International Journal of Medical Sciences

K. Satya Narayana ¹, Sravanthi Koora ², Ivvala Anand Shaker ³, S. Saleem Basha ³, K. Suresh Babu ³

Affiliations
1 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur (T.N.), IN
2 Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar (A.P.), IN
3 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), IN

Abstract

Both diabetes and thyroid disorders involve dysfunction of the endocrine system. Almost one third of people with type 1 diabetes have been found to have thyroid disease. Since both diseases are parallel and influence one another. Any alteration in thyroid hormones may have further complication such as CAD. Low T₃ syndrome is well established in development of CAD. In the present study we assessed the circulating thyroid hormones and glycemic status among Diabetic population. T₃ levels are low in both Type I and II diabetes, and are directly correlated with poor glycemic control. Among the diabetic population women are worse affected than men. In conclusion, many diabetics showed a low T₃ levels, suggesting that there may be impairment in the extrathyroidal conversion of T₄ to T₃ (5' deiodinization) and in turn enhanced by a poor glycemic control. The study reveals that frequent checkup for thyroid hormones are compulsory to prevent further complications.

Keywords

Glycemic Status, Diabetes Mellitus, Thyroid Dysfunction, 5' Deiodinization, Low T₃ Syndrome, CAD.

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S. Saleem Basha ¹, I. Anand Shaker ¹, Senthil Kumar ¹, K. Satya Narayana ¹, K. Suresh Babu ¹

Affiliations
1 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), IN

Abstract

The background evidence of the association between H. pylori and peptic ucler is reviewed, together with methods of diagnosing H. pylori infection. Serological testing is considered to be simple, cheap and effective. At least one authority considers serological tests for H. pylori to be the "gold standard" against which all other should be measured. Helicobacter pylori (HP) are Gram negative spiral bacterial which occur in the muhan stomach. The bacteria were cultured in vitro for the first time in 1983, it is suspected that the bacteria may cause chronic gastritis of type B and may also be a contributory cause of chronic ulceration and cancer of the stomach. The bacteria are accompanied by characteristic inflammatory changes in the gastic mucosa. The significance for gastritis, chronic ulceration, non-ulcer dyspepsia and carcionoma of the stomach is discussed. Helicobacter pylori occurs in great proportion of the population of the world and the frequency increases with age. The route of infection is unknown but faecal-oral infection is probable. Our knowledge about the cause of peptic ulcer disease, of the aetiology of gastric cancer, and perhaps of some forms of dypepsia is in a state of revolution. The discovery of the infective organism Helicobacter pylori and its involvement in these diaseses has begun to change our views on how to approach diagnosis and treatment. Correlation between the presence of HP and occurrence of symptom is poor in the individual patient, the bacteria can be demonstrated histologically, cytological, by culture by the urease test, by the urease expiration test or serologically. The bacteria are sensitive for a series of antibiotics and bismuth but no effective treatment it known as the recurrence is high.

Keywords

Helicobacter pylori, Ulcer.

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