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Sharma, Vikas
- Jatamansi:A Source against Lung and Colon Cancer Cells
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Authors
Affiliations
1 Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, JAMMU (J&K), IN
1 Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus Chatha, JAMMU (J&K), IN
Source
International Journal of Medical Sciences, Vol 9, No 1 (2016), Pagination: 19-21Abstract
In vitro assay for cytotoxic activity of Nardostachys jatamansi has been carried out against eight human cancer cell lines from six different tissues via 95 per cent methanolic and aqueous extract at the concentration of 100 μg/ml using Sulphorhodamine blue (SRB) assay. Results revealed that methanolic extract from the stem leaves of N. jatamansi showed highest in vitro cytotoxic effect against four human cancer cell lines (A-549, COLO-205, SW-620, NCI-H322) from lung and colon origin. Based on in vitro data, it is suggested that further in vivo studies as well as identification of effective components from methanolic extract and their exact mechanism of action could be useful in designing new anticancer therapeutic agents.Keywords
Nardostachys jatamansi, In vitro Cytotoxic, Cancer Cells, SRB Assay.
References
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- Ali, S., Ansari, K.A., Jafry, M.A., Kabir, H. and Devakar, G. (2000). Nardostachys jatamansi protects against liver damage induced by thioacetamide in rats. J. Ethnopharmacol., 71: 359-363
- Bael, G.S., Kim, M.S., Park, K.C., Koo, B.S., Jo, I. J., Choi, S.B., Lee, D.S., Kim, Y.C., Kim, T.H., Seo, S.W., Shin, Y.K., Song, H.J. and Park, S.J. (2012). Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis. World J. Gastroenterol 18: 3223-3234.
- Dhingra, D. and Goyal, P.K. (2008). Inhibition of MAO and GABA: Probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice. Indian J. Exp. Biol., 46: 212-218.
- Kandil, O., Radwan, N. M., Hassan, A. B., Amer, A. A. M., El-banna, H. A. and Amer, W. M. M. (1994). Extracts and fractions of Thymus capitatus exhibit antimicrobial activities. J. Ethnopharmacol. 45: 97-111.
- Lyle, N., Bhattacharyya, D., Sur, T. K., Munshi, S., Paul, S., Chatterjee, S. and Gomes, A. (2009). Stress modulating antioxidant effect of Nardostachys jatamansi. Indian J. Biochem. Biophys., 46: 93-98.
- Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., VaigroWolff, A., Gray-Goodrich, M., Campbell, H., Mayo, J. and Boyd, M. (1991). Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst., 83: 57-66.
- Pandita, R.M., Bhagat, M. and Saxena A.K. (2012). Evaluation of in vitro cytotoxicity of Nardostachys jatamansi ischolar_main extracts and fractions against neuroblastoma human cancer cell lines. J. Pharm. Res., 5: 2720-2722.
- Salim, S., Ahmed, M., Zafar, K.S., Ahmad A. S. and Islam, F. (2003). Protective effect of jatamansi in rat cerebal ischemia. Pharmacol. Biochem. Behav., 74: 481-486.
- Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMohan, J., Vistica, D., Warren, J.T., Bokesch, H., Kenney, S. and Boyd, M.R. (1990). New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst., 82: 1107-1112.
- Acacia senegal Possesses in vitro Cytotoxicity Against Human Cancer Cells
Abstract Views :342 |
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Authors
Affiliations
1 Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology (J.), Chatha, Jammu (J&K), IN
1 Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology (J.), Chatha, Jammu (J&K), IN
Source
International Journal of Medical Sciences, Vol 9, No 2 (2016), Pagination: 84-87Abstract
In vitro assay for cytotoxic activity of Acacia senegal has been carried out against four human cancer cell lines from four different tissues via aqueous extract at the concentration of 10, 30 and 100 μg/ml using Sulphorhodamine blue (SRB) assay. Results revealed that fruit and seed part of the plant showed remarkable in vitro cytotoxic potential against three human cancer cells of cervical (SiHa), neuroblastoma (IMR-32) and lung (A-549) origin at the concentration of 30 and 100 μg/ml. Based on in vitro data, it is suggested that further in vivo studies as well as identification of effective components could be useful in designing new anti-cancer therapeutic agents from this particular plant.Keywords
Acacia senegal, Human Cancer Cells, Neuroblastoma.References
- Adel, R.A.A., Abdulaziz, A.A., Abdulhakim, A.A., Ali, M.G., Mohammad, H.D., Othman, A.A. and El-Azab, S. (2009). Acacia senegal Gum exudate offers protection against cyclophosphamide induced urinary bladder cytotoxicity. Oxid. Med. Cell Longev., 2 : 207-213.
- Ali, A.A., Ali, K.E., Fadlalla, A. and Khalid, K.E. (2008). The effects of GA oral treatment on the metabolic profile of chronic renal failure patients under regular haemodialysis in Central Sudan. Nat. Prod. Res., 22 : 12-21.
- Ali, B.H. and Al Moundhri, M.S. (2006). Agents Ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: A review of some recent research. Food Chem. Toxicol., 44: 1173-1183.
- Glover, D.A., Ushida, K., Phillips, A.O. and Riley, S.G. (2009). Acacia senegal: An evaluation of potential health benefits in human subjects. Food Hydrocoll., 23: 2410-2415.
- Hinson, J.A., Reid, A.B., McCullogh, S.S. and James, L.P. (2004). Acetaminophen induced hepatotoxicity: Role of metabolic activation, reactive oxygen/ nitrogen species and mitochondrial permeability transition. Drug Metab. Rev., 36: 805-822.
- Majekodunmi, O.F., Ruchi, G.M., Ramla, A.M., Gouri, B.V., Hussain, A.B. and SuadKhamis, S.A. (2006). Antioxidant capacity of some edible and wound healing plants in Oman. Food Chem., 2 : 465-470.
- Matsumoto, N., Riley, S., Fraser, D., Al-Assaf, S., Ishimura, E., Wolever, T., Philips, G.O. and Philips, A.O.
- (2006). Butyrate modulates TGF-beta1 generation and function: potential renal benefit for Acacia (SEN) Supergum (GA). Kidney Int., 69: 257-265.
- Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., VaigroWolff, A., Gray-Goodrich, M., Campbell, H., Mayo, J. and Boyd, M. (1991). Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst., 83 : 57-66.
- Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMohan, J., Vistica, D., Warren, J.T., Bokesch, H., Kenney, S. and Boyd, M.R. (1990). New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst., 82 : 1107-1112.
- Trommer, H. and Neubert, R.H. (2005).The examination of polysaccharides as potential antioxidative compounds for topical administration using a lipid model system. Internat. J. Pharm., 298 : 153-163.
- Wapnir, R.A., Sherry, B., Codipilly, C.N., Goodwin, L.O. and Vancurova, I. (2008).Modulation of rat intestinal nuclear factor NF- KappaB by gum Arabic.Rat small intestine by gum. Arabic. Dig. Dis. Sci., 53 : 80-87.
- Anti-Cancer Activity of Arka (Calotropis procera) on HCT-15 Cancer Cell Line
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Authors
Affiliations
1 School of Biotechnology, University of Jammu, Jammu (J&K), IN
2 Division of Biochemistry and Plant Physiology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, FOA, Main Campus, Chatha, Jammu (J&K), IN
1 School of Biotechnology, University of Jammu, Jammu (J&K), IN
2 Division of Biochemistry and Plant Physiology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, FOA, Main Campus, Chatha, Jammu (J&K), IN
Source
International Journal of Medical Sciences, Vol 2, No 2 (2010), Pagination: 152-154Abstract
In vitro assay for cytotoxic activity of the stem-leaves of Calotropis procera was carried out against human cancer cell lines at the concentration of 10, 30 and 100μg/ml. Results revealed that the extracts of the plant possessed in vitro anticancer potential against HCT-15 (colon) cancer cell line at different concentrations. Further, the fractionation of the extracts was carried out and the fractions were tested on the same human cancer cell line. It was found that all the fractions inhibited the growth of HCT-15 at 100μg/ml except water-soluble fractions, but the significant growth inhibition was shown by the chloroform-soluble fractions of the ethanolic extract and 50% ethanolic extract.Keywords
Calotropis procera, In vitro Cytotoxic, Human Cancer Cell Lines.- In vitro Cytotoxic Potential of Calotropis gigantea R.Br. Against Human Cancer Cell Lines
Abstract Views :269 |
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Authors
Affiliations
1 School of Biotechnology, University of Jammu, Jammu (J&K), IN
2 Division of Biochemistry and Plant Physiology, Sher-e-Kashmir University of Agricultural Science and Technology (J), Jammu (J&K), IN
1 School of Biotechnology, University of Jammu, Jammu (J&K), IN
2 Division of Biochemistry and Plant Physiology, Sher-e-Kashmir University of Agricultural Science and Technology (J), Jammu (J&K), IN