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Prashanth, S. J.
- In Vitro Anticancer and Hepatoprotective Activities of Artocarpus gomezianus
Authors
1 Dr. P. Sadananda Maiya Centre for Food Science and Research, Jayanagara, Bengaluru (Karnataka), IN
2 Department of Studies and Research in Chemistry, Tumkur University, Tumkur (Karnataka), IN
Source
International Journal of Medical Sciences, Vol 7, No 1-2 (2014), Pagination: 18-23Abstract
The study aimed at assessing the potency of hydroalcoholic extracts of various parts of Artocarpus gomezianus against cancer using in vitro cell lines. MCF-7, HepG2, HeLa, PC3, A549 and Vero cell lines were employed for the assessment. The ability of extracts to exert toxic insult on cancer cells has been the basis of anticancer activity. Among the extracts from different parts of Artocarpus, AGR was found to be toxic with average CTC50 values of 110 μg/ml. With regard to A549 cell lines, AGR was found to be highly toxic with value of CTC50 273 μg/ml, respectively. The results clearly demonstrate that the extracts of selected plants exert potential anticancer activity. In vitro hepatoprotective activity of the plant extracts was studied by employing primary rat hepatocytes. Our results indicate that the drug Silymarin was found to exhibit 96% protection against Paracetamol induced toxicity in Hep G2 cells at the tested concentration of 250 mg/ml. Among the different extracts of Artocarpus gomezianus, AGF, AGR and AGA were found to have comparatively lower protective power than Silymarin. In paracetamol induced toxicity of primary rat hepatocytes, the drug Silymarin was found to exhibit 85.28% protection against Paracetamol induced toxicity in Primary rat hepatocytes at the tested concentration of 250 mg/ml. It was found that extracts of Artocarpus gomezianus, considerably lesser activity when compared to the standard silymarin. The extract of Artocarpus gomezianus may be considered for further studies as they appear to be very promising antiproliferative agents.Keywords
Artocarpus gomezianus, Plant Extracts, Anticancer, Hepatoprotective Activity.
- Extraction, Pharmacognosy Studies, Phytochemical Analysis and in vitro Antioxidant Studies of Garcinia xanthochymus
Authors
1 Dr. P. Sadananda Maiya Centre for Food Science and Research, Jayanagara, Bengaluru (Karnataka), IN
2 Department of Studies and Research in Chemistry and Centre for Nanoscience Research, Tumkur University, Tumkur (Karnataka), IN
Source
International Journal of Medical Sciences, Vol 5, No 1-2 (2012), Pagination: 37-46Abstract
The present investigation aims to understand the Garcinia xanthochymus with regard to its extractive values, pharmacognosy studies, phytochemical analysis and in vitro antioxidant studies. Pharmacognosy parameters such as moisture content, extractive values, fluorescence parameters, and ash values were determined. Preliminary phytochemical analysis indicates that the extracts contain alkaloids, flavonoids, phenolics and tannins, phytosterols and triterpenoids. Ferric ion reducing property was found to be maximum for the fruit extract where as the nitric oxide scavenging activity of all the three extracts was not very significant compared to rutin. ABTS radical scavenging activity of fruits extract was considerably high compared to the other extracts. However, the total antioxidant activity was found to be significantly high for the extract from aerial parts than the extracts from fruits and ischolar_main. It is evident from the studies that various parts of Garcinia xanthochymus contained significantly higher amounts of health beneficial phytochemicals. It is also clear that the extract of aerial parts, fruits and ischolar_mains possessed potentially beneficial antioxidant activities. In view of its use in ancient medicine coupled with the recent understandings of the Garcinia xanthochymus the plant may be considered for further exploration as very potent nutraceutical.