rural Population, Prevalence of Hypertension and Diabetes among Adults and Infant and Young Child Feeding Practices. National Institute of Nutrition, Indian Council of Medical Research. Hyderabad (India) http://nnmbindia.org/1_NNMB_Third_Repeat_Rural_Survey_Technicl_Report_26.pdf
- Shivakumar, N., Kashyap, S., Kishore, S., Thomas, T., Varkey, A., Devi, S., Preston, T., Jahoor, F., Sheshshayee, M.S. and Kurpad, A.V. Protein-quality evaluation of complementary foods in Indian children. The Am. J. Clin. Nutr., 2019, 109, 1319-1327.
- Longvah, T., Anantan, I., Bhaskarachary, K., Venkaiah, K. and Longvah, T. Indian food composition tables. Hyderabad: National Institute of Nutrition, Indian Council of Medical Research; 2017.
- Bandyopadhyay, S., Shivakumar, N. and Kurpad, A.V. Protein intakes of pregnant women and children in India-protein quality implications. Mater. Child Nutr., 2020, 16, 12952.
- Kashyap, S., Shivakumar, N., Sejian, V., Deutz, N.E.P., Preston, T., Sheshshayee, S., Devi, S. and Kurpad, A.V. Goat milk protein digestibility in relation to intestinal function. The Am. J. Clin. Nutr., 2020.
- Swaminathan, S., Ghosh, S., Varghese, J.S., Sachdev, H.S., Kurpad, A.V. and Thomas, T. Dietary iron intake and anemia are weakly associated, limiting effective iron fortification strategies in India. The J. Nutr.. 2019, 149, 831-839.
- Liberato, S.C., Singh, G. and Mulholland, K. Effects of protein energy supplementation during pregnancy on fetal growth: A review of the literature focusing on contextual factors. Fd. Nutr. Res., 2013, 57, 20499.
- Iannotti, L.L., Lutter, C.K., Stewart, C.P., Riofrío, C.A., Malo, C., Reinhart, G., Palacios, A., Karp, C., Chapnick, M., Cox, K. and Waters, W.F. Eggs in early complementary feeding and child growth: a randomized controlled trial. Pediat., 2017, 140,1-11.
- Allen, L.H. and Dror, D.K. Effects of animal source foods, with emphasis on milk, in the diet of children in low-income countries. In Milk and milk products in human nutrition 2011 (Vol. 67, pp. 113-130). Karger Publishers.
- Kashyap, S., Varkey, A., Shivakumar, N., Devi, S., Reddy, B. H. R., Thomas, T., Preston, T., Sreeman, S. and Kurpad, A.V. True ileal digestibility of legumes determined by dual-isotope tracer method in Indian adults. The Am. J. Clin. Nutr., 2019, 110, 873-882.
- Crawford, P.B., Obarzanek, E., Morrison, J. and Sabry, Z.I. Comparative advantage of 3-day food records over 24-hour recall and 5-day food frequency validated by observation of 9-and 10-year-old girls. J. Am. Diet. Assoc., 1994, 94, 626-630.
- In Vitro Protein Digestibility of Selected Plant and Animal Foods by Multi-Enzyme Assay
Abstract Views :198 |
PDF Views:0
Authors
Affiliations
1 Division of Nutrition, St. John’s Research Institute, St. John’s Academy of Health Sciences, A Recognized Research Centre of University of Mysore, Bengaluru, IN
1 Division of Nutrition, St. John’s Research Institute, St. John’s Academy of Health Sciences, A Recognized Research Centre of University of Mysore, Bengaluru, IN