The Indian Journal of Nutrition and Dietetics

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Association between Muscle Mass, Body Fat Mass, and Abdominal Circumstances with Insulin Resistance among Young Adult Population with Prediabetes Risk


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1 Faculty of Medicine, Diponegoro University, Semarang, Central Java - 50269, Indonesia
     

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Prediabetesis is associated with an increase in plasma insulin concentration due to a decrease in insulin sensitivity in insulin target organs. Central obesity is a risk factor for prediabetes. To determine the relationship between muscle mass, body fat mass, and abdominal circumference with insulin resistance. The study was involving 50 young adult subjects aged 15-35 years, 50 subjects who met the inclusion and exclusion criteria. Muscle mass and body fat mass were measured using Bioelectrical Impedance Analysis (BIA). Abdominal circumference was measured using a tapemeter. Hours of sleep were measured using a questionnaire, while physical activity was measured based on the IPAQ-short form. Insulin resistances were measured using HOMA-IR score. Data were analyzed using spearman correlation. The correlation between abdominal circumference using two kinds of measurement and HOMA IR was found in all subjects (r = 0.691 and r 0.659; p = 0.000). After being analyzed separately by gender, it was found that there are positive correlation between body fat mass and HOMA-IR (male r = 0.672 p 0.001 female r = 0.582 p 0.001). There were a negative correlation between skeletal muscle mass and HOMA-IR (male r= -0.653 p 0.002, female r= -0.424, p 0.019), but there was no relationship between physical activity and sleep hours with insulin resistance. There is a relationship between skeletal muscle mass, fat mass, and abdominal circumference on insulin resistance regardless of gender. Further study is needed to determine the cutoff point of HOMA-IR as the predictor of insulin resistance.


Keywords

Insulin Resistance, Body Fat Mass, Skeletal Muscle Mass, Abdominal Circumference, HOMA-IR, Prediabetes, Body Composition, BIA.
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  • Association between Muscle Mass, Body Fat Mass, and Abdominal Circumstances with Insulin Resistance among Young Adult Population with Prediabetes Risk

Abstract Views: 226  |  PDF Views: 1

Authors

Anindya Putri Adhisti
Faculty of Medicine, Diponegoro University, Semarang, Central Java - 50269, Indonesia
Siti Fatimah-Muis
Faculty of Medicine, Diponegoro University, Semarang, Central Java - 50269, Indonesia
Amalia Sukmadianti
Faculty of Medicine, Diponegoro University, Semarang, Central Java - 50269, Indonesia
Darmono S.S.
Faculty of Medicine, Diponegoro University, Semarang, Central Java - 50269, Indonesia
Febe Christianto
Faculty of Medicine, Diponegoro University, Semarang, Central Java - 50269, Indonesia

Abstract


Prediabetesis is associated with an increase in plasma insulin concentration due to a decrease in insulin sensitivity in insulin target organs. Central obesity is a risk factor for prediabetes. To determine the relationship between muscle mass, body fat mass, and abdominal circumference with insulin resistance. The study was involving 50 young adult subjects aged 15-35 years, 50 subjects who met the inclusion and exclusion criteria. Muscle mass and body fat mass were measured using Bioelectrical Impedance Analysis (BIA). Abdominal circumference was measured using a tapemeter. Hours of sleep were measured using a questionnaire, while physical activity was measured based on the IPAQ-short form. Insulin resistances were measured using HOMA-IR score. Data were analyzed using spearman correlation. The correlation between abdominal circumference using two kinds of measurement and HOMA IR was found in all subjects (r = 0.691 and r 0.659; p = 0.000). After being analyzed separately by gender, it was found that there are positive correlation between body fat mass and HOMA-IR (male r = 0.672 p 0.001 female r = 0.582 p 0.001). There were a negative correlation between skeletal muscle mass and HOMA-IR (male r= -0.653 p 0.002, female r= -0.424, p 0.019), but there was no relationship between physical activity and sleep hours with insulin resistance. There is a relationship between skeletal muscle mass, fat mass, and abdominal circumference on insulin resistance regardless of gender. Further study is needed to determine the cutoff point of HOMA-IR as the predictor of insulin resistance.


Keywords


Insulin Resistance, Body Fat Mass, Skeletal Muscle Mass, Abdominal Circumference, HOMA-IR, Prediabetes, Body Composition, BIA.

References